Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0458 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.6764 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.6764 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.6764 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.6764 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.6764 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.6764 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0458 | 0 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0458 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0458 | 0 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0458 | 0 | 0.5 |
Onchocerca volvulus | 0.0458 | 0 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0458 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0458 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0458 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0458 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.6764 | 1 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0458 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0458 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0458 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0458 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0458 | 0 | 0.5 |
Onchocerca volvulus | 0.0458 | 0 | 0.5 | |
Trypanosoma brucei | oxidoreductase-like protein | 0.0458 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0458 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.6764 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0458 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0458 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0458 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0458 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0458 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.28 uM | Concentration required to reduce by 50% the amount of lipid peroxide formed in rat liver microsomes | ChEMBL. | 9046347 |
ID50 (functional) | = 24.6 mg kg-1 | Peroral dose required to reduce by 50% the score of excitatory behavior induced by intrathecal injection of ferrous chloride in mice | ChEMBL. | 9046347 |
ID50 (functional) | = 24.6 mg kg-1 | Peroral dose required to reduce by 50% the score of excitatory behavior induced by intrathecal injection of ferrous chloride in mice | ChEMBL. | 9046347 |
Increase (functional) | = 56.4 % | Percentage increase of locomotor activity in mice | ChEMBL. | 9046347 |
Increase (functional) | = 56.4 % | Percentage increase of locomotor activity in mice | ChEMBL. | 9046347 |
Locomotor activity (functional) | = 1540 | Locomotor activity was measured in mice after 1 hour administration of methamphetamine | ChEMBL. | 9046347 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.