Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0871 | 1 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0807 | 0.8693 | 1 |
Onchocerca volvulus | 0.0807 | 0.8693 | 0.5 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0807 | 0.8693 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0807 | 0.8693 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0871 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0871 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0807 | 0.8693 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0807 | 0.8693 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0807 | 0.8693 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0807 | 0.8693 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0384 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0871 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0871 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0807 | 0.8693 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Percent inhibition of human telomerase was determined by stretch PCR assay with use of 100 microM of the ligand | ChEMBL. | 11229776 |
Inhibition (binding) | = 0 % | Percent inhibition of human telomerase was determined by stretch PCR assay with use of 100 microM of the ligand | ChEMBL. | 11229776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.