Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0155 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0155 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0155 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0155 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0155 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0155 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0155 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0155 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0155 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0155 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0155 | 1 | 0.5 |
Onchocerca volvulus | 0.0155 | 1 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0155 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0155 | 1 | 1 |
Onchocerca volvulus | 0.0155 | 1 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0155 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.5 nM | In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells | ChEMBL. | 12477359 |
IC50 (binding) | = 16.5 nM | In vitro binding affinity for recombinant human glucagon receptor (hGGR) in BHK cells | ChEMBL. | 12477359 |
Metabolism (ADMET) | = 130 pM min-1 mg-1 | Turnover in rat liver microsomes | ChEMBL. | 12477359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.