Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.047 | 0.0014 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.2783 | 0.3658 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0461 | 0 | 0.5 |
Onchocerca volvulus | 0.047 | 0.0014 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.6808 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0461 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0461 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.047 | 0.0014 | 0.0039 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.6808 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.047 | 0.0014 | 0.0039 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.047 | 0.0014 | 0.0039 |
Brugia malayi | Carboxylesterase family protein | 0.2783 | 0.3658 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.047 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.2783 | 0.3658 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.047 | 0.0014 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Brugia malayi | Carboxylesterase family protein | 0.047 | 0.0014 | 0.0039 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2783 | 0.3658 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.047 | 0.0014 | 0.0039 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.047 | 0.0014 | 0.0039 |
Brugia malayi | Carboxylesterase family protein | 0.047 | 0.0014 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Echinococcus multilocularis | acetylcholinesterase | 0.2783 | 0.3658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2783 | 0.3658 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2783 | 0.3658 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.047 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Leishmania major | pteridine reductase 1 | 0.0461 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.047 | 0.0014 | 0.0039 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.6808 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.6808 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.6808 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2783 | 0.3658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Schistosoma mansoni | gliotactin | 0.047 | 0.0014 | 0.0039 |
Trypanosoma brucei | pteridine reductase 1 | 0.0461 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.047 | 0.0014 | 0.0039 |
Schistosoma mansoni | acetylcholinesterase | 0.047 | 0.0014 | 0.0039 |
Echinococcus granulosus | acetylcholinesterase | 0.2783 | 0.3658 | 1 |
Onchocerca volvulus | 0.047 | 0.0014 | 1 | |
Brugia malayi | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.047 | 0.0014 | 0.0039 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0461 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.0014 | 0.0039 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.047 | 0.0014 | 0.0039 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.6808 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0461 | 0 | 0.5 |
Onchocerca volvulus | 0.047 | 0.0014 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.2783 | 0.3658 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.047 | 0.0014 | 0.0039 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0461 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0461 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2783 | 0.3658 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.047 | 0.0014 | 0.0039 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.047 | 0.0014 | 0.0014 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2783 | 0.3658 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0461 | 0 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.047 | 0.0014 | 0.0039 |
Brugia malayi | Carboxylesterase family protein | 0.047 | 0.0014 | 0.0039 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0461 | 0 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.047 | 0.0014 | 0.0039 |
Leishmania major | oxidoreductase-like protein | 0.0461 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.047 | 0.0014 | 0.0039 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.047 | 0.0014 | 0.0014 |
Onchocerca volvulus | 0.047 | 0.0014 | 1 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.6808 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2783 | 0.3658 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.047 | 0.0014 | 0.0039 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.6808 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 3.6 uM | Inhibition of ADP-induced activation of rat platelets using aggregometry | ChEMBL. | 12477353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.