Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | nM | Tested for its binding affinity for alpha-2 adrenergic receptor site by displacement of [3H]-clonidine at 10e-6 M concentration;NA means no activity | ChEMBL. | 2879919 |
Ki (binding) | 0 nM | Tested for its binding affinity for alpha-2 adrenergic receptor site by displacement of [3H]-clonidine at 10e-6 M concentration;NA means no activity | ChEMBL. | 2879919 |
Ki (binding) | = 1.6 nM | Compound was tested for its binding affinity for alpha-1 adrenergic receptor site by displacement of [3H]-clonidine at 10e-6 M concentration | ChEMBL. | 2879919 |
Ki (binding) | = 1.6 nM | Compound was tested for its binding affinity for alpha-1 adrenergic receptor site by displacement of [3H]-clonidine at 10e-6 M concentration | ChEMBL. | 2879919 |
Reduction (functional) | = 12 % | Percent reduction in blood pressure in spontaneously hypertensive rats (SHR) at peroral dose of 5 mg/kg was determined after 6 hr | ChEMBL. | 2879919 |
Reduction (functional) | = 22 % | Percent reduction in blood pressure in spontaneously hypertensive rats (SHR) at peroral dose of 5 mg/kg was determined after 1 hr | ChEMBL. | 2879919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.