Detailed information for compound 265787

Basic information

Technical information
  • TDR Targets ID: 265787
  • Name: 2,4,6,7-tetramethyl-2-[(4-phenylbutylamino)me thyl]-3H-1-benzofuran-5-amine
  • MW: 352.513 | Formula: C23H32N2O
  • H donors: 2 H acceptors: 0 LogP: 4.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c2CC(Oc2c(c(c1N)C)C)(C)CNCCCCc1ccccc1
  • InChi: 1S/C23H32N2O/c1-16-17(2)22-20(18(3)21(16)24)14-23(4,26-22)15-25-13-9-8-12-19-10-6-5-7-11-19/h5-7,10-11,25H,8-9,12-15,24H2,1-4H3
  • InChiKey: TYRCEMWEJLDBAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,4,6,7-tetramethyl-2-[(4-phenylbutylamino)methyl]-3H-benzofuran-5-amine
  • (5-amino-2,4,6,7-tetramethyl-coumaran-2-yl)methyl-(4-phenylbutyl)amine
  • (5-amino-2,4,6,7-tetramethyl-3H-benzofuran-2-yl)methyl-(4-phenylbutyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.0087 0.0223
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0038 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0095 0.0244
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0096 0.0096
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0015 0.0015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0101 0.0259
Onchocerca volvulus 0.0017 0.0024 0.0379
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0095 0.0095
Trichomonas vaginalis set domain proteins, putative 0.0185 0.0627 0.1615
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0001 0.0001
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0024 0.0061
Brugia malayi MH1 domain containing protein 0.002 0.0036 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Brugia malayi MH2 domain containing protein 0.0297 0.1028 0.1028
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.00000010333 0.00000026614
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0151 0.039
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0047 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0001 0.0001
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2797 1 1
Brugia malayi Sugar transporter family protein 0.0017 0.0024 0.0024
Toxoplasma gondii exonuclease III APE 0.0042 0.0114 0.0114
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0059 0.0152
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0101 0.0101
Echinococcus multilocularis musashi 0.0029 0.0069 0.0177
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0033 0.0033
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0095 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0033 0.0033
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0024 0.0024
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1092 0.3882 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0151
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0897
Trypanosoma cruzi hexose transporter, putative 0.002 0.0036 0.0036
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0101 0.0101
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0101 0.0077
Schistosoma mansoni inositol monophosphatase 0.0038 0.0101 0.0101
Schistosoma mansoni smad1 5 8 and 0.002 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.012 0.0393 0.0393
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0033 0.0033
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.2797 1 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0001 0.0009
Loa Loa (eye worm) Smad1 0.002 0.0036 0.035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Loa Loa (eye worm) nuclear factor I 0.0011 0.0004 0.0034
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0059 0.0059
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0059 0.0059
Brugia malayi glutaminase DH11.1 0.0224 0.0767 0.0767
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0092 0.0092
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0236 0.0809 0.0809
Toxoplasma gondii sugar transporter ST1 0.0017 0.0024 0.0024
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0112 0.0364 0.0341
Schistosoma mansoni tar DNA-binding protein 0.0122 0.0401 0.0401
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0092 0.0237
Echinococcus granulosus lamin dm0 0.0029 0.0069 0.0177
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0024 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0009
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0193 0.0657 0.0657
Onchocerca volvulus 0.0017 0.0024 0.0379
Brugia malayi Sugar transporter family protein 0.0017 0.0024 0.0024
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0069 0.0069
Onchocerca volvulus 0.0017 0.0024 0.0379
Plasmodium vivax sugar transporter, putative 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Schistosoma mansoni sugar transporter 0.0017 0.0024 0.0024
Echinococcus multilocularis smad 0.002 0.0036 0.0093
Echinococcus granulosus General substrate transporter 0.0103 0.0332 0.0856
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0114 1
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0096 0.0249
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Echinococcus multilocularis microtubule associated protein 2 0.0715 0.2528 0.6512
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0033 0.002
Entamoeba histolytica hypothetical protein 0.0027 0.0059 0.0152
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0096 0.0096
Schistosoma mansoni inositol monophosphatase 0.0038 0.0101 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0001
Trypanosoma cruzi hexose transporter 0.0037 0.0096 0.0096
Echinococcus multilocularis geminin 0.0194 0.0659 0.1698
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0033 0.0033
Brugia malayi Cam kinase protein 1 0.0037 0.0095 0.0095
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1092 0.3882 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0033 0.0033
Schistosoma mansoni nuclear hormone receptor 0.001 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0151 0.0151
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0193 0.0657 0.0657
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0024 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0044 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0009
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0001 0.0001
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0001 0.0001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0059 0.0576
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0059 0.0152
Onchocerca volvulus 0.0185 0.0627 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0113 0.0113
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0015 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0001
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0009 0.0009
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2797 1 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0095 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0236 0.0809 0.0809
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0101 0.0259
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0096 0.0096
Brugia malayi hypothetical protein 0.0021 0.0038 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0114 0.0114
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0114 0.0114
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0024 0.0061
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0001 0.0001
Schistosoma mansoni Smad4 0.002 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0322
Echinococcus multilocularis TGF beta signal transducer SmadC 0.002 0.0036 0.0093
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0045 0.0032
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0112 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0036 0.0092 0.0897
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0114 0.0114
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0092 0.8082
Trichomonas vaginalis glutaminase, putative 0.0224 0.0767 0.1976
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0092 0.0237
Schistosoma mansoni ap endonuclease 0.0042 0.0114 0.0114
Echinococcus multilocularis solute carrier family 22 0.0017 0.0024 0.0061
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0059 0.0059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0001 0.0003
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0101 0.0259
Schistosoma mansoni smad 0.002 0.0036 0.0036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.001 0.0001 0.0001
Onchocerca volvulus 0.0017 0.0024 0.0379
Schistosoma mansoni protein kinase 0.0037 0.0095 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0033 0.0082 0.0082
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0024 0.0231
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0101 0.0259
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0033 0.0033
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.002 0.002
Plasmodium falciparum mitogen-activated protein kinase 2 0.0193 0.0657 0.0657
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0001 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0009 0.1501
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Schistosoma mansoni sugar transporter 0.0017 0.0024 0.0024
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1092 0.3882 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0024 0.0061
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0024 0.0061
Brugia malayi Pre-SET motif family protein 0.0162 0.0546 0.0546
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2797 1 1
Onchocerca volvulus 0.0029 0.0069 0.1095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0151
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0024 0.0024
Schistosoma mansoni sugar transporter 0.0017 0.0024 0.0024
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.00000010333 0.00000026614
Schistosoma mansoni hypothetical protein 0.0194 0.0659 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0001 0.0001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0001 0.0003
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0059 0.5192
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0033 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0003
Onchocerca volvulus Putative transporter 0.0017 0.0024 0.0379
Echinococcus multilocularis tumor protein p63 0.0814 0.2885 0.7431
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Mycobacterium ulcerans glutaminase 0.0224 0.0767 0.0767
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0047 0.0121
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0001 0.0003
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0024 0.0061
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.2797 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0034
Brugia malayi MH1 domain containing protein 0.002 0.0036 0.0036
Echinococcus multilocularis General substrate transporter 0.0103 0.0332 0.0856
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0014 0.0037
Brugia malayi hypothetical protein 0.0017 0.0024 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0024 0.0061
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0069 0.0668
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0069 0.0668
Loa Loa (eye worm) MH2 domain-containing protein 0.0297 0.1028 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0108 0.0108
Plasmodium vivax CDK-related protein kinase 6, putative 0.0508 0.1785 0.1785
Schistosoma mansoni intermediate filament proteins 0.0029 0.0069 0.0069
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0095 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0024 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0024 0.0061
Entamoeba histolytica protein kinase, putative 0.0037 0.0095 0.0244
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0095 0.0922
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0119
Loa Loa (eye worm) inositol-1 0.0038 0.0101 0.098
Toxoplasma gondii hypothetical protein 0.0038 0.01 0.01
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0059 0.0059
Echinococcus multilocularis Smad4 0.002 0.0036 0.0093
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0151 0.1471
Schistosoma mansoni glucose transport protein 0.012 0.0393 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Onchocerca volvulus 0.0017 0.0024 0.0379
Echinococcus multilocularis mothers against decapentaplegic 5 0.002 0.0036 0.0093
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0001 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0036 0.035
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0095 0.0244
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0114 0.0114
Brugia malayi major facilitator superfamily protein 0.0017 0.0024 0.0024
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0092 0.0092
Echinococcus multilocularis solute carrier family 22 0.0017 0.0024 0.0061
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.084 0.2977 0.7669
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0009
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Giardia lamblia Sugar-proton symporter 0.0017 0.0024 0.2083
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0114 0.0294
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0095 0.0244
Loa Loa (eye worm) TAR-binding protein 0.0122 0.0401 0.3901
Schistosoma mansoni sugar transporter 0.0017 0.0024 0.0024
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0096 0.0096
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0096 0.0249
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0059 0.0059
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0113 0.0113
Schistosoma mansoni thyroid hormone receptor 0.001 0.0001 0.0001
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0322
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0038 0.0038
Echinococcus granulosus tumor protein p63 0.0814 0.2885 0.7431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0151 0.039
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.0087 0.0223
Toxoplasma gondii protein kinase, putative 0.0338 0.1176 0.1176
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0114 0.1109
Echinococcus granulosus microtubule associated protein 2 0.0715 0.2528 0.6512
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0059 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0033 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0033 0.0033
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.0393 0.1011
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0009 0.0779
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.00000010333 0.00000026614
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0047 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0122 0.0401 0.0401
Echinococcus multilocularis lamin 0.0029 0.0069 0.0177
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0038 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Brugia malayi Smad1 0.002 0.0036 0.0036
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0014 0.0037
Schistosoma mansoni protein kinase 0.0037 0.0095 0.0095
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0024 0.0231
Echinococcus granulosus solute carrier family 22 0.0017 0.0024 0.0061
Echinococcus multilocularis lamin dm0 0.0029 0.0069 0.0177
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0001 0.0001
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1092 0.3882 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0113 0.009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0151 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.002 0.0192
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0095 0.0095
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0045 0.0032
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0113 0.009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0151
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1092 0.3882 1
Trypanosoma brucei glucose transporter 1E 0.0037 0.0096 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Echinococcus granulosus solute carrier family 22 0.0017 0.0024 0.0061
Brugia malayi nuclear receptor NHR-88 0.001 0.0001 0.0001
Onchocerca volvulus 0.0017 0.0024 0.0379
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0024 0.0024
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.1092 0.3882 1
Mycobacterium ulcerans sugar transporter 0.0017 0.0024 0.0024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0033 0.0085
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.0393 0.1011
Loa Loa (eye worm) glutaminase 0.0224 0.0767 0.7462
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0122 0.0401 0.3901
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0001
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.2797 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0095 0.0244
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.012 0.0393 0.1011
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0024 0.0061
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Toxoplasma gondii sugar transporter ST3 0.0017 0.0024 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0001 0.0003
Brugia malayi major facilitator superfamily protein 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Loa Loa (eye worm) RNA binding protein 0.0122 0.0401 0.3901
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0038 0.0038
Echinococcus multilocularis solute carrier family 22 0.0017 0.0024 0.0061
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0001 0.0001
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1092 0.3882 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0114 0.0294
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0096 0.0073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0001 0.0003
Onchocerca volvulus 0.0017 0.0024 0.0379
Onchocerca volvulus 0.0017 0.0024 0.0379
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0092 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0038 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Onchocerca volvulus 0.0017 0.0024 0.0379
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.00000010333 0.00000010333
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0033 0.0009
Brugia malayi Pre-SET motif family protein 0.0023 0.0047 0.0047
Giardia lamblia Hexose transporter 0.0017 0.0024 0.2083
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0045 0.0045
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0095 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0095 0.0095
Onchocerca volvulus 0.0017 0.0024 0.0379
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.2797 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0001 0.0009
Brugia malayi RNA recognition motif domain containing protein 0.0122 0.0401 0.0401
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0024 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Trypanosoma brucei glucose transporter 2A 0.0037 0.0096 0.0096
Echinococcus granulosus geminin 0.0194 0.0659 0.1698
Brugia malayi MH1 domain containing protein 0.0011 0.0004 0.0004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.0393 0.1011
Plasmodium vivax SET domain protein, putative 0.0023 0.0047 0.0047
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0024 0.0061
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0113 0.0113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0114 0.0294
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.0393 0.1011
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0059 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Leishmania major glucose transporter, lmgt1 0.0037 0.0096 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0151 0.039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0001 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0114 0.0114
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0096 0.0096
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0001 0.0003
Schistosoma mansoni coup transcription factor 0.001 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0001 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0033 0.0085
Brugia malayi intermediate filament protein 0.0029 0.0069 0.0069
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0059 0.0059
Schistosoma mansoni thyroid hormone receptor 0.001 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0021 0.0038 0.0014
Entamoeba histolytica acyl-coA synthetase, putative 0.0019 0.0033 0.0085
Onchocerca volvulus 0.0029 0.0069 0.1095
Onchocerca volvulus 0.0017 0.0024 0.0379
Brugia malayi Sugar transporter family protein 0.012 0.0393 0.0393
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0086 0.0086
Echinococcus granulosus Smad4 0.002 0.0036 0.0093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0151 0.0151
Brugia malayi hypothetical protein 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0119
Brugia malayi RNA binding protein 0.0122 0.0401 0.0401
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0668
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0236 0.0809 0.0809
Onchocerca volvulus 0.0017 0.0024 0.0379
Toxoplasma gondii ATPase, AAA family protein 0.001 0.00000010333 0.00000010333
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1092 0.3882 1
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0096 0.0249
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0101 0.0259
Trypanosoma brucei sugar transporter, putative 0.0017 0.0024 0.0024
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0095 0.0095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0001 0.0003
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1092 0.3882 0.3882
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.2797 1 1
Echinococcus granulosus solute carrier family 22 0.0017 0.0024 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0033 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0033 0.0082 0.0082
Onchocerca volvulus 0.001 0.0001 0.0015
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0162 0.0546 0.5316
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0001 0.0001
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0095 0.0095
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0001 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0114 0.0114
Brugia malayi Inositol-1 0.0038 0.0101 0.0101
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0095 0.0922
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0033 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0038 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0122 0.0401 0.0401
Echinococcus granulosus replication factor c subunit 1 0.001 0.00000010333 0.00000026614
Schistosoma mansoni glucose transport protein 0.012 0.0393 0.0393
Mycobacterium ulcerans hypothetical protein 0.0019 0.0033 0.0033
Brugia malayi MH1 domain containing protein 0.0011 0.0004 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0038 0.0038
Plasmodium falciparum protein kinase 7 0.0338 0.1176 0.1176
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0151
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0114 0.0294
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0009
Loa Loa (eye worm) sugar transporter 0.0017 0.0024 0.0231
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0033 0.0033
Schistosoma mansoni TGF-beta signal transducer Smad2 0.002 0.0036 0.0036
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0016 0.0158
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0095 0.0244
Loa Loa (eye worm) transcription factor SMAD2 0.0297 0.1028 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0092 0.0237
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.00000010333 0.00000026614
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0095 0.0095
Plasmodium vivax hexose transporter 0.012 0.0393 0.0393
Brugia malayi hypothetical protein 0.0017 0.0024 0.0024
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0059 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0024 0.0011
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0024 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0114 0.0114
Brugia malayi Zinc finger, C2H2 type family protein 0.1092 0.3882 0.3882
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0112 0.0364 0.0364
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0095 0.0244
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0095 0.0244
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0047 0.0122
Schistosoma mansoni glutaminase 0.0224 0.0767 0.0767
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0101 0.0101
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0059 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Plasmodium falciparum dihydroorotate dehydrogenase 0.2797 1 1
Leishmania major glucose transporter, lmgt2 0.0037 0.0096 0.0073
Echinococcus granulosus solute carrier family 22 0.0017 0.0024 0.0061
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0001 0.0015
Brugia malayi TAR-binding protein 0.0122 0.0401 0.0401
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0001 0.0003
Trypanosoma brucei glucose transporter, putative 0.0037 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0322
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.0393 0.1011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0001 0.0003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0101 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0001
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0095 0.0095
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0095 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0024 0.0061
Echinococcus granulosus lamin 0.0029 0.0069 0.0177
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0114 0.0114
Loa Loa (eye worm) glutaminase 2 0.0224 0.0767 0.7462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0033 0.002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1092 0.3882 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0024 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0029 0.0069 0.0177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0001 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0114 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.002 0.0036 0.0093
Toxoplasma gondii sugar transporter ST2 0.0017 0.0024 0.0024
Schistosoma mansoni smad1 5 8 and 0.002 0.0036 0.0036
Onchocerca volvulus 0.0017 0.0024 0.0379
Onchocerca volvulus 0.0017 0.0024 0.0379
Echinococcus multilocularis solute carrier family 22 0.0017 0.0024 0.0061
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0086 0.0074
Schistosoma mansoni glucose transport protein 0.012 0.0393 0.0393
Echinococcus granulosus mothers against decapentaplegic 5 0.002 0.0036 0.0093
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0095 0.0095
Schistosoma mansoni lamin 0.0029 0.0069 0.0069
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.0393 0.1011
Leishmania major mitochondrial DNA polymerase beta 0.0236 0.0809 0.0788
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0122 0.0401 0.0401
Onchocerca volvulus 0.0119 0.0391 0.6237
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0059 1
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0393 0.1011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0101 0.0101
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0095 0.0095
Brugia malayi hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Leishmania major protein kinase, putative 0.0037 0.0095 0.0071
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0015 0.0015 0.2616
Loa Loa (eye worm) hypothetical protein 0.0119 0.0391 0.3804
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.0047 0.0121
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0458
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0138
Echinococcus granulosus smad 0.002 0.0036 0.0093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0124 0.0409 0.0397
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.0393 0.1011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Echinococcus granulosus FTZ F1 alpha 0.001 0.0001 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0095 0.0095
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Schistosoma mansoni cellular tumor antigen P53 0.0119 0.0391 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0096 0.0249
Leishmania major dihydroorotate dehydrogenase 0.2797 1 1
Schistosoma mansoni hypothetical protein 0.0194 0.0659 0.0659
Echinococcus granulosus tar DNA binding protein 0.0122 0.0401 0.1033
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.2797 1 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0096 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0101 0.0259
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1092 0.3882 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2797 1 1
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0096 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0122 0.0401 0.0401
Toxoplasma gondii facilitative glucose transporter GT1 0.012 0.0393 0.0393
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0024 0.0024
Plasmodium vivax acyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Brugia malayi MH2 domain containing protein 0.002 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0096 0.0249
Schistosoma mansoni dihydroorotate dehydrogenase 0.2797 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0231
Plasmodium falciparum acyl-CoA synthetase 0.0015 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0096 0.0249
Onchocerca volvulus 0.0017 0.0024 0.0379
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0047 0.0121
Entamoeba histolytica protein kinase, putative 0.0037 0.0095 0.0244
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0001 0.0015
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0059 0.0036
Mycobacterium ulcerans hypothetical protein 0.0124 0.0409 0.0409
Loa Loa (eye worm) sugar transporter 0.012 0.0393 0.3819
Plasmodium falciparum hexose transporter 0.012 0.0393 0.0393
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0113 0.0113
Leishmania major glucose transporter, lmgt3 0.0037 0.0096 0.0073
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0024 0.0024
Brugia malayi nuclear hormone receptor 0.001 0.0001 0.0001
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0113 0.0113
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0024 0.0061
Echinococcus multilocularis tar DNA binding protein 0.0122 0.0401 0.1033
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0024 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0151 0.039
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Brugia malayi ecdysteroid receptor 0.001 0.0001 0.0001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0114 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Plasmodium falciparum protein kinase 6 0.0508 0.1785 0.1785
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0095 0.0244
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0092 0.0237
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0059 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Schistosoma mansoni glucose transporter 0.0017 0.0024 0.0024
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1092 0.3882 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0068 0.0662
Loa Loa (eye worm) hypothetical protein 0.0037 0.0095 0.0922
Onchocerca volvulus 0.0017 0.0024 0.0379
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0082 0.0082
Echinococcus multilocularis replication factor c subunit 1 0.001 0.00000010333 0.00000026614
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0036 0.035
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.2797 1 1
Schistosoma mansoni ap endonuclease 0.0042 0.0114 0.0114
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0095 0.0095
Schistosoma mansoni lamin 0.0029 0.0069 0.0069
Schistosoma mansoni smad1 5 8 and 0.002 0.0036 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0001 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0047 0.0047
Brugia malayi MH2 domain containing protein 0.002 0.0036 0.0036
Schistosoma mansoni protein kinase 0.0037 0.0095 0.0095
Onchocerca volvulus 0.0023 0.0047 0.075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0067 0.0649
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0114 0.0294
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0082 0.0082
Onchocerca volvulus 0.0019 0.0033 0.0528
Schistosoma mansoni microtubule-associated protein tau 0.0715 0.2528 0.2528
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0024 0.0061
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0114 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0151 0.0151
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0047 0.0047

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.08 uM Concentration required to reduce by 50% the amount of lipid peroxide formed in rat liver microsomes ChEMBL. 9046347
ID50 (functional) = 17 mg kg-1 Peroral dose required to reduce by 50% the score of excitatory behavior induced by intrathecal injection of ferrous chloride in mice ChEMBL. 9046347
ID50 (functional) = 17 mg kg-1 Peroral dose required to reduce by 50% the score of excitatory behavior induced by intrathecal injection of ferrous chloride in mice ChEMBL. 9046347

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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