Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0376 | 0.2246 | 0.2246 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0589 | 0.4318 | 0.4318 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 0.4318 | 0.4318 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Cation transporter family protein | 0.0452 | 0.2983 | 0.2983 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0743 | 0.581 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Cation transporter family protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0312 | 0.1629 | 0.1629 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0312 | 0.1629 | 0.1629 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0589 | 0.4318 | 0.4318 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0168 | 0.0234 | 0.0234 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0632 | 0.4728 | 0.4728 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | tyrosine kinase | 0.1176 | 1 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0168 | 0.0234 | 0.0234 |
Schistosoma mansoni | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | 0.0364 | 0.2132 | 0.2132 | |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0743 | 0.581 | 0.581 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0589 | 0.4318 | 0.4318 |
Schistosoma mansoni | tyrosine kinase | 0.0625 | 0.4663 | 0.4663 |
Onchocerca volvulus | 0.0312 | 0.1629 | 0.3772 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Entamoeba histolytica | hypothetical protein | 0.0168 | 0.0234 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0376 | 0.2246 | 0.2246 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0168 | 0.0234 | 0.0234 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | tyrosine kinase | 0.0625 | 0.4663 | 0.4663 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0168 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Onchocerca volvulus | 0.0312 | 0.1629 | 0.3772 | |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.2287 | 0.2287 |
Echinococcus granulosus | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Onchocerca volvulus | 0.0452 | 0.2983 | 0.6909 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1176 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0376 | 0.2246 | 0.2246 |
Schistosoma mansoni | tyrosine kinase | 0.0632 | 0.4728 | 0.4728 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | tyrosine kinase | 0.0376 | 0.2246 | 0.2246 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | tyrosine kinase | 0.0376 | 0.2246 | 0.2246 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0478 | 0.3238 | 0.3238 |
Loa Loa (eye worm) | ACC-1 protein | 0.0312 | 0.1629 | 0.1629 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0743 | 0.581 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | ACC-1 protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.1589 | 0.1589 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | nAChR subunit | 0.0168 | 0.0234 | 0.0234 |
Onchocerca volvulus | 0.0278 | 0.1296 | 0.3002 | |
Echinococcus granulosus | glycine receptor subunit beta | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | hypothetical protein | 0.022 | 0.0735 | 0.0735 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0478 | 0.3238 | 0.3238 |
Schistosoma mansoni | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.2983 | 0.2983 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0632 | 0.4728 | 0.4728 |
Brugia malayi | Protein kinase domain containing protein | 0.0376 | 0.2246 | 0.2246 |
Schistosoma mansoni | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Onchocerca volvulus | 0.0452 | 0.2983 | 0.6909 | |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0589 | 0.4318 | 0.4318 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0743 | 0.581 | 1 |
Onchocerca volvulus | 0.0312 | 0.1629 | 0.3772 | |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1176 | 1 | 1 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0168 | 0.0234 | 0.0234 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0312 | 0.1629 | 0.1629 |
Echinococcus granulosus | insulin receptor | 0.0376 | 0.2246 | 0.2246 |
Schistosoma mansoni | tyrosine kinase | 0.0625 | 0.4663 | 0.4663 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0632 | 0.4728 | 0.4728 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0168 | 0.0234 | 0.0234 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.581 | 0.581 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0589 | 0.4318 | 0.4318 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0589 | 0.4318 | 0.4318 |
Schistosoma mansoni | tyrosine kinase | 0.0632 | 0.4728 | 0.4728 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0478 | 0.3238 | 0.3238 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0312 | 0.1629 | 0.1629 |
Echinococcus granulosus | nAChR subunit | 0.0168 | 0.0234 | 0.0234 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0452 | 0.2983 | 0.2983 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0312 | 0.1629 | 0.1629 |
Onchocerca volvulus | 0.0452 | 0.2983 | 0.6909 | |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0478 | 0.3238 | 0.3238 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | LGC-31 protein | 0.0312 | 0.1629 | 0.1629 |
Onchocerca volvulus | Putative nachr subunit | 0.0589 | 0.4318 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1176 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0452 | 0.2983 | 0.2983 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0589 | 0.4318 | 0.4318 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Brugia malayi | Cation transporter family protein | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | insulin receptor | 0.0376 | 0.2246 | 0.2246 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0312 | 0.1629 | 0.1629 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0168 | 0.0234 | 0.0234 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 0.2983 | 0.2983 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0312 | 0.1629 | 0.1629 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0589 | 0.4318 | 0.4318 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0234 | 0.0234 |
Onchocerca volvulus | 0.0168 | 0.0234 | 0.0542 | |
Onchocerca volvulus | 0.0168 | 0.0234 | 0.0542 | |
Echinococcus multilocularis | nAChR subunit | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0312 | 0.1629 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0312 | 0.1629 | 0.1629 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0168 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1629 | 0.1629 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log SP (functional) | NA 0 | Sweet potency as logarithm of sweet potency (log SP) relative to sucrose; No sweet | ChEMBL. | 7241515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.