Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Brugia malayi | nuclear hormone receptor | Get druggable targets OG5_131607 | All targets in OG5_131607 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glyoxalase GloA | 0.0044 | 0.0084 | 1 |
Schistosoma mansoni | gynecophoral canal protein | 0.0044 | 0.0084 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0044 | 0.0084 | 1 |
Toxoplasma gondii | glyoxalase family protein | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0044 | 0.0084 | 1 |
Plasmodium vivax | glyoxalase I, putative | 0.0044 | 0.0084 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0044 | 0.0084 | 0.5 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0044 | 0.0084 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0084 | 0.0086 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0044 | 0.0084 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0044 | 0.0084 | 1 |
Onchocerca volvulus | Putative protein | 0.0298 | 0.3395 | 0.3339 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0084 | 0.5 |
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.0298 | 0.3395 | 0.3482 |
Mycobacterium leprae | conserved hypothetical protein | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0787 | 0.9748 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Brugia malayi | lactoylglutathione lyase | 0.0044 | 0.0084 | 0.0086 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0044 | 0.0084 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0044 | 0.0084 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9524 | 0.9769 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0084 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0037 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0787 | 0.9748 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0044 | 0.0084 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0044 | 0.0084 | 1 |
Schistosoma mansoni | 4-hydroxyphenylpyruvate dioxygenase | 0.0044 | 0.0084 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0044 | 0.0084 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Brugia malayi | 4-hydroxyphenylpyruvate dioxygenase family protein | 0.0298 | 0.3395 | 0.3482 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.0084 | 1 |
Toxoplasma gondii | glyoxalase I, putative | 0.0044 | 0.0084 | 1 |
Plasmodium vivax | glyoxalase I, putative | 0.0044 | 0.0084 | 0.5 |
Echinococcus multilocularis | 0.0037 | 0 | 0.5 | |
Leishmania major | glyoxalase I,trypanothione-dependent glyoxalase I | 0.0044 | 0.0084 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 274 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 274 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 408 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 408 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 1051 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay | ChEMBL. | 10098666 |
Kd (binding) | = 1051 nM | Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay | ChEMBL. | 10098666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.