Detailed information for compound 265942

Basic information

Technical information
  • TDR Targets ID: 265942
  • Name: (E)-3-(4-hexadecoxyphenyl)prop-2-enoic acid
  • MW: 388.583 | Formula: C25H40O3
  • H donors: 1 H acceptors: 2 LogP: 9.6 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCOc1ccc(cc1)/C=C/C(=O)O
  • InChi: 1S/C25H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-22-28-24-19-16-23(17-20-24)18-21-25(26)27/h16-21H,2-15,22H2,1H3,(H,26,27)/b21-18+
  • InChiKey: NVJKETMILSTWAT-DYTRJAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-3-(4-hexadecoxyphenyl)-2-propenoic acid
  • (E)-3-(4-cetyloxyphenyl)acrylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Schistosoma mansoni protein kinase C mu 0.0093 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus tachykinin peptides receptor 99D 0.016 0.0336 0.0311
Brugia malayi Peroxidasin 0.0238 0.0524 0.05
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.016 0.0336 0.0336
Echinococcus multilocularis tyrosine protein kinase HCK 0.0047 0.0064 0.0039
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi neuropeptide F receptor 0.016 0.0336 0.0311
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0058 0.0032
Loa Loa (eye worm) TK protein kinase 0.0047 0.0064 0.0039
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis c src tyrosine kinase 0.0035 0.0035 0.0009
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Loa Loa (eye worm) neuropeptide F receptor 0.016 0.0336 0.0311
Schistosoma mansoni amine GPCR 0.016 0.0336 0.0336
Schistosoma mansoni amine GPCR 0.016 0.0336 0.0336
Echinococcus granulosus neuropeptide Y receptor 0.016 0.0336 0.0311
Schistosoma mansoni tyrosine kinase 0.0031 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Schistosoma mansoni tyrosine kinase 0.046 0.106 0.106
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0058 0.0033
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus unc 13 munc13 0.0093 0.0174 0.0149
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0093 0.0174 0.0149
Brugia malayi Serotonin receptor 0.016 0.0336 0.0311
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0107 0.0209 0.0184
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.4161 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.016 0.0336 0.0311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Loa Loa (eye worm) melatonin receptor type 1A 0.016 0.0336 0.0311
Schistosoma mansoni biogenic amine receptor 0.016 0.0336 0.0336
Brugia malayi ORL1-like opioid receptor 0.016 0.0336 0.0311
Brugia malayi Raf kinase 0.2576 0.6172 0.6163
Echinococcus multilocularis orexin receptor type 2 0.016 0.0336 0.0311
Echinococcus granulosus tm gpcr rhodopsin 0.016 0.0336 0.0311
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.0058 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.0336 0.0311
Echinococcus granulosus neuropeptide s receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus serotonin receptor 0.016 0.0336 0.0311
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.016 0.0336 0.0336
Brugia malayi cell division control protein 2 homolog 0.0045 0.0058 0.0033
Echinococcus multilocularis G-protein coupled receptor, putative 0.016 0.0336 0.0311
Brugia malayi Dopamine receptor protein 1 0.016 0.0336 0.0311
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Brugia malayi gonadotropin-releasing hormone receptor 2 0.016 0.0336 0.0311
Toxoplasma gondii diacylglycerol kinase, putative 0.0093 0.0174 0.0117
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) animal heme peroxidase 0.0238 0.0524 0.05
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0035 0.0035 0.0009
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0062 0.0099 0.0074
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.016 0.0336 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.198 0.4731 1
Schistosoma mansoni unc-13 (munc13) 0.0093 0.0174 0.0174
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.0058 0.0033
Echinococcus granulosus c src tyrosine kinase 0.0035 0.0035 0.0009
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Brugia malayi putative neuropeptide receptor 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0058 0.0033
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.016 0.0336 0.0336
Echinococcus granulosus dro:myosuppressin receptor 0.016 0.0336 0.0311
Echinococcus granulosus g protein coupled receptor 0.016 0.0336 0.0311
Echinococcus granulosus neuropeptide Y receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.0099 0.0074
Echinococcus granulosus fmrfamide receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) SRC-1 0.0066 0.0108 0.0083
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.0058 0.0033
Echinococcus multilocularis allatostatin A receptor 0.016 0.0336 0.0311
Echinococcus granulosus 7TM GPCR rhodopsin 0.016 0.0336 0.0311
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0093 0.0174 0.0149
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.4161 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.016 0.0336 0.0311
Onchocerca volvulus 0.0238 0.0524 0.05
Echinococcus multilocularis serotonin receptor 0.016 0.0336 0.0311
Schistosoma mansoni amine GPCR 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus 0.4161 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.016 0.0336 0.0311
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.016 0.0336 0.0311
Schistosoma mansoni atypical protein kinase C 0.0093 0.0175 0.0175
Schistosoma mansoni biogenic amine (5HT) receptor 0.016 0.0336 0.0336
Onchocerca volvulus 0.016 0.0336 0.0311
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.1515 0.3609 0.3593
Schistosoma mansoni tyrosine kinase 0.0066 0.0108 0.0108
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0386 0.0883 0.086
Brugia malayi Protein kinase domain containing protein 0.0045 0.0058 0.0033
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.4161 1 1
Onchocerca volvulus 0.016 0.0336 0.0311
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Entamoeba histolytica protein kinase, putative 0.0047 0.0064 0.2602
Echinococcus granulosus thyrotropin releasing hormone receptor 0.016 0.0336 0.0311
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0058 0.0058
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0093 0.0175 0.015
Schistosoma mansoni vav2 0.0107 0.0209 0.0209
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.016 0.0336 0.0311
Loa Loa (eye worm) thymidylate synthase 0.4161 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.016 0.0336 0.0311
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Onchocerca volvulus Chorion peroxidase homolog 0.0238 0.0524 0.05
Echinococcus granulosus myotubularin protein 13 0.0093 0.0174 0.0149
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.016 0.0336 0.0311
Echinococcus granulosus protein kinase c iota type 0.0093 0.0175 0.015
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) G-protein coupled receptor 0.016 0.0336 0.0311
Onchocerca volvulus Peroxidasin homolog 0.0238 0.0524 0.05
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus Neuropeptide F receptor homolog 0.016 0.0336 0.0311
Brugia malayi Serotonin/octopamine receptor family protein 7 0.016 0.0336 0.0311
Echinococcus multilocularis sex peptide receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.016 0.0336 0.0311
Brugia malayi diacylglycerol kinase 0.0093 0.0174 0.0149
Brugia malayi follicle stimulating hormone receptor 0.0386 0.0883 0.086
Echinococcus granulosus g protein coupled receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.0108 0.0083
Brugia malayi GnHR receptor homolog 0.016 0.0336 0.0311
Echinococcus granulosus peroxidasin 0.0238 0.0524 0.05
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Schistosoma mansoni hypothetical protein 0.0093 0.0174 0.0174
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0107 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis tyrosine protein kinase Blk 0.0062 0.0099 0.0074
Schistosoma mansoni growth hormone secretagogue receptor 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Schistosoma mansoni rac gtpase activating protein 0.0093 0.0174 0.0174
Loa Loa (eye worm) animal heme peroxidase 0.0238 0.0524 0.05
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0093 0.0175 0.015
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0234 0.0209
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.0058 0.0033
Echinococcus multilocularis peroxidasin 0.0238 0.0524 0.05
Echinococcus granulosus biogenic amine 5HT receptor 0.016 0.0336 0.0311
Schistosoma mansoni diacylglycerol kinase theta 0.0093 0.0174 0.0174
Echinococcus granulosus g-protein coupled receptor 0.016 0.0336 0.0311
Echinococcus granulosus tyrosine protein kinase Src42A 0.0066 0.0108 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.0108 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Echinococcus granulosus G protein coupled receptor 139 0.016 0.0336 0.0311
Brugia malayi G-protein coupled receptor 0.016 0.0336 0.0311
Entamoeba histolytica hypothetical protein 0.0093 0.0174 1
Schistosoma mansoni neuropeptide receptor 0.016 0.0336 0.0336
Mycobacterium ulcerans thymidylate synthase 0.4161 1 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.016 0.0336 0.0336
Loa Loa (eye worm) neuropeptide F receptor 0.016 0.0336 0.0311
Entamoeba histolytica diacylglycerol kinase, putative 0.0093 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Brugia malayi Animal haem peroxidase family protein 0.0238 0.0524 0.05
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.0336 0.0311
Schistosoma mansoni peptide (allatostatin)-like receptor 0.016 0.0336 0.0336
Brugia malayi RhoGAP domain containing protein 0.0107 0.0209 0.0184
Echinococcus granulosus neuropeptide FF receptor 2 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Echinococcus granulosus tyrosine protein kinase Src64B 0.0066 0.0108 0.0083
Brugia malayi SRC-1 0.0066 0.0108 0.0083
Echinococcus multilocularis neuropeptide Y receptor 0.016 0.0336 0.0311
Schistosoma mansoni myosin xvIII 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Schistosoma mansoni peroxidasin 0.0238 0.0524 0.0524
Echinococcus multilocularis g protein coupled receptor 0.016 0.0336 0.0311
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.0108 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.0336 0.0311
Echinococcus granulosus hypothetical protein 0.016 0.0336 0.0311
Schistosoma mansoni amine GPCR 0.016 0.0336 0.0336
Echinococcus granulosus peptide allatostatin:somatostatin 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Schistosoma mansoni tyrosine kinase 0.0035 0.0035 0.0035
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0093 0.0175 0.015
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0035 0.0035 0.0035
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.0058 0.0033
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.0336 0.0311
Brugia malayi hypothetical protein 0.0238 0.0524 0.05
Echinococcus multilocularis fmrfamide receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus protein kinase c epsilon type 0.0093 0.0175 0.015
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Entamoeba histolytica diacylglycerol kinase, putative 0.0093 0.0174 1
Echinococcus multilocularis neuropeptide s receptor 0.016 0.0336 0.0311
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.0336 0.0311
Schistosoma mansoni hypothetical protein 0.016 0.0336 0.0336
Echinococcus granulosus tyrosine protein kinase HCK 0.0047 0.0064 0.0039
Brugia malayi G protein-coupled receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Echinococcus multilocularis neuropeptide receptor A26 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Echinococcus multilocularis g-protein coupled receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) TYRA-2 protein 0.016 0.0336 0.0311
Schistosoma mansoni serine/threonine protein kinase 0.2669 0.6397 0.6397
Echinococcus granulosus cyclin dependent kinase 0.0045 0.0058 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.016 0.0336 0.0311
Echinococcus multilocularis somatostatin receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0107 0.0209 0.0184
Onchocerca volvulus 0.016 0.0336 0.0311
Echinococcus granulosus g protein coupled receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Onchocerca volvulus 0.016 0.0336 0.0311
Brugia malayi Blistered cuticle protein 3 0.0238 0.0524 0.05
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0035 0.0035 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Brugia malayi hypothetical protein 0.198 0.4731 0.4717
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.4161 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0062 0.0099 0.0074
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0066 0.0108 0.0083
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0093 0.0174 0.0149
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.4161 1 0.5
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus granulosus N chimaerin 0.0107 0.0209 0.0184
Schistosoma mansoni neuropeptide receptor 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Echinococcus multilocularis myotubularin protein 13 0.0093 0.0174 0.0149
Schistosoma mansoni unc-13 (munc13) 0.0093 0.0174 0.0174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Brugia malayi Animal haem peroxidase family protein 0.0238 0.0524 0.05
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0058 0.5
Brugia malayi diacylglycerol kinase 0.0093 0.0174 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus Peroxidasin homolog 0.0238 0.0524 0.05
Onchocerca volvulus 0.016 0.0336 0.0311
Onchocerca volvulus 0.0093 0.0174 0.0149
Schistosoma mansoni opsin-like receptor 0.016 0.0336 0.0336
Schistosoma mansoni tyrosine kinase 0.0474 0.1095 0.1095
Brugia malayi Ras association domain family 1 isoform A 0.0093 0.0174 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Loa Loa (eye worm) TK protein kinase 0.0062 0.0099 0.0074
Echinococcus multilocularis neuropeptide Y receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) RasGEF domain-containing protein 0.0093 0.0174 0.0149
Brugia malayi Serotonin receptor 0.016 0.0336 0.0311
Brugia malayi Animal haem peroxidase family protein 0.0238 0.0524 0.05
Echinococcus granulosus neuropeptides capa receptor 0.016 0.0336 0.0311
Echinococcus multilocularis unc 13 (munc13) 0.0093 0.0174 0.0149
Schistosoma mansoni amine GPCR 0.016 0.0336 0.0336
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0175 0.0175
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis neuropeptide receptor 0.016 0.0336 0.0311
Echinococcus multilocularis g protein coupled receptor 0.016 0.0336 0.0311
Brugia malayi Variant SH3 domain containing protein 0.0107 0.0209 0.0184
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0058 0.2202
Echinococcus multilocularis Rac GTPase activating protein 1 0.0093 0.0174 0.0149
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi larval opioid receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi Protein kinase c protein 2 0.0093 0.0175 0.015
Brugia malayi neuropeptide F receptor 0.016 0.0336 0.0311
Echinococcus granulosus neuropeptides capa receptor 0.016 0.0336 0.0311
Schistosoma mansoni opsin-like receptor 0.016 0.0336 0.0336
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus 0.0238 0.0524 0.05
Schistosoma mansoni histamine h1 receptor 0.016 0.0336 0.0336
Brugia malayi protein kinase C3,putative 0.0093 0.0175 0.015
Echinococcus multilocularis Diacylglycerol kinase theta 0.0093 0.0174 0.0149
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus Peroxidase homolog 0.0238 0.0524 0.05
Brugia malayi Dopamine receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0093 0.0175 0.015
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0107 0.0209 0.0184
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0066 0.0108 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Brugia malayi G-protein coupled receptor 0.016 0.0336 0.0311
Echinococcus multilocularis tyrosine protein kinase Abl 0.0035 0.0035 0.0009
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi Tachykinin-like peptides receptor 99D 0.016 0.0336 0.0311
Echinococcus granulosus neuropeptide receptor 0.016 0.0336 0.0311
Echinococcus multilocularis neuropeptides capa receptor 0.016 0.0336 0.0311
Echinococcus multilocularis g protein coupled receptor 0.016 0.0336 0.0311
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0093 0.0175 0.015
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Echinococcus multilocularis protein kinase c epsilon type 0.0093 0.0175 0.015
Schistosoma mansoni neuropeptide f receptor 76f 0.016 0.0336 0.0336
Schistosoma mansoni biogenic amine (5HT) receptor 0.016 0.0336 0.0336
Schistosoma mansoni neuropeptide receptor 0.016 0.0336 0.0336
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0058 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Brugia malayi Dopamine receptor protein 2 0.016 0.0336 0.0311
Echinococcus multilocularis protein kinase c iota type 0.0093 0.0175 0.015
Onchocerca volvulus 0.016 0.0336 0.0311
Schistosoma mansoni hypothetical protein 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.016 0.0336 0.0336
Echinococcus granulosus Diacylglycerol kinase theta 0.0093 0.0174 0.0149
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi Protein kinase domain containing protein 0.0093 0.0175 0.015
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Echinococcus granulosus tyrosine protein kinase shark 0.0474 0.1095 0.1072
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0066 0.0108 0.0083
Brugia malayi C1-like domain containing protein 0.0093 0.0175 0.015
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.016 0.0336 0.0336
Echinococcus granulosus allatostatin A receptor 0.016 0.0336 0.0311
Brugia malayi MH2 domain containing protein 0.0118 0.0234 0.0209
Echinococcus granulosus rhodopsin orphan GPCR 0.016 0.0336 0.0311
Brugia malayi RhoGAP domain containing protein 0.0093 0.0174 0.0149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.0108 0.0083
Brugia malayi Animal haem peroxidase family protein 0.0238 0.0524 0.05
Brugia malayi Animal haem peroxidase family protein 0.0238 0.0524 0.05
Onchocerca volvulus 0.016 0.0336 0.0311
Schistosoma mansoni biogenic amine (dopamine) receptor 0.016 0.0336 0.0336
Brugia malayi RE15519p 0.016 0.0336 0.0311
Loa Loa (eye worm) blistered cuticle protein 3 0.0238 0.0524 0.05
Echinococcus granulosus protein kinase c eta type 0.0093 0.0174 0.0149
Echinococcus granulosus raf serine:threonine protein kinase 0.2669 0.6397 0.6388
Brugia malayi sulfakinin receptor protein 0.016 0.0336 0.0311
Echinococcus multilocularis G protein coupled receptor 139 0.016 0.0336 0.0311
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Schistosoma mansoni biogenic amine receptor 0.016 0.0336 0.0336
Echinococcus multilocularis rhodopsin orphan GPCR 0.016 0.0336 0.0311
Echinococcus multilocularis neuropeptides capa receptor 0.016 0.0336 0.0311
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.0058 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.016 0.0336 0.0311
Loa Loa (eye worm) raf kinase 0.2652 0.6356 0.6346
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.4161 1 1
Onchocerca volvulus 0.016 0.0336 0.0311
Echinococcus multilocularis dro:myosuppressin receptor 0.016 0.0336 0.0311
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.4161 1 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Echinococcus granulosus tyrosine kinase 0.0062 0.0099 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.016 0.0336 0.0336
Echinococcus granulosus 7tm_1 domain containing protein 0.016 0.0336 0.0311
Brugia malayi RhoGEF domain containing protein 0.0093 0.0174 0.0149
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.016 0.0336 0.0311
Brugia malayi protein-tyrosine kinase 0.0062 0.0099 0.0074
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0066 0.0108 0.0083
Echinococcus multilocularis serotonin receptor 0.016 0.0336 0.0311
Echinococcus granulosus tm gpcr rhodopsin 0.016 0.0336 0.0311
Echinococcus multilocularis neuropeptide receptor 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Onchocerca volvulus 0.016 0.0336 0.0311
Echinococcus multilocularis N chimaerin 0.0107 0.0209 0.0184
Echinococcus granulosus neuropeptide receptor A26 0.016 0.0336 0.0311
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0093 0.0174 0.0149
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.4161 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.016 0.0336 0.0311
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.0058 0.0033
Schistosoma mansoni tyrosine kinase 0.0035 0.0035 0.0035
Echinococcus multilocularis fmrfamide receptor 0.016 0.0336 0.0311
Schistosoma mansoni hypothetical protein 0.016 0.0336 0.0336
Schistosoma mansoni protein kinase C mu 0.0093 0.0174 0.0174
Schistosoma mansoni neuropeptide receptor 0.016 0.0336 0.0336
Echinococcus multilocularis thymidylate synthase 0.4161 1 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Onchocerca volvulus 0.0238 0.0524 0.05
Schistosoma mansoni biogenic amine (dopamine) receptor 0.016 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0175 0.0175
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0093 0.0175 0.015
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Schistosoma mansoni hypothetical protein 0.016 0.0336 0.0336
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0175 0.0175
Schistosoma mansoni neuropeptide F-like receptor 0.016 0.0336 0.0336
Brugia malayi Tyrosine-protein kinase abl-1 0.0035 0.0035 0.0009
Onchocerca volvulus Peroxidase homolog 0.0238 0.0524 0.05
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0066 0.0108 0.0083
Schistosoma mansoni peroxidasin 0.0238 0.0524 0.0524
Loa Loa (eye worm) G-protein coupled receptor 0.016 0.0336 0.0311
Brugia malayi G protein-coupled receptor F59B2.13 0.016 0.0336 0.0311
Echinococcus granulosus tyrosine protein kinase Blk 0.0062 0.0099 0.0074
Echinococcus granulosus biogenic amine 5HT receptor 0.016 0.0336 0.0311
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0066 0.0108 0.0083
Schistosoma mansoni biogenic amine receptor 0.016 0.0336 0.0336
Schistosoma mansoni tyrosine kinase 0.0066 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Onchocerca volvulus 0.0093 0.0174 0.0149
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.016 0.0336 0.0311
Echinococcus granulosus tyrosine protein kinase Lyn 0.0066 0.0109 0.0084
Schistosoma mansoni opsin-like receptor 0.016 0.0336 0.0336
Echinococcus granulosus somatostatin receptor 0.016 0.0336 0.0311
Echinococcus granulosus Protein kinase C brain isozyme 0.0093 0.0175 0.015
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Brugia malayi Melatonin receptor type 1A 0.016 0.0336 0.0311
Echinococcus granulosus neuropeptide receptor 0.016 0.0336 0.0311
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.016 0.0336 0.0311
Echinococcus multilocularis raf serine:threonine protein kinase 0.2669 0.6397 0.6388
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0175 0.0175
Schistosoma mansoni adenoreceptor 0.016 0.0336 0.0336
Brugia malayi protein kinase C II. 0.0093 0.0175 0.015
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.016 0.0336 0.0311
Echinococcus granulosus sex peptide receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.016 0.0336 0.0311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.016 0.0336 0.0311
Echinococcus granulosus Rac GTPase activating protein 1 0.0093 0.0174 0.0149
Loa Loa (eye worm) animal heme peroxidase 0.0238 0.0524 0.05
Loa Loa (eye worm) hypothetical protein 0.0238 0.0524 0.05
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Brugia malayi putative neuropeptide receptor NPR1 0.016 0.0336 0.0311
Echinococcus granulosus thymidylate synthase 0.4161 1 1
Onchocerca volvulus Dual oxidase homolog 0.0238 0.0524 0.05
Echinococcus granulosus alpha 1A adrenergic receptor 0.016 0.0336 0.0311
Echinococcus multilocularis alpha 1A adrenergic receptor 0.016 0.0336 0.0311
Schistosoma mansoni protein kinase C 0.0093 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Onchocerca volvulus 0.0093 0.0174 0.0149
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.0058 0.2202
Loa Loa (eye worm) hypothetical protein 0.0044 0.0057 0.0032
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0066 0.0108 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.0108 0.0083
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0234 0.0209
Loa Loa (eye worm) animal heme peroxidase 0.0238 0.0524 0.05
Giardia lamblia Kinase, CMGC CDK 0.0045 0.0058 0.5
Echinococcus granulosus orexin receptor type 2 0.016 0.0336 0.0311
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0066 0.0108 0.0083
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.0058 0.0033
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.198 0.4731 0.47
Brugia malayi hypothetical protein 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.016 0.0336 0.0311
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.016 0.0336 0.0311
Leishmania major dihydrofolate reductase-thymidylate synthase 0.4161 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.0108 0.0083
Echinococcus multilocularis neuropeptide FF receptor 2 0.016 0.0336 0.0311
Loa Loa (eye worm) hypothetical protein 0.0093 0.0174 0.0149
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.016 0.0336 0.0336
Schistosoma mansoni diacylglycerol kinase theta 0.0093 0.0174 0.0174
Schistosoma mansoni alpha-1 adrenergic receptor 0.016 0.0336 0.0336
Onchocerca volvulus 0.016 0.0336 0.0311
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0107 0.0209 0.0209
Schistosoma mansoni biogenic amine (dopamine) receptor 0.016 0.0336 0.0336
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.016 0.0336 0.0311
Brugia malayi AKH receptor 0.016 0.0336 0.0311
Brugia malayi Pleckstrin Homology Domain 0.0093 0.0174 0.0149
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0093 0.0175 0.015
Echinococcus multilocularis tyrosine protein kinase shark 0.0474 0.1095 0.1072
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0175 0.0175
Echinococcus multilocularis protein kinase c eta type 0.0093 0.0174 0.0149
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.016 0.0336 0.0311

Activities

Activity type Activity value Assay description Source Reference
Decrease (functional) = 1 % In vivo hypolipidemic activity, expressed as percent decrease in serum cholesterol in rat, at dosage of 20 mg for 7 days. ChEMBL. 7359513
Decrease (functional) = 2 % In vivo hypolipidemic activity, expressed as percent decrease in serum cholesterol in rat, at dosage of 20 mg for 7 days. ChEMBL. 7359513
Decrease (functional) = 2 % Tested for the hypolipidemic activity, expressed as percent decrease in Triglyceride in rat, at dosage of 10 mg for 7 days by Ryan and Rasho method ChEMBL. 7359513
Decrease (functional) = 7 % Tested for the hypolipidemic activity, expressed as percent decrease in serum cholesterol in rat, at dosage of 10 mg for 7 days by Zak et al method ChEMBL. 7359513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.