Detailed information for compound 26605

Basic information

Technical information
  • TDR Targets ID: 26605
  • Name: 1-(benzhydrylsulfamoyl)-3-[2,6-di(propan-2-yl )phenyl]urea
  • MW: 465.608 | Formula: C26H31N3O3S
  • H donors: 3 H acceptors: 3 LogP: 6.22 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NS(=O)(=O)NC(c1ccccc1)c1ccccc1)Nc1c(cccc1C(C)C)C(C)C
  • InChi: 1S/C26H31N3O3S/c1-18(2)22-16-11-17-23(19(3)4)25(22)27-26(30)29-33(31,32)28-24(20-12-7-5-8-13-20)21-14-9-6-10-15-21/h5-19,24,28H,1-4H3,(H2,27,29,30)
  • InChiKey: ZQBCYEBALAGHNN-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(benzhydrylsulfamoyl)-3-(2,6-diisopropylphenyl)urea
  • 3-[di(phenyl)methylsulfamoyl]-1-[2,6-di(propan-2-yl)phenyl]urea
  • 1-(2,6-diisopropylphenyl)-3-[di(phenyl)methylsulfamoyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis neuroendocrine convertase 2 0.009 0.0354 0.1081
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Brugia malayi MBOAT family protein 0.0026 0.0049 0.0235
Brugia malayi ImpB/MucB/SamB family protein 0.009 0.0355 0.1856
Schistosoma mansoni peroxidasin 0.0026 0.005 0.0141
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0017 0.0389
Mycobacterium tuberculosis Probable dehydrogenase 0.0233 0.1038 0.1335
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0017 0.0061
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.022 0.5124
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0057 0.0199 0.06
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0199 0.4586
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2108 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0095 0.0477
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0095 0.1958
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.022 0.5124
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.022 0.6035
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0199 0.4586
Loa Loa (eye worm) hhat protein 0.0026 0.0049 0.0205
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Schistosoma mansoni hypothetical protein 0.0694 0.3242 1
Loa Loa (eye worm) proprotein convertase 2 0.0034 0.0087 0.038
Loa Loa (eye worm) hypothetical protein 0.0057 0.0199 0.0898
Loa Loa (eye worm) hypothetical protein 0.0036 0.0096 0.0422
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0057 0.0199 0.06
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0057 0.0199 0.06
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0049 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0049 0.0389
Trichomonas vaginalis pc-MYB2, putative 0.0059 0.0209 0.5679
Loa Loa (eye worm) RNA binding protein 0.0066 0.0242 0.1098
Brugia malayi MH2 domain containing protein 0.0025 0.0047 0.0226
Echinococcus granulosus dna polymerase kappa 0.0062 0.022 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0049 0.0137
Schistosoma mansoni DNA polymerase eta 0.009 0.0355 0.1084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0107 0.0473
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0057 0.0199 0.06
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0095 0.0078
Echinococcus granulosus thioredoxin glutathione reductase 0.0102 0.0413 0.1263
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.003 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Giardia lamblia Furin precursor putative serine protease 0.0028 0.0058 0.0189
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.0355 0.8543
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0175 0.09
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0057 0.0199 0.4586
Giardia lamblia hypothetical protein 0.0057 0.0199 0.0844
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0159 0.3584
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.005 0.021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.022 0.0996
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0057 0.0199 0.06
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Schistosoma mansoni hypothetical protein 0.0107 0.0438 0.1341
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Loa Loa (eye worm) hypothetical protein 0.0057 0.0199 0.0898
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0412 0.1896 0.8739
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0209 0.5679
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0049 0.0137
Trichomonas vaginalis pc-MYB2, putative 0.0059 0.0209 0.5679
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0057 0.0199 0.4586
Entamoeba histolytica hypothetical protein 0.0107 0.0438 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Echinococcus granulosus chromobox protein 1 0.0068 0.0249 0.0755
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.022 0.5124
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0233 0.1038 0.1335
Plasmodium falciparum glutathione reductase 0.0035 0.0095 0.1958
Echinococcus granulosus Smad4 0.0025 0.0047 0.0132
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0037 0.0172
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.022 0.0666
Brugia malayi Animal haem peroxidase family protein 0.0026 0.005 0.0241
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0242 0.1098
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0049 0.0137
Brugia malayi MBOAT family protein 0.0026 0.0049 0.0235
Loa Loa (eye worm) RecQ helicase 0.0023 0.0037 0.0151
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Loa Loa (eye worm) hypothetical protein 0.0117 0.0486 0.2227
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0017 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0199 0.5332
Onchocerca volvulus Peroxidasin homolog 0.0026 0.005 0.0152
Brugia malayi RNA binding protein 0.0066 0.0242 0.1256
Trichomonas vaginalis MYB3r3, putative 0.0059 0.0209 0.5679
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0095 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0373 0.1708 0.787
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0594 0.2766 0.2822
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0087 0.164
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0205
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0087 0.164
Leishmania major glycerol uptake protein, putative 0.0026 0.0049 0.0803
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0249 0.6989
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.0413 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.1187 0.3653
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0438 0.1341
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0049 0.0389
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0095 0.1958
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0087 0.164
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.1187 0.3653
Echinococcus granulosus Furin 1 0.0034 0.0087 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0057 0.0199 0.06
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.022 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.2303
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0233 0.1038 0.1335
Schistosoma mansoni hypothetical protein 0.0694 0.3242 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0049 0.0205
Echinococcus multilocularis chromobox protein 1 0.0068 0.0249 0.0755
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0199 0.4586
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0049 0.0389
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0057 0.0199 0.06
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Schistosoma mansoni peroxidasin 0.0026 0.005 0.0141
Toxoplasma gondii hypothetical protein 0.0026 0.0049 0.0176
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0057 0.0199 0.06
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0057 0.0199 0.1027
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0057 0.0199 0.4586
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.008
Echinococcus multilocularis chromobox protein 1 0.0068 0.0249 0.0755
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0049 0.0176
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0159 0.3584
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0469 0.2169 0.6686
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0242 0.1098
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0242 0.0734
Loa Loa (eye worm) hypothetical protein 0.0049 0.0159 0.0714
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0594 0.2766 0.2753
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0057 0.0199 0.06
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0159 0.3584
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Mycobacterium tuberculosis Probable reductase 0.0233 0.1038 0.1335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0028 0.0058 0.0678
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.4796
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0057 0.0199 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0047 0.0197
Toxoplasma gondii thioredoxin reductase 0.0102 0.0413 0.1494
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0095 0.1958
Echinococcus granulosus dna polymerase eta 0.009 0.0355 0.1084
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0469 0.2169 0.7842
Echinococcus multilocularis 0.0115 0.0476 0.1456
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0249 0.6989
Plasmodium falciparum phosphodiesterase gamma, putative 0.0057 0.0199 0.4586
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0057 0.0199 0.06
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0199 0.4586
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0095 0.0078
Trypanosoma brucei trypanothione reductase 0.0102 0.0413 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0199 0.4586
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0049 0.0137
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.005 0.021
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0292
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0095 0.0279
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.4586
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0057 0.0199 0.06
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0209 0.5679
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0121 0.2757
Trichomonas vaginalis MYB72, putative 0.0059 0.0209 0.5679
Giardia lamblia Myb 1-like protein 0.006 0.021 0.0899
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0095 0.1958
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0049 0.0137
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Schistosoma mansoni smad 0.0025 0.0047 0.0132
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.034 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0259 0.1162 0.1511
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0159 0.0575
Brugia malayi hypothetical protein 0.0107 0.0438 0.2294
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0152 0.0551
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0233 0.1038 0.1335
Leishmania major hypothetical protein, conserved 0.0026 0.0049 0.0803
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0049 0.0137
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.022 0.114
Brugia malayi Heterochromatin protein 1 0.0068 0.0249 0.1293
Onchocerca volvulus 0.003 0.0068 0.263
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.022 0.5124
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0057 0.0199 0.4586
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Loa Loa (eye worm) thioredoxin reductase 0.0102 0.0413 0.1889
Brugia malayi Animal haem peroxidase family protein 0.0026 0.005 0.0241
Schistosoma mansoni smad1 5 8 and 0.0025 0.0047 0.0132
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2108 1 1
Leishmania major glycerol uptake protein, putative 0.0026 0.0049 0.0803
Brugia malayi neuroendocrine convertase 1 precursor 0.009 0.0354 0.185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0469 0.2169 0.6686
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0058
Leishmania major glycerol uptake protein, putative 0.0026 0.0049 0.0803
Leishmania major glycerol uptake protein, putative 0.0026 0.0049 0.0803
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0049 0.0137
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0049 0.0803
Onchocerca volvulus 0.0026 0.005 0.0152
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0057 0.0199 0.4586
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0049 0.0803
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.022 0.4395
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.022 0.5124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0438 0.1341
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Leishmania major cAMP-specific phosphodiesterase, putative 0.0057 0.0199 0.4586
Leishmania major hypothetical protein, conserved 0.0049 0.0159 0.3584
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0057 0.0199 0.06
Schistosoma mansoni chromobox protein 0.0068 0.0249 0.0755
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0199 0.4586
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0057 0.0199 0.06
Brugia malayi MH2 domain containing protein 0.0373 0.1708 0.9007
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0049 0.0137
Plasmodium falciparum thioredoxin reductase 0.0102 0.0413 1
Brugia malayi MH2 domain containing protein 0.0025 0.0047 0.0226
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.4796
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0057 0.0199 0.06
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0095 0.1958
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0017 0.0061
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1514 0.716 1
Brugia malayi TAR-binding protein 0.0066 0.0242 0.1256
Plasmodium vivax glutathione reductase, putative 0.0102 0.0413 1
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0049 0.0205
Schistosoma mansoni smad1 5 8 and 0.0025 0.0047 0.0132
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0205
Trypanosoma cruzi GUP1, putative 0.0026 0.0049 0.0803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0095 0.1958
Trypanosoma brucei unspecified product 0.0062 0.022 0.5124
Loa Loa (eye worm) hypothetical protein 0.0264 0.1187 0.5463
Trichomonas vaginalis porcupine, putative 0.0026 0.0049 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0199 0.4586
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0057 0.0199 0.4586
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0199 0.5332
Entamoeba histolytica hypothetical protein 0.0107 0.0438 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0233 0.1038 0.1335
Echinococcus granulosus neuroendocrine convertase 2 0.009 0.0354 0.1081
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0037 0.0101
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0087 0.164
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0129 0.2818
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.022 0.0203
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0057 0.0199 0.06
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.005 0.0152
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.0087 0.0254
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0049 0.0137
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0057 0.0199 0.1027
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0594 0.2766 0.2697
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0242 0.0734
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.005 0.021
Brugia malayi endoprotease bli-4 precursor 0.0143 0.0608 0.319
Brugia malayi polk-prov protein 0.0019 0.0017 0.0067
Treponema pallidum NADH oxidase 0.0035 0.0095 0.0046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0412 0.1896 0.5843
Loa Loa (eye worm) hypothetical protein 0.0057 0.0199 0.0898
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.003 0.008
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0209 0.5679
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0049 0.0137
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0469 0.2169 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0057 0.0199 0.06
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0047 0.0132
Brugia malayi glutathione reductase 0.0102 0.0413 0.2161
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0049 0.0137
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.006 0.021 0.0761
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.005 0.021
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0047 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0242 0.0734
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0469 0.2169 0.6686
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0209 0.4118
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0057 0.0199 0.06
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0438 0.1341
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Onchocerca volvulus Peroxidase homolog 0.0026 0.005 0.0152
Loa Loa (eye worm) PDE1B protein 0.0057 0.0199 0.0898
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.4586
Loa Loa (eye worm) hypothetical protein 0.0469 0.2169 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0049 0.0803
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0049 0.1161
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0209 0.4118
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0469 0.2169 0.6686
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0049 0.0803
Loa Loa (eye worm) hypothetical protein 0.009 0.0355 0.1622
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0152 0.3419
Leishmania major trypanothione reductase 0.0102 0.0413 1
Trypanosoma brucei unspecified product 0.0042 0.0129 0.2818
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.022 0.5124
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0057 0.0199 0.4586
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0121 0.2757
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0209 0.5679
Brugia malayi hypothetical protein 0.0026 0.005 0.0241
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0057 0.0199 0.4586
Echinococcus granulosus chromobox protein 1 0.0068 0.0249 0.0755
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0095 0.1958
Leishmania major glycerol uptake protein, putative 0.0026 0.0049 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0558
Schistosoma mansoni hypothetical protein 0.0036 0.0096 0.0282
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.005 0.024
Echinococcus multilocularis dna polymerase eta 0.009 0.0355 0.1084
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0057 0.0199 0.5332
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0095 0.0342
Brugia malayi hypothetical protein 0.0032 0.0076 0.038
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0057 0.0199 0.1027
Echinococcus multilocularis dna polymerase kappa 0.0062 0.022 0.0666
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0057 0.0199 0.5332
Giardia lamblia Hypothetical protein 0.0057 0.0199 0.0844
Echinococcus granulosus tar DNA binding protein 0.0066 0.0242 0.0734
Plasmodium vivax thioredoxin reductase, putative 0.0102 0.0413 1
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0199 0.4586
Loa Loa (eye worm) hypothetical protein 0.0052 0.0175 0.0786
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0222 0.0673
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0049 0.0137
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.022 0.0177
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0259 0.1162 0.1511
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0175 0.0786
Schistosoma mansoni chromobox protein 0.0068 0.0249 0.0755
Echinococcus multilocularis smad 0.0025 0.0047 0.0132
Schistosoma mansoni smad1 5 8 and 0.0025 0.0047 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Leishmania major hypothetical protein, conserved 0.0057 0.0199 0.4586
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Plasmodium falciparum thioredoxin reductase 0.0035 0.0095 0.1958
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0095 0.1899
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0242 0.0734
Echinococcus granulosus geminin 0.0694 0.3242 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0049 0.0389
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0047 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Brugia malayi MH1 domain containing protein 0.0025 0.0047 0.0226
Trypanosoma cruzi GUP1, putative 0.0026 0.0049 0.0803
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0095 0.0342
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0023 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0199 0.5332
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0057 0.0199 0.06
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Brugia malayi proprotein convertase 2 0.009 0.0354 0.185
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0057 0.0199 0.1027
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.005 0.021
Leishmania major hypothetical protein, conserved 0.0057 0.0199 0.4586
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0242 0.0734
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0121 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1514 0.716 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Loa Loa (eye worm) Smad1 0.0025 0.0047 0.0197
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.4796
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0242 0.0734
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0209 0.4118
Onchocerca volvulus Peroxidasin homolog 0.0026 0.005 0.0152
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0102 0.0413 0.0451
Schistosoma mansoni hypothetical protein 0.0028 0.0058 0.0164
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0096 0.0483
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.1187 0.3653
Loa Loa (eye worm) glutathione reductase 0.0102 0.0413 0.1889
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0211 0.5724
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0095 0.0279
Echinococcus multilocularis Smad4 0.0025 0.0047 0.0132
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0028 0.0058 0.0678
Echinococcus multilocularis thioredoxin glutathione reductase 0.0102 0.0413 0.1263
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0594 0.2766 1
Onchocerca volvulus Peroxidase homolog 0.0026 0.005 0.0152
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0209 0.4118
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0205
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0095 0.1899
Trichomonas vaginalis MYB, putative 0.006 0.0211 0.5724
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0558
Loa Loa (eye worm) hypothetical protein 0.0143 0.0608 0.2788
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0095 0.1958
Echinococcus granulosus bloom syndrome protein 0.0023 0.0037 0.0101
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0412 0.1896 0.5843
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0129 0.2818
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0107 0.2303
Loa Loa (eye worm) transcription factor SMAD2 0.0373 0.1708 0.787
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0049 0.0137
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0057 0.0199 0.1027
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0057 0.0199 0.4586
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0095 0.2271
Onchocerca volvulus 0.0026 0.005 0.0152
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0049 0.0137
Giardia lamblia DINP protein human, muc B family 0.0062 0.022 0.0943
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0087 0.034 0.1037
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.4586
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.022 0.0666
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0049 0.0803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Echinococcus multilocularis Furin 1 0.0034 0.0087 0.0254
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.022 0.6035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Brugia malayi Peroxidasin 0.0026 0.005 0.0241
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0047 0.0132
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0095 0.0361
Brugia malayi MBOAT family protein 0.0026 0.0049 0.0235
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.005 0.024
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Brugia malayi Thioredoxin reductase 0.0102 0.0413 0.2161
Brugia malayi MH1 domain containing protein 0.0025 0.0047 0.0226
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0047 0.0197
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0107 0.8083
Brugia malayi Animal haem peroxidase family protein 0.0026 0.005 0.0241
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0057 0.0199 0.06
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0159 0.3584
Echinococcus granulosus smad 0.0025 0.0047 0.0132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0175 0.09
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.4586
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0049 0.0803
Brugia malayi celfurPC protein 0.0115 0.0476 0.2492
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0057 0.0199 0.06
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0028 0.0058 0.0678
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0049 0.0205
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0087 0.164
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0095 0.2271
Brugia malayi Blistered cuticle protein 3 0.0026 0.005 0.0241
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0159 0.3584
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.022 0.5124
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0259 0.1162 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0129 0.2818
Onchocerca volvulus 0.0026 0.005 0.0152
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0014 0.0028
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0057 0.0199 0.06
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0049 0.0137
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Brugia malayi Hhat protein 0.0026 0.0049 0.0235
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0095 0.1958
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0047 0.0132
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Echinococcus granulosus furin 0.0143 0.0608 0.1864
Loa Loa (eye worm) hypothetical protein 0.0056 0.0193 0.0872
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0049 0.0137
Onchocerca volvulus Dual oxidase homolog 0.0026 0.005 0.0152
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0209 0.5679
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0095 0.1958
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.022 0.0203
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0049 0.0137
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0087 0.034 0.1037
Entamoeba histolytica hypothetical protein 0.0107 0.0438 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.034 1
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0049 0.0137
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0242 0.1256
Trichomonas vaginalis C-MYB, putative 0.0059 0.0209 0.5679
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.022 0.5124
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0057 0.0199 0.4586
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0143 0.0608 0.1864
Trypanosoma brucei DNA polymerase eta, putative 0.009 0.0355 0.8543
Loa Loa (eye worm) hhat protein 0.0026 0.0049 0.0205
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0095 0.1958
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0049 0.0137
Schistosoma mansoni Smad4 0.0025 0.0047 0.0132
Brugia malayi MBOAT family protein 0.0026 0.0049 0.0235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Trypanosoma brucei unspecified product 0.0042 0.0129 0.2818
Brugia malayi MBOAT family protein 0.0026 0.0049 0.0235
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.022 0.0666
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0087 0.164
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0259 0.1162 0.1511
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0057 0.0199 0.5332
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0199 0.4586
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0159 0.3833
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0049 0.0137
Echinococcus multilocularis peroxidasin 0.0026 0.005 0.0141
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2108 1 1
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0049 0.0235
Giardia lamblia High cysteine membrane protein Group 2 0.0053 0.0179 0.0753
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0049 0.0176
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0049 0.0205
Schistosoma mansoni hypothetical protein 0.0026 0.0049 0.0137
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0249 0.113
Loa Loa (eye worm) hypothetical protein 0.0238 0.1064 0.4894
Plasmodium falciparum phosphodiesterase delta, putative 0.0057 0.0199 0.4586
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0199 0.4586
Loa Loa (eye worm) endoprotease bli-4 0.0143 0.0608 0.2788
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0199 0.0718
Entamoeba histolytica hypothetical protein 0.0107 0.0438 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.022 0.0666
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.006 0.0211 0.5724
Brugia malayi Animal haem peroxidase family protein 0.0026 0.005 0.0241
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0049 0.0137
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0057 0.0199 0.5332
Brugia malayi Animal haem peroxidase family protein 0.0026 0.005 0.0241
Plasmodium vivax phosphodiesterase gamma, putative 0.0057 0.0199 0.4796
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0057 0.0199 0.1027
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0057 0.0199 0.4586
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0095 0.1958
Leishmania major DNA polymerase kappa, putative 0.0062 0.022 0.5124
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0057 0.0199 0.0898
Brugia malayi chromobox protein homolog 3 0.0038 0.0107 0.0542
Echinococcus multilocularis geminin 0.0694 0.3242 1
Trichomonas vaginalis C-MYB, putative 0.0059 0.0209 0.5679
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0049 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.022 0.5124
Trichomonas vaginalis hypothetical protein 0.0028 0.0058 0.0678
Schistosoma mansoni zinc finger protein 0.0026 0.0049 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0058 0.0678
Leishmania major DNA polymerase eta, putative 0.0047 0.0152 0.3419
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0059 0.0209 0.4118
Plasmodium falciparum glutathione reductase 0.0102 0.0413 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0412 0.1896 1
Leishmania major DNA polymerase eta, putative 0.009 0.0355 0.8543
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0469 0.2169 0.6686
Echinococcus granulosus peroxidasin 0.0026 0.005 0.0141
Brugia malayi hypothetical protein 0.0049 0.0159 0.0817
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0059 0.0209 0.5679
Brugia malayi Smad1 0.0025 0.0047 0.0226
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0057 0.0199 0.4586
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0095 0.0279

Activities

Activity type Activity value Assay description Source Reference
Delta TC (functional) = -14 % Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 50 mg/kg ChEMBL. 8632431
Delta TC (functional) = -14 % Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 50 mg/kg ChEMBL. 8632431
IC50 (binding) = 4.1 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431
IC50 (binding) = 4.1 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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