Detailed information for compound 266081

Basic information

Technical information
  • TDR Targets ID: 266081
  • Name: 2,4-dimethylpentan-3-yl N-[(3S)-5-methyl-1,2- dioxo-1-(thiophen-2-ylmethylamino)hexan-3-yl] carbamate
  • MW: 396.544 | Formula: C20H32N2O4S
  • H donors: 2 H acceptors: 3 LogP: 4.83 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C[C@@H](C(=O)C(=O)NCc1cccs1)NC(=O)OC(C(C)C)C(C)C)C
  • InChi: 1S/C20H32N2O4S/c1-12(2)10-16(22-20(25)26-18(13(3)4)14(5)6)17(23)19(24)21-11-15-8-7-9-27-15/h7-9,12-14,16,18H,10-11H2,1-6H3,(H,21,24)(H,22,25)/t16-/m0/s1
  • InChiKey: UZJJBVNFVOFOGM-INIZCTEOSA-N  


Substructure search Similarity search

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Synonyms

  • (1-isopropyl-2-methyl-propyl) N-[(1S)-3-methyl-1-[2-oxo-2-(2-thienylmethylamino)acetyl]butyl]carbamate
  • N-[(1S)-1-[1,2-dioxo-2-(2-thienylmethylamino)ethyl]-3-methylbutyl]carbamic acid (1-isopropyl-2-methylpropyl) ester
  • N-[(1S)-1-[2-keto-2-(2-thenylamino)acetyl]-3-methyl-butyl]carbamic acid (1-isopropyl-2-methyl-propyl) ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0198 0.0198
Echinococcus multilocularis mannose 6 phosphate isomerase 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.1512 0.1512
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.1512 0.1512
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1512 0.1512
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1512 0.1512
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0198 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0481 0.0481
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0198 0.0198
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1512 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.4097 0.4097
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.2293 0.2293
Plasmodium vivax vivapain-2 0.0027 0.1512 0.1512
Trypanosoma cruzi phosphomannose isomerase, putative 0.01 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0481 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.01 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.1512 0.1512
Onchocerca volvulus Cathepsin F homolog 0.0027 0.1512 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.3529 0.3529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0481 0.0481
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.3529 0.3529
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1512 0.1512
Loa Loa (eye worm) fibroinase 0.0027 0.1512 0.134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.3529 0.3529
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.01 1 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Trypanosoma cruzi phosphomannose isomerase, putative 0.01 1 1
Brugia malayi cathepsin L-like precursor 0.0018 0.0481 0.0481
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0046 0.3708 0.3708
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.3529 0.3529
Onchocerca volvulus 0.0027 0.1512 1
Onchocerca volvulus 0.0027 0.1512 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Loa Loa (eye worm) cysteine protease 0.0027 0.1512 0.134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.01 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0481 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Onchocerca volvulus 0.0027 0.1512 1
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Loa Loa (eye worm) hypothetical protein 0.0018 0.0481 0.0288
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.3529 0.3398
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1512 0.1512
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0198 0.0198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1512 0.1512
Onchocerca volvulus 0.0027 0.1512 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0481 0.0481
Loa Loa (eye worm) ctsf protein 0.0027 0.1512 0.134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.3529 0.3529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Echinococcus multilocularis GPCR, family 2 0.0016 0.0198 0.0198
Onchocerca volvulus 0.0027 0.1512 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.1512 0.134
Entamoeba histolytica phosphomannose isomerase, putative 0.01 1 1
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.01 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Plasmodium vivax vivapain-2 0.0027 0.1512 0.1512
Onchocerca volvulus 0.0027 0.1512 1
Leishmania major phosphomannose isomerase 0.01 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0481 0.0481
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.1512 0.1512
Brugia malayi Cathepsin L-like precursor 0.0018 0.0481 0.0481
Echinococcus granulosus GPCR family 2 0.0016 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0481 0.0288
Brugia malayi Cathepsin L-like precursor 0.0027 0.1512 0.1512
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1512 0.1512
Brugia malayi Cathepsin L-like precursor 0.0027 0.1512 0.1512
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1512 1
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.01 1 1
Trypanosoma brucei phosphomannose isomerase 0.01 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.1512 0.1512
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.4097 0.4097
Brugia malayi Cathepsin L-like precursor 0.0018 0.0481 0.0481
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Echinococcus multilocularis cysteine protease 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.3529 0.3529
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.3529 0.3529
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1512 1
Echinococcus granulosus cathepsin l1 0.0027 0.1512 0.1512
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.01 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.1512 0.1512
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.4097 0.3978
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1512 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.01 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1512 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Loa Loa (eye worm) hypothetical protein 0.0049 0.4097 0.3978
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Brugia malayi Cathepsin L-like precursor 0.0027 0.1512 0.1512
Schistosoma mansoni hypothetical protein 0.0016 0.0198 0.0198
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0054 0.4686 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.1512 0.134
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1512 0.1512
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.1512 0.134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0481 0.0481
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Entamoeba histolytica cysteine protease, putative 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Schistosoma mansoni hypothetical protein 0.0034 0.2293 0.2293
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0054 0.4686 0.5
Onchocerca volvulus 0.0027 0.1512 1
Schistosoma mansoni mannose-6-phosphate isomerase 0.01 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1512 0.1512
Toxoplasma gondii phosphomannose isomerase type I protein 0.01 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Echinococcus granulosus cathepsin l1 0.0018 0.0481 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1512 0.1512
Brugia malayi Cathepsin L-like precursor 0.0027 0.1512 0.1512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1512 0.1512
Echinococcus granulosus mannose 6 phosphate isomerase 0.01 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1512 0.1512
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0198 0.0198
Echinococcus multilocularis cysteine protease 0.0027 0.1512 0.1512
Loa Loa (eye worm) hypothetical protein 0.0034 0.2293 0.2137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1512 0.1512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.3529 0.3529

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 24 nM Concentration required to inhibit 50% of cysteine protease cathepsin K of human ChEMBL. 14736240
IC50 (binding) = 24 nM Concentration required to inhibit 50% of cysteine protease cathepsin K of human ChEMBL. 14736240

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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