Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.2046 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2046 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2046 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2046 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2046 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2046 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2046 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2046 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2046 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2046 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2046 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2046 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
HR (functional) | = 340 beats min-1 | Assessment of antihypertensive activity at 100 mg/kg administered perorally by measuring the heart rate in rats | ChEMBL. | 2918504 |
HR (functional) | = 350 beats min-1 | The antihypertensive activity of the compound was assessed by measuring the heart rate in rats when administered at 50 mg/kg | ChEMBL. | 2918504 |
MABP (functional) | = 70 mmHg | The antihypertensive activity of the compound was assessed by measuring the mean arterial blood pressure in rats when administered at 50 mg/kg | ChEMBL. | 2918504 |
MABP (functional) | = 112 mmHg | Assessment of antihypertensive activity at 100 mg/kg administered perorally by measuring mean arterial blood pressure (MABP) in rats | ChEMBL. | 2918504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.