Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.047 | 0.0286 | 0.0281 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0817 | 0.0983 | 0.0989 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0394 | 0.0135 | 0.0314 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0338 | 0.0022 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0963 | 0.1276 | 0.1287 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2315 | 0.399 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0338 | 0.0022 | 0.0012 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0771 | 0.0891 | 0.196 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0342 | 0.003 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.0364 | 0.036 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0781 | 0.091 | 0.0915 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.096 | 0.127 | 0.1281 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.1052 | 0.1455 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.0181 | 0.0173 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.158 | 0.2515 | 0.2546 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0781 | 0.091 | 0.0901 |
Echinococcus multilocularis | histone deacetylase 3 | 0.2315 | 0.399 | 0.4044 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.047 | 0.0286 | 0.0281 |
Echinococcus multilocularis | 0.0807 | 0.0963 | 0.0969 | |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.047 | 0.0286 | 0.0281 |
Brugia malayi | Hr1 repeat family protein | 0.047 | 0.0286 | 0.0281 |
Brugia malayi | Histone deacetylase 1 | 0.2315 | 0.399 | 0.4044 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0807 | 0.0963 | 0.0969 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.158 | 0.2515 | 0.2546 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.158 | 0.2515 | 0.2546 |
Trypanosoma brucei | histone deacetylase 1 | 0.2315 | 0.399 | 1 |
Toxoplasma gondii | phosphatidylinositol 4-kinase | 0.0572 | 0.0491 | 0.1209 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1052 | 0.1455 | 0.1447 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.047 | 0.0286 | 0.0281 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0338 | 0.0022 | 0.0012 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.047 | 0.0286 | 0.0281 |
Echinococcus granulosus | NDR protein kinase | 0.047 | 0.0286 | 0.0281 |
Onchocerca volvulus | 0.0674 | 0.0697 | 0.1126 | |
Plasmodium vivax | histone deacetylase 1, putative | 0.2315 | 0.399 | 1 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0906 | 0.1162 | 0.117 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0817 | 0.0983 | 0.0989 |
Plasmodium vivax | histone deacetylase, putative | 0.1206 | 0.1763 | 0.2733 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0832 | 0.1014 | 0.1021 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.0697 | 0.0698 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.2315 | 0.399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0906 | 0.1162 | 0.117 |
Trypanosoma brucei | histone deacetylase, putative | 0.1206 | 0.1763 | 0.4224 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.047 | 0.0286 | 0.0281 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1052 | 0.1455 | 0.1468 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0566 | 0.048 | 0.0477 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.0697 | 0.0698 |
Echinococcus multilocularis | Phosphatidylinositol 4 kinase type 2 beta | 0.0338 | 0.0022 | 0.0012 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0781 | 0.091 | 0.0915 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0679 | 0.0706 | 0.1749 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0535 | 0.0418 | 0.0415 |
Brugia malayi | Protein kinase domain containing protein | 0.047 | 0.0286 | 0.0281 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0906 | 0.1162 | 0.117 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 0.091 | 0.0915 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0963 | 0.1276 | 0.1287 |
Plasmodium vivax | phosphatidylinositol 4-kinase, putative | 0.0807 | 0.0963 | 0.0122 |
Brugia malayi | Protein kinase domain containing protein | 0.047 | 0.0286 | 0.0281 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0781 | 0.091 | 0.0915 |
Loa Loa (eye worm) | histone deacetylase | 0.1206 | 0.1763 | 0.1782 |
Schistosoma mansoni | serine/threonine protein kinase | 0.047 | 0.0286 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0906 | 0.1162 | 0.117 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Schistosoma mansoni | histone deacetylase hda2 | 0.1297 | 0.1947 | 0.1939 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0781 | 0.091 | 0.0915 |
Plasmodium vivax | histone deacetylase 2, putative | 0.1206 | 0.1763 | 0.2733 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.5234 | 0.985 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0832 | 0.1014 | 0.1021 |
Echinococcus granulosus | histone deacetylase 6 | 0.1206 | 0.1763 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.0697 | 0.0698 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2315 | 0.399 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0807 | 0.0963 | 0.2149 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0832 | 0.1014 | 0.1021 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1795 | 0.2947 | 0.294 |
Schistosoma mansoni | serine/threonine protein kinase | 0.047 | 0.0286 | 0.0276 |
Schistosoma mansoni | atypical protein kinase C | 0.0802 | 0.0953 | 0.0944 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.047 | 0.0286 | 0.0281 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Brugia malayi | hypothetical protein | 0.0906 | 0.1162 | 0.117 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0906 | 0.1162 | 0.117 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0788 | 0.0926 | 0.2302 |
Echinococcus granulosus | histone deacetylase 3 | 0.2315 | 0.399 | 0.4044 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0342 | 0.003 | 0.002 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0394 | 0.0135 | 0.0127 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Leishmania major | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Brugia malayi | protein kinase C3,putative | 0.0342 | 0.003 | 0.0021 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0342 | 0.003 | 0.0021 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0788 | 0.0926 | 0.0917 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Echinococcus multilocularis | protein kinase c iota type | 0.0802 | 0.0953 | 0.0958 |
Trypanosoma brucei | histone deacetylase 3 | 0.1206 | 0.1763 | 0.4224 |
Brugia malayi | protein kinase C II. | 0.0832 | 0.1014 | 0.1021 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0788 | 0.0926 | 0.2302 |
Entamoeba histolytica | protein kinase, putative | 0.047 | 0.0286 | 0.0694 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0417 | 0.018 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.158 | 0.2515 | 0.2546 |
Brugia malayi | LBP/BPI | 0.0674 | 0.0697 | 0.0698 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0781 | 0.091 | 0.0915 |
Echinococcus granulosus | histone deacetylase 7 | 0.1206 | 0.1763 | 0.1782 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.158 | 0.2515 | 0.2546 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0771 | 0.0891 | 0.2213 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.2315 | 0.399 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0771 | 0.0891 | 0.196 |
Leishmania major | histone deacetylase, putative | 0.1206 | 0.1763 | 0.2643 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0781 | 0.091 | 0.0901 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.047 | 0.0286 | 0.0281 |
Echinococcus granulosus | histone deacetylase 8 | 0.0788 | 0.0926 | 0.0931 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0788 | 0.0926 | 0.1502 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0781 | 0.091 | 0.0915 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.0071 | 0.0063 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.047 | 0.0286 | 0.0281 |
Echinococcus granulosus | Phosphatidylinositol 4 kinase type 2 beta | 0.0338 | 0.0022 | 0.0012 |
Echinococcus granulosus | histone deacetylase | 0.1206 | 0.1763 | 0.1782 |
Echinococcus granulosus | protein kinase C gamma type | 0.1463 | 0.2281 | 0.2308 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.047 | 0.0286 | 0.0281 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Schistosoma mansoni | unc-13 (munc13) | 0.0363 | 0.0071 | 0.0062 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1206 | 0.1763 | 0.4224 |
Schistosoma mansoni | protein kinase C | 0.0363 | 0.0071 | 0.0062 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.063 | 0.0608 | 0.1226 |
Loa Loa (eye worm) | hypothetical protein | 0.0906 | 0.1162 | 0.117 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.093 | 0.121 | 0.122 |
Brugia malayi | Protein kinase domain containing protein | 0.5234 | 0.985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5224 | 0.983 | 0.9979 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0536 | 0.0419 | 0.1027 |
Loa Loa (eye worm) | calcium channel | 0.0781 | 0.091 | 0.0915 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0535 | 0.0418 | 0.0415 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.047 | 0.0286 | 0.0281 |
Entamoeba histolytica | hypothetical protein | 0.0679 | 0.0706 | 0.1749 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.047 | 0.0286 | 0.0392 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.2315 | 0.399 | 0.4044 |
Echinococcus granulosus | unc 13 munc13 | 0.0363 | 0.0071 | 0.0063 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1463 | 0.2281 | 0.2308 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.093 | 0.121 | 0.122 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0363 | 0.0071 | 0.0063 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0807 | 0.0963 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0788 | 0.0926 | 0.0931 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.046 | 0.0266 | 0.0339 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0538 | 0.0423 | 0.1061 |
Onchocerca volvulus | 0.0906 | 0.1162 | 0.1888 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0906 | 0.1162 | 0.117 |
Brugia malayi | C1-like domain containing protein | 0.0342 | 0.003 | 0.0021 |
Echinococcus granulosus | histone deacetylase 6 | 0.1206 | 0.1763 | 0.1782 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0781 | 0.091 | 0.0915 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1206 | 0.1763 | 0.1782 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0977 | 0.1305 | 0.3254 |
Onchocerca volvulus | 0.0363 | 0.0071 | 0.0101 | |
Leishmania major | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Loa Loa (eye worm) | phosphatidylinositol kinase | 0.0338 | 0.0022 | 0.0012 |
Echinococcus granulosus | histone deacetylase 6 | 0.1297 | 0.1947 | 0.1968 |
Plasmodium falciparum | histone deacetylase, putative | 0.1206 | 0.1763 | 0.2643 |
Loa Loa (eye worm) | hypothetical protein | 0.093 | 0.121 | 0.122 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0771 | 0.0891 | 0.196 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0781 | 0.091 | 0.0915 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1795 | 0.2947 | 0.294 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.047 | 0.0286 | 0.0281 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0874 | 0.1098 | 0.2735 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.5234 | 0.985 | 1 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0771 | 0.0891 | 0.196 |
Echinococcus multilocularis | Phosphatidylinositol 4 kinase type 2 beta | 0.0338 | 0.0022 | 0.0012 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0674 | 0.0697 | 0.1457 |
Giardia lamblia | Phosphatidylinositol 4-kinase | 0.0807 | 0.0963 | 0.2415 |
Entamoeba histolytica | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Trypanosoma brucei | histone deacetylase 2 | 0.0788 | 0.0926 | 0.2052 |
Brugia malayi | hypothetical protein | 0.0906 | 0.1162 | 0.117 |
Echinococcus granulosus | histone deacetylase 1 | 0.2315 | 0.399 | 0.4044 |
Onchocerca volvulus | 0.0906 | 0.1162 | 0.1888 | |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0443 | 0.0233 | 0.0562 |
Echinococcus granulosus | phosphatidylinositol 4 kinase beta | 0.0807 | 0.0963 | 0.0969 |
Brugia malayi | histone deacetylase 11 | 0.0788 | 0.0926 | 0.0931 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase, putative | 0.0807 | 0.0963 | 0.2149 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase, putative | 0.0807 | 0.0963 | 0.2149 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0342 | 0.003 | 0.0021 |
Schistosoma mansoni | voltage-gated cation channel | 0.0781 | 0.091 | 0.0901 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.093 | 0.121 | 0.1201 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Echinococcus multilocularis | histone deacetylase | 0.1206 | 0.1763 | 0.1782 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0807 | 0.0963 | 0.0954 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1795 | 0.2947 | 0.2985 |
Schistosoma mansoni | protein kinase C mu | 0.0342 | 0.003 | 0.002 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.047 | 0.0286 | 0.0281 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0342 | 0.003 | 0.0021 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.047 | 0.0286 | 0.0281 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0338 | 0.0022 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.0697 | 0.0698 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0788 | 0.0926 | 0.0917 |
Schistosoma mansoni | histone deacetylase | 0.2315 | 0.399 | 0.3984 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0832 | 0.1014 | 0.1005 |
Loa Loa (eye worm) | hypothetical protein | 0.3702 | 0.6775 | 0.6875 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0342 | 0.003 | 0.0021 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0781 | 0.091 | 0.0915 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0788 | 0.0926 | 0.0931 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0963 | 0.1276 | 0.1287 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.1004 | 0.1358 | 0.137 |
Brugia malayi | Protein kinase domain containing protein | 0.0342 | 0.003 | 0.0021 |
Brugia malayi | Histone deacetylase family protein | 0.1206 | 0.1763 | 0.1782 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.093 | 0.121 | 0.122 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1206 | 0.1763 | 0.4224 |
Loa Loa (eye worm) | hypothetical protein | 0.0338 | 0.0022 | 0.0012 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.2315 | 0.399 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0342 | 0.003 | 0.002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.047 | 0.0286 | 0.0276 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.2315 | 0.399 | 0.4044 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0781 | 0.091 | 0.0915 |
Schistosoma mansoni | unc-13 (munc13) | 0.0363 | 0.0071 | 0.0062 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.1206 | 0.1763 | 0.4406 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0363 | 0.0071 | 0.0063 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0906 | 0.1162 | 0.117 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1297 | 0.1947 | 0.1968 |
Onchocerca volvulus | 0.0338 | 0.0022 | 0.0019 | |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.2315 | 0.399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.337 | 0.6109 | 0.6197 |
Schistosoma mansoni | phosphatidylinositol 4-kinase type-II | 0.0338 | 0.0022 | 0.0012 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.5234 | 0.985 | 1 |
Giardia lamblia | Histone deacetylase | 0.2315 | 0.399 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.1206 | 0.1763 | 0.2643 |
Loa Loa (eye worm) | hypothetical protein | 0.337 | 0.6109 | 0.6197 |
Brugia malayi | Protein kinase domain containing protein | 0.047 | 0.0286 | 0.0281 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1206 | 0.1763 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.5224 | 0.983 | 0.9979 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0906 | 0.1162 | 0.117 |
Onchocerca volvulus | 0.158 | 0.2515 | 0.4108 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.047 | 0.0286 | 0.0276 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0788 | 0.0926 | 0.2052 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0781 | 0.091 | 0.0915 |
Trypanosoma brucei | histone deacetylase 4 | 0.1206 | 0.1763 | 0.4224 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.2315 | 0.399 | 0.4044 |
Entamoeba histolytica | protein kinase, putative | 0.047 | 0.0286 | 0.0694 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.047 | 0.0286 | 0.0281 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.047 | 0.0286 | 0.0281 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.047 | 0.0286 | 0.0281 |
Echinococcus granulosus | Phosphatidylinositol 4 kinase type 2 beta | 0.0338 | 0.0022 | 0.0012 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0906 | 0.1162 | 0.117 |
Echinococcus multilocularis | histone deacetylase 1 | 0.2315 | 0.399 | 0.4044 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1206 | 0.1763 | 0.1755 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1206 | 0.1763 | 0.4224 |
Entamoeba histolytica | protein kinase, putative | 0.047 | 0.0286 | 0.0694 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.1795 | 0.2947 | 0.2985 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.063 | 0.0608 | 0.1226 |
Onchocerca volvulus | 0.0338 | 0.0022 | 0.0019 | |
Brugia malayi | Protein kinase c protein 2 | 0.1336 | 0.2025 | 0.2047 |
Trichomonas vaginalis | histone deacetylase, putative | 0.2315 | 0.399 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.047 | 0.0286 | 0.0281 |
Echinococcus multilocularis | histone deacetylase 7 | 0.1206 | 0.1763 | 0.1782 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0417 | 0.018 | 0.0173 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.1206 | 0.1763 | 0.1782 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1206 | 0.1763 | 0.1755 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0425 | 0.0197 | 0.0187 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0963 | 0.1276 | 0.1287 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0771 | 0.0891 | 0.196 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0394 | 0.0135 | 0.0314 |
Echinococcus granulosus | protein kinase c iota type | 0.0802 | 0.0953 | 0.0958 |
Onchocerca volvulus | 0.337 | 0.6109 | 1 | |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.093 | 0.121 | 0.122 |
Leishmania major | histone deacetylase, putative | 0.1206 | 0.1763 | 0.2643 |
Toxoplasma gondii | AGC kinase | 0.047 | 0.0286 | 0.0694 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0817 | 0.0983 | 0.0989 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0771 | 0.0891 | 0.0895 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.2315 | 0.399 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.337 | 0.6109 | 0.6197 |
Entamoeba histolytica | protein kinase, putative | 0.047 | 0.0286 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.384 | 0.7051 | 0.7156 |
Toxoplasma gondii | 1-phosphatidylinositol 4-kinase | 0.0572 | 0.0491 | 0.1209 |
Brugia malayi | hypothetical protein | 0.0674 | 0.0697 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.1295 | 0.1943 | 0.1964 |
Schistosoma mansoni | serine/threonine kinase | 0.047 | 0.0286 | 0.0276 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0788 | 0.0926 | 0.2052 |
Loa Loa (eye worm) | hypothetical protein | 0.2315 | 0.399 | 0.4044 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0817 | 0.0983 | 0.0989 |
Schistosoma mansoni | histone deacetylase | 0.2315 | 0.399 | 0.3984 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.0418 | 0.0415 |
Brugia malayi | Histone deacetylase family protein | 0.1206 | 0.1763 | 0.1782 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0788 | 0.0926 | 0.0931 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.093 | 0.121 | 0.3033 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0417 | 0.018 | 0.017 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Trichomonas vaginalis | AGC family protein kinase | 0.047 | 0.0286 | 0.0392 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0363 | 0.0071 | 0.0063 |
Plasmodium falciparum | histone deacetylase 1 | 0.2315 | 0.399 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.2315 | 0.399 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ILS (functional) | = 70 % | Antitumor activity against L1210 Leukemia in mice at a dose of 30 mg/kg expressed as percent of increase in life span after day 60s was determined. | ChEMBL. | 3820230 |
ILS (functional) | = 110 % | Antitumor activity against L1210 Leukemia in mice at a dose of 100 mg/kg expressed as percent of increase in life span after day 60s was determined. | ChEMBL. | 3820230 |
ILS (functional) | = 190 % | Antitumor activity against L1210 Leukemia in mice at a dose of 200 mg/kg expressed as percent of increase in life span after day 60s was determined. | ChEMBL. | 3820230 |
LD50 (ADMET) | = 260 mg kg-1 | Antitumor activity against L1210 Leukemia in mice expressed as 50% lethal dose was determined at 200 mg/kg | ChEMBL. | 3820230 |
MED (functional) | = 0.059 mM kg-1 | Antitumor activity against L1210 Leukemia in mice at a dose of 30 mg/kg was determined. | ChEMBL. | 3820230 |
MED (functional) | = 0.2 mM kg-1 | Antitumor activity against L1210 Leukemia in mice at a dose of 100 mg/kg was determined. | ChEMBL. | 3820230 |
MED (functional) | = 0.4 mM kg-1 | Antitumor activity against L1210 Leukemia in mice at a dose of 200 mg/kg was determined. | ChEMBL. | 3820230 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.