Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.2072 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2072 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2072 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2072 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2072 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2072 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2072 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.2072 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2072 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.2072 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2072 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2072 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CCIC50 (ADMET) | = 17 uM | Cytotoxicity was determined against uninfected MT-4 cells | ChEMBL. | 9484509 |
EC50 (functional) | = 0.29 uM | Effective concentration required for the inhibition of HIV-1 IIIB in MT-4 cells | ChEMBL. | 9484509 |
Inhibition (binding) | = 50 % | Inhibition of purified recombinant HIV-1 protease at 0.5 nm using a fluorogenic substrate | ChEMBL. | 9484509 |
Inhibition (binding) | = 50 % | Inhibition of purified recombinant HIV-1 protease at 0.5 nm using a fluorogenic substrate | ChEMBL. | 9484509 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.