Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Type-1 angiotensin II receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.78 mg kg-1 | Compound was evaluated by intravenous administration to conscious rats for inhibition of pressor response induced by infusion of AII (n=3-10) | ChEMBL. | 8487261 |
IC50 (binding) | = 0.025 uM | Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1 | ChEMBL. | 8487261 |
IC50 (binding) | = 0.025 uM | Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1 | ChEMBL. | 8487261 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.