Detailed information for compound 266502

Basic information

Technical information
  • TDR Targets ID: 266502
  • Name: 6,6,9-trimethyl-3-pentyl-7,8,9,10-tetrahydrob enzo[c]chromen-1-ol
  • MW: 314.462 | Formula: C21H30O2
  • H donors: 1 H acceptors: 1 LogP: 5.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCc1cc(O)c2c(c1)OC(C1=C2CC(C)CC1)(C)C
  • InChi: 1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h12-14,22H,5-11H2,1-4H3
  • InChiKey: NEBZNJDFIPBXCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,6,9-trimethyl-3-pentyl-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-1-ol
  • 3-amyl-6,6,9-trimethyl-7,8,9,10-tetrahydrobenzo[c]chromen-1-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0024 0.0016
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0252 0.0651 0.1799
Brugia malayi proteasome subunit beta type 1 0.0996 0.2792 0.2791
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Echinococcus granulosus hypothetical protein 0.0212 0.0537 0.0537
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0115 0.0256 0.0255
Echinococcus multilocularis voltage gated potassium channel 0.0212 0.0537 0.0537
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni importin beta-1 0.0032 0.0018 0.0018
Schistosoma mansoni myosin xvIII 0.004 0.004 0.004
Echinococcus granulosus g protein coupled receptor 0.004 0.004 0.004
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Echinococcus multilocularis proteasome subunit beta type 7 0.0252 0.0651 0.0651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Schistosoma mansoni alpha glucosidase 0.0037 0.0034 0.0034
Leishmania major proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0212 0.0537 0.0537
Echinococcus multilocularis orexin receptor type 2 0.004 0.004 0.004
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0212 0.0537 0.0537
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0252 0.0651 0.176
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0996 0.2792 0.7723
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0223 0.0223
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0617 0.1702 0.4707
Leishmania major hypothetical protein, conserved 0.0066 0.0117 0.0323
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.004 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.004 0.004
Echinococcus multilocularis tar DNA binding protein 0.0276 0.0719 0.0719
Brugia malayi CHE-14 protein 0.0044 0.0052 0.0051
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus G protein coupled receptor 139 0.004 0.004 0.004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0064
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.004 0.0039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0092 0.0092
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1282 0.3614 1
Onchocerca volvulus 0.0066 0.0117 0.094
Mycobacterium ulcerans proteasome PrcA 0.0252 0.0651 0.1798
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Giardia lamblia Proteasome subunit beta type 2 0.0617 0.1702 0.4707
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0026 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis proteasome subunit alpha type 2 0.0252 0.0651 0.0651
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.041 0.041
Echinococcus multilocularis somatostatin receptor 0.004 0.004 0.004
Loa Loa (eye worm) STAT protein 0.0174 0.0427 0.0426
Loa Loa (eye worm) hypothetical protein 0.0578 0.159 0.159
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0034 0.0092
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0252 0.0651 0.1799
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.3502 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Brugia malayi Proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0212 0.0537 0.0537
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0002 0.0003
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Leishmania major proteasome alpha 3 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0057 0.009 0.0089
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus granulosus neuropeptides capa receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0252 0.0651 0.18
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0066 0.0117 0.032
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0252 0.0651 0.176
Echinococcus granulosus importin subunit beta 1 0.0032 0.0018 0.0018
Onchocerca volvulus 0.0026 0.0002 0.0006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.004 0.0039
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.004 0.004
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0212 0.0537 0.0537
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0617 0.1702 0.4707
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0252 0.0651 0.0651
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.006 0.0099 0.5
Echinococcus granulosus expressed conserved protein 0.0095 0.0201 0.0201
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0252 0.0651 0.0651
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0212 0.0537 0.1483
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.004 0.0318
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.004 0.004
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0252 0.0651 0.176
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0252 0.0651 0.18
Trichomonas vaginalis set domain proteins, putative 0.0456 0.1239 0.3426
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.004 0.004
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0252 0.0651 0.0651
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis conserved hypothetical protein 0.0212 0.0537 0.0537
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.009 0.0247
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.004 0.004
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi ORL1-like opioid receptor 0.004 0.004 0.0039
Brugia malayi cation channel family protein 0.0212 0.0537 0.0536
Brugia malayi beta-lactamase family protein 0.0066 0.0117 0.0116
Onchocerca volvulus 0.004 0.004 0.0318
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0026 0.0025
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0252 0.0651 0.18
Echinococcus granulosus voltage gated hydrogen channel 1 0.0212 0.0537 0.0537
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0212 0.0537 0.1483
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0252 0.0651 0.18
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Echinococcus multilocularis conserved hypothetical protein 0.0728 0.2021 0.2021
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1282 0.3614 1
Echinococcus granulosus subfamily T1A non peptidase ue 0.0252 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Echinococcus granulosus transient receptor potential gamma protein 0.0212 0.0537 0.0537
Plasmodium vivax proteasome subunit beta type-6, putative 0.0252 0.0651 0.1799
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0252 0.0651 0.18
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0252 0.0651 0.0651
Trichomonas vaginalis rotamase, putative 0.0035 0.0026 0.0071
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.3502 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Mycobacterium tuberculosis Probable lipase LipE 0.0066 0.0117 0.032
Echinococcus granulosus g protein coupled receptor 0.004 0.004 0.004
Plasmodium vivax proteasome subunit beta type-2, putative 0.0617 0.1702 0.4707
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.0256 0.0255
Echinococcus multilocularis expressed protein 0.0387 0.1041 0.1041
Leishmania major hypothetical protein, conserved 0.0212 0.0537 0.1483
Echinococcus granulosus proteasome subunit beta type 7 0.0252 0.0651 0.0651
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0252 0.0651 0.176
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.003
Echinococcus multilocularis expressed protein 0.0035 0.0026 0.0026
Onchocerca volvulus 0.004 0.004 0.0318
Trypanosoma cruzi 20S proteasome subunit 0.0617 0.1702 0.4707
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0212 0.0537 0.0536
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0617 0.1702 0.4707
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) ryanodine receptor 0.0212 0.0537 0.0536
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0252 0.0651 0.1799
Echinococcus granulosus g-protein coupled receptor 0.004 0.004 0.004
Onchocerca volvulus 0.005 0.007 0.0555
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1282 0.3614 0.3614
Toxoplasma gondii proteasome subunit alpha1, putative 0.0252 0.0651 0.1799
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0212 0.0537 0.4328
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Brugia malayi proteasome subunit alpha type 1 0.0252 0.0651 0.065
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0252 0.0651 0.0651
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0252 0.0651 0.065
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0031 0.0031
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0212 0.0537 0.0537
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Brugia malayi putative neuropeptide receptor 0.004 0.004 0.0039
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.004 0.004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0052 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0002 0.0001
Schistosoma mansoni histamine h1 receptor 0.004 0.004 0.004
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0212 0.0537 0.0536
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0252 0.0651 0.1799
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.0092
Schistosoma mansoni biogenic amine receptor 0.004 0.004 0.004
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis expressed conserved protein 0.0095 0.0201 0.0201
Echinococcus granulosus proteasome subunit alpha type 2 0.0252 0.0651 0.0651
Brugia malayi Muscleblind-like protein 0.0165 0.0401 0.04
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0252 0.0651 0.18
Echinococcus granulosus expressed protein 0.0387 0.1041 0.1041
Echinococcus multilocularis voltage dependent calcium channel 0.3502 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis g protein coupled receptor 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni hypothetical protein 0.0212 0.0537 0.0537
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0617 0.1702 0.1702
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.041 0.0409
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus granulosus sodium channel protein 0.0212 0.0537 0.0537
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Echinococcus granulosus neuropeptides capa receptor 0.004 0.004 0.004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0066 0.0117 0.0116
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0212 0.0537 0.0536
Plasmodium falciparum proteasome subunit beta type-5 0.1282 0.3614 1
Echinococcus multilocularis neuropeptide receptor 0.004 0.004 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Mycobacterium ulcerans esterase/lipase LipP 0.0066 0.0117 0.032
Plasmodium vivax proteasome subunit beta type-7, putative 0.0252 0.0651 0.1799
Toxoplasma gondii transporter, cation channel family protein 0.0212 0.0537 0.1483
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0034 0.0092
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.004 0.004
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0252 0.0651 0.0651
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.004 0.004
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0252 0.0651 0.1799
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.0693 0.0692
Loa Loa (eye worm) voltage-gated potassium channel 0.0212 0.0537 0.0536
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.004 0.0039
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Echinococcus granulosus beta LACTamase domain containing family member 0.0066 0.0117 0.0117
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Brugia malayi proteasome subunit beta type 3 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0092 0.0092
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1282 0.3614 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.004 0.004
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0212 0.0537 0.0537
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0212 0.0537 0.0536
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.004 0.004
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.004 0.0039
Schistosoma mansoni voltage-gated ion channel 0.0212 0.0537 0.0537
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0092 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0002 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.004 0.004
Schistosoma mansoni alpha-glucosidase 0.0145 0.0343 0.0343
Loa Loa (eye worm) PAS-3 protein 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) voltage-gated calcium channel 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Leishmania major hypothetical protein, conserved 0.0057 0.009 0.0248
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.006 0.0099 0.027
Echinococcus granulosus tar DNA binding protein 0.0276 0.0719 0.0719
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0001
Echinococcus granulosus neuropeptide receptor 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Trichomonas vaginalis penicillin-binding protein, putative 0.0066 0.0117 0.0323
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0617 0.1702 0.1702
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0163 0.0396 0.0395
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0344 0.0344
Leishmania major proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Brugia malayi voltage-dependent calcium channel 0.0212 0.0537 0.0536
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0252 0.0651 0.065
Echinococcus granulosus two pore calcium channel protein 2 0.0212 0.0537 0.0537
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0212 0.0537 0.1483
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus granulosus two pore calcium channel protein 1 0.0212 0.0537 0.0537
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.004 0.004
Brugia malayi G protein-coupled receptor 0.004 0.004 0.0039
Schistosoma mansoni alpha-glucosidase 0.0145 0.0343 0.0343
Giardia lamblia 20S proteasome alpha subunit 5 0.0252 0.0651 0.1799
Echinococcus granulosus neuropeptide receptor A26 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Echinococcus multilocularis two pore calcium channel protein 1 0.0212 0.0537 0.0537
Plasmodium falciparum importin beta, putative 0.0032 0.0018 0.0047
Brugia malayi hypothetical protein 0.0244 0.0628 0.0627
Brugia malayi RE15519p 0.004 0.004 0.0039
Schistosoma mansoni hypothetical protein 0.0075 0.0141 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Brugia malayi sulfakinin receptor protein 0.004 0.004 0.0039
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0034 0.0033
Mycobacterium leprae Probable lipase LipE 0.0066 0.0117 0.032
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.004 0.004
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0252 0.0651 0.18
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0018 0.0047
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0212 0.0537 0.0537
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.004 0.004
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.004 0.004
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0252 0.0651 0.18
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.009 0.0248
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0252 0.0651 0.0651
Brugia malayi 20S proteasome alpha5 subunit 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0083 0.0167 0.0167
Toxoplasma gondii ABC1 family protein 0.0066 0.0117 0.0322
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0031 0.003
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0252 0.0651 0.0651
Brugia malayi beta-lactamase family protein 0.0066 0.0117 0.0116
Brugia malayi proteasome subunit alpha type 3 0.0252 0.0651 0.065
Echinococcus granulosus sex peptide receptor 0.004 0.004 0.004
Leishmania major proteasome alpha 2 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Schistosoma mansoni jumonji domain containing protein 0.0067 0.012 0.012
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.004 0.0039
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0252 0.0651 0.176
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.006 0.0099 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Giardia lamblia Deoxynucleoside kinase 0.0723 0.2006 0.5548
Plasmodium vivax proteasome subunit beta type-3, putative 0.0252 0.0651 0.1799
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0212 0.0537 0.0536
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0628 0.0628
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus fmrfamide receptor 0.004 0.004 0.004
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis PHD finger protein rhinoceros 0.0026 0.0001 0.0001
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) transcription factor SMAD2 0.0227 0.0579 0.0578
Brugia malayi G-protein coupled receptor 0.004 0.004 0.0039
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.004 0.004
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0996 0.2792 0.7723
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0578 0.159 0.4399
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0895 0.25 0.25
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0212 0.0537 0.0537
Echinococcus multilocularis sodium leak channel non selective protein 0.0212 0.0537 0.0537
Onchocerca volvulus 0.0212 0.0537 0.4328
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.004 0.004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0028 0.0028
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.006 0.0099 0.5
Plasmodium vivax importin-beta 2, putative 0.0032 0.0018 0.0047
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0212 0.0537 0.0537
Trichomonas vaginalis D-aminoacylase, putative 0.0066 0.0117 0.0323
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0252 0.0651 0.0651
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Onchocerca volvulus 0.0456 0.1239 1
Echinococcus granulosus voltage gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis allatostatin A receptor 0.004 0.004 0.004
Toxoplasma gondii peptidase, T1 family protein 0.0252 0.0651 0.1799
Brugia malayi proteasome subunit alpha type 4 0.0252 0.0651 0.065
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.004 0.0039
Giardia lamblia Proteasome subunit beta type 1 0.0996 0.2792 0.7723
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0996 0.2792 0.7723
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.004 0.004
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis serotonin receptor 0.004 0.004 0.004
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0212 0.0537 0.0537
Brugia malayi olfactory channel protein osm-9 0.0212 0.0537 0.0536
Echinococcus multilocularis g protein coupled receptor 0.004 0.004 0.004
Brugia malayi ion channel NompC 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0102 0.0219 0.0218
Echinococcus granulosus allatostatin A receptor 0.004 0.004 0.004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0424 0.1146 0.3167
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus voltage dependent calcium channel 0.3502 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0212 0.0537 0.0536
Echinococcus multilocularis neuropeptide s receptor 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Brugia malayi MH2 domain containing protein 0.0227 0.0579 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0052 0.0142
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0141 0.0141
Loa Loa (eye worm) proteasome subunit beta type 2 0.0617 0.1702 0.1701
Brugia malayi jmjC domain containing protein 0.0085 0.017 0.0169
Echinococcus multilocularis transient receptor potential gamma protein 0.0212 0.0537 0.0537
Toxoplasma gondii hypothetical protein 0.0212 0.0537 0.1483
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Brugia malayi larval opioid receptor 0.004 0.004 0.0039
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.004 0.004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.004 0.0039
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0212 0.0537 0.1442
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) calcium channel 0.3502 1 1
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus multilocularis protein patched 0.0044 0.0052 0.0052
Onchocerca volvulus 0.004 0.004 0.0318
Schistosoma mansoni biogenic amine receptor 0.004 0.004 0.004
Echinococcus granulosus voltage dependent calcium channel 0.0212 0.0537 0.0537
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0252 0.0651 0.176
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.3502 1 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0034 0.0092
Giardia lamblia 20S proteasome alpha subunit 2 0.0252 0.0651 0.1799
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0252 0.0651 0.1799
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0252 0.0651 0.1799
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0141 0.0141
Echinococcus granulosus voltage gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.004 0.004
Plasmodium vivax proteasome subunit beta type-4, putative 0.0252 0.0651 0.1799
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0252 0.0651 0.1799
Brugia malayi hypothetical protein 0.0037 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi Cyclic-nucleotide gated cation channel 0.0212 0.0537 0.0536
Loa Loa (eye worm) voltage-gated potassium channel 0.0212 0.0537 0.0536
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Brugia malayi Pre-SET motif family protein 0.0401 0.1079 0.1079
Echinococcus multilocularis hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Plasmodium vivax proteasome subunit beta type-1, putative 0.0996 0.2792 0.7723
Toxoplasma gondii proteasome subunit beta type, putative 0.1282 0.3614 1
Brugia malayi Dopamine receptor protein 2 0.004 0.004 0.0039
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus multilocularis transfer RNA-Gly 0.0212 0.0537 0.0537
Brugia malayi Serotonin receptor 0.0525 0.1437 0.1436
Onchocerca volvulus 0.0066 0.0117 0.094
Brugia malayi cation channel family protein 0.0212 0.0537 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Leishmania major proteasome beta 2 subunit, putative 0.0617 0.1702 0.4707
Loa Loa (eye worm) proteasome subunit beta type 1 0.0996 0.2792 0.2791
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0276 0.0719 0.0718
Loa Loa (eye worm) hypothetical protein 0.0044 0.0052 0.0051
Entamoeba histolytica hypothetical protein 0.0075 0.0141 0.0389
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1282 0.3614 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0066 0.0117 0.032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0017 0.0017
Echinococcus granulosus orexin receptor type 2 0.004 0.004 0.004
Echinococcus multilocularis nmda type glutamate receptor 0.0083 0.0167 0.0167
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0212 0.0537 0.4328
Loa Loa (eye worm) hypothetical protein 0.3502 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.004 0.0318
Loa Loa (eye worm) ion channel NompC 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.0256 0.0255
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Brugia malayi follicle stimulating hormone receptor 0.004 0.004 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.0117 0.0276
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0617 0.1702 0.1702
Trypanosoma brucei proteasome beta 6 subunit 0.0996 0.2792 0.7712
Trichomonas vaginalis esterase, putative 0.0066 0.0117 0.0323
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Echinococcus multilocularis voltage dependent calcium channel 0.3502 1 1
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0617 0.1702 0.1702
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0085 0.0084
Echinococcus granulosus hypothetical protein 0.0768 0.2135 0.2135
Loa Loa (eye worm) hypothetical protein 0.0044 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0617 0.1702 0.4682
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0117 0.0322
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0212 0.0537 0.1442
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0092 0.0092
Schistosoma mansoni glutamate receptor NMDA 0.0035 0.0028 0.0028
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0212 0.0537 0.0537
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0252 0.0651 0.1799
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0212 0.0537 0.1483
Echinococcus granulosus Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Schistosoma mansoni 60S ribosomal protein L21 0.0212 0.0537 0.0537
Brugia malayi proteasome subunit beta type 2 0.0617 0.1702 0.1701
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0252 0.0651 0.1799
Giardia lamblia Proteasome subunit beta type 3 0.0252 0.0651 0.1799
Schistosoma mansoni opsin-like receptor 0.004 0.004 0.004
Echinococcus granulosus Proteasome subunit alpha beta 0.0252 0.0651 0.0651
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.009 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0057 0.0092 0.0092
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1282 0.3614 1
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi Dopamine receptor protein 1 0.004 0.004 0.0039
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0252 0.0651 0.1799
Echinococcus granulosus microtubule associated protein 2 0.1335 0.3768 0.3768
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0055 0.0086 0.0086
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0034 0.0034
Loa Loa (eye worm) proteasome subunit beta type 3 0.0252 0.0651 0.065
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0024 0.0064
Echinococcus multilocularis g protein coupled receptor 0.004 0.004 0.004
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0212 0.0537 0.0537
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0252 0.0651 0.1799
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.3502 1 1
Echinococcus granulosus nmda type glutamate receptor 0.0083 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0244 0.0628 0.0627
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0212 0.0537 0.0537
Mycobacterium tuberculosis Conserved protein 0.0066 0.0117 0.032
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0035 0.0028 0.0028
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Giardia lamblia 20S proteasome alpha subunit 6 0.0252 0.0651 0.1799
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0017 0.0016
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.004 0.004
Schistosoma mansoni survival motor neuron protein 0.005 0.007 0.007
Toxoplasma gondii heat shock protein hslv, putative 0.0252 0.0651 0.1799
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0002 0.0003
Mycobacterium ulcerans hypothetical protein 0.0066 0.0117 0.032
Leishmania major proteasome beta-1 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.004 0.004
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.004 0.004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0085 0.017 0.017
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0219 0.0219
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0085 0.017 0.017
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.009 0.0201
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.004 0.004
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.3502 1 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0252 0.0651 0.18
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0996 0.2792 0.2792
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0252 0.0651 0.0651
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.3502 1 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0052 0.0052
Loa Loa (eye worm) voltage-dependent calcium channel 0.0212 0.0537 0.0536
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0252 0.0651 0.0651
Leishmania major proteasome beta 7 subunit, putative 0.0252 0.0651 0.18
Onchocerca volvulus 0.004 0.004 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0252 0.0651 0.18
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0476 0.1297 0.1296
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0628 0.0628
Schistosoma mansoni biogenic amine receptor 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.004 0.0039
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0052 0.0052
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.004 0.004
Schistosoma mansoni transient receptor potential channel 4 0.0212 0.0537 0.0537
Echinococcus granulosus TRP transient receptor potential channel 0.0212 0.0537 0.0537
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.004 0.004
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0252 0.0651 0.1799
Leishmania major proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0199 0.0498 0.0497
Echinococcus multilocularis serotonin receptor 0.004 0.004 0.004
Schistosoma mansoni transient receptor potential channel 0.0212 0.0537 0.0537
Echinococcus multilocularis jumonji domain containing protein 0.0036 0.003 0.003
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0252 0.0651 0.1798
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.004 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0252 0.0651 0.18
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.041 0.0409
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus short transient receptor potential channel 6 0.0212 0.0537 0.0537
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0996 0.2792 0.7723
Onchocerca volvulus 0.0057 0.0092 0.0734
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004
Loa Loa (eye worm) TAR-binding protein 0.0276 0.0719 0.0718
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.004 0.004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0057 0.0092 0.0252
Toxoplasma gondii proteasome beta subunit 0.0252 0.0651 0.1799
Echinococcus granulosus sodium leak channel non selective protein 0.0212 0.0537 0.0537
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0617 0.1702 0.4707
Echinococcus multilocularis microtubule associated protein 2 0.1335 0.3768 0.3768
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.009 0.0247
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0219 0.0603
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0219 0.0218
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0252 0.0651 0.176
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0996 0.2792 0.7723
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Giardia lamblia 20S proteasome alpha subunit 3 0.0252 0.0651 0.1799
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0456 0.1261
Echinococcus granulosus calcium activated potassium channel 0.0212 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Echinococcus granulosus neuropeptide receptor 0.004 0.004 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.0903 0.0903
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Schistosoma mansoni hypothetical protein 0.034 0.0903 0.0903
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi G-protein coupled receptor 0.004 0.004 0.0039
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0252 0.0651 0.1799
Schistosoma mansoni glutamate receptor NMDA 0.0082 0.0161 0.0161
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0002 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0066 0.0117 0.0117
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Echinococcus granulosus jumonji domain containing protein 0.0036 0.003 0.003
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0252 0.0651 0.176
Leishmania major proteasome alpha 1 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0212 0.0537 0.0536
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0252 0.0651 0.18
Brugia malayi TAR-binding protein 0.0276 0.0719 0.0718
Mycobacterium tuberculosis Probable esterase LipL 0.0066 0.0117 0.032
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0252 0.0651 0.0651
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0252 0.0651 0.1799
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Echinococcus granulosus glutamate NMDA receptor subunit 0.0082 0.0161 0.0161
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0212 0.0537 0.0536
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Mycobacterium tuberculosis Probable lipase LipD 0.0066 0.0117 0.032
Echinococcus granulosus hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Echinococcus multilocularis sodium channel protein 0.0212 0.0537 0.0537
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0252 0.0651 0.0651
Schistosoma mansoni amine GPCR 0.0214 0.0543 0.0543
Echinococcus multilocularis g-protein coupled receptor 0.004 0.004 0.004
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0578 0.159 0.159
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0212 0.0537 0.0536
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.0092
Brugia malayi STAT protein, DNA binding domain containing protein 0.0174 0.0427 0.0426
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Giardia lamblia 20S proteasome alpha subunit 7 0.0252 0.0651 0.1799
Brugia malayi neuropeptide F receptor 0.004 0.004 0.0039
Trypanosoma brucei C-8 sterol isomerase, putative 0.0578 0.159 0.4372
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0026 0.0025
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0034 0.0034
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0401 0.1079 0.1079
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus granulosus snurportin 1 0.034 0.0903 0.0903
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0057 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0165 0.0401 0.04
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.004 0.004
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Brugia malayi GnHR receptor homolog 0.004 0.004 0.0039
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.004 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0212 0.0537 0.0537
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.004 0.004
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0002 0.0003
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0996 0.2792 0.2792
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0996 0.2792 0.7723
Schistosoma mansoni transient receptor potential channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0212 0.0537 0.0536
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.007 0.0069
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0252 0.0651 0.18
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0252 0.0651 0.1799
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0212 0.0537 0.0537
Echinococcus multilocularis hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Chlamydia trachomatis glutamine binding protein 0.006 0.0099 0.5
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0252 0.0651 0.065
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.009 0.0248
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0031 0.0031
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.004 0.004
Onchocerca volvulus 0.004 0.004 0.0318
Onchocerca volvulus 0.0097 0.0206 0.1657
Echinococcus multilocularis muscleblind protein 1 0.0165 0.0401 0.0401
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0252 0.0651 0.1799
Echinococcus multilocularis fmrfamide receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus proteasome subunit beta type 6 0.0252 0.0651 0.0651
Onchocerca volvulus Notchless protein homolog 0.0252 0.0651 0.5253
Echinococcus granulosus proteasome prosome macropain 0.1282 0.3614 0.3614
Echinococcus granulosus neuropeptide Y receptor 0.004 0.004 0.004
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0252 0.0651 0.1799
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.006 0.0099 0.027
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis shaker cognate 0.0212 0.0537 0.0537
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.3502 1 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0252 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni transient receptor potential channel 0.0212 0.0537 0.0537
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0035 0.0028 0.0028
Echinococcus granulosus tumor protein p63 0.1115 0.3134 0.3134
Mycobacterium leprae conserved hypothetical protein 0.0066 0.0117 0.032
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0252 0.0651 0.18
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0066 0.0117 0.032
Toxoplasma gondii proteasome subunit 0.0252 0.0651 0.1799
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0252 0.0651 0.0651
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0252 0.0651 0.0651
Schistosoma mansoni rotamase 0.0035 0.0026 0.0026
Brugia malayi Proteasome A-type and B-type family protein 0.1282 0.3614 0.3614
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.004 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0092 0.0092
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis peregrin 0.0026 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0031 0.0017 0.0016
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0212 0.0537 0.0537
Toxoplasma gondii hypothetical protein 0.0212 0.0537 0.1483
Echinococcus granulosus proteasome subunit beta t family 0.0252 0.0651 0.0651
Echinococcus multilocularis GPCR, family 2 0.0036 0.0031 0.0031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0212 0.0537 0.0537
Loa Loa (eye worm) MH2 domain-containing protein 0.0227 0.0579 0.0578
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0252 0.0651 0.176
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0219 0.0219
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.004 0.0039
Brugia malayi RNA recognition motif domain containing protein 0.0276 0.0719 0.0718
Echinococcus granulosus ryanodine receptor 44f 0.0212 0.0537 0.0537
Echinococcus multilocularis neuropeptide receptor 0.004 0.004 0.004
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Echinococcus multilocularis proteasome subunit alpha type 6 0.0252 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0053 0.008 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0693 0.1915
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.004 0.004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0028 0.0028
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Leishmania major proteasome beta 3 subunit, putative 0.0252 0.0651 0.18
Loa Loa (eye worm) beta-lactamase 0.0066 0.0117 0.0116
Brugia malayi Proteasome subunit alpha type 1 0.0252 0.0651 0.065
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.0693 0.0692
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.004 0.004
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0252 0.0651 0.1799
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis fmrfamide receptor 0.004 0.004 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0252 0.0651 0.065
Onchocerca volvulus 0.004 0.004 0.0318
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.004 0.004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.004 0.0039
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0252 0.0651 0.0651
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0034 0.0033
Schistosoma mansoni opsin-like receptor 0.004 0.004 0.004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.004 0.004
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0092 0.0091
Schistosoma mansoni adenoreceptor 0.004 0.004 0.004
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0024 0.0063
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0252 0.0651 0.1799
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0212 0.0537 0.1483
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.004 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus serotonin receptor 0.004 0.004 0.004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.004 0.004
Trypanosoma brucei glucosidase, putative 0.0037 0.0034 0.0044
Echinococcus multilocularis short transient receptor potential channel 6 0.0212 0.0537 0.0537
Brugia malayi proteasome subunit alpha type 2 0.0252 0.0651 0.065
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.004 0.004
Echinococcus multilocularis proteasome subunit beta type 6 0.0252 0.0651 0.0651
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0028 0.0028
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0252 0.0651 0.1799
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Brugia malayi Proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0212 0.0537 0.0537
Schistosoma mansoni amine GPCR 0.004 0.004 0.004
Echinococcus multilocularis tumor protein p63 0.1115 0.3134 0.3134
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0252 0.0651 0.0651
Trichomonas vaginalis D-aminoacylase, putative 0.0066 0.0117 0.0323
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0429 0.1186
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Giardia lamblia 20S proteasome alpha subunit 1 0.0252 0.0651 0.1799
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Trichomonas vaginalis rotamase, putative 0.0034 0.0024 0.0064
Echinococcus granulosus lysine specific demethylase 5A 0.0031 0.0017 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0252 0.0651 0.18
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0066 0.0117 0.0116
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0996 0.2792 0.2792
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0252 0.0651 0.0651
Brugia malayi Proteasome A-type and B-type family protein 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Schistosoma mansoni voltage-gated cation channel 0.3502 1 1
Brugia malayi hypothetical protein 0.0075 0.0141 0.014
Echinococcus granulosus neuropeptide Y receptor 0.004 0.004 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0034 0.0092
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0002 0.0003
Echinococcus granulosus shaker cognate 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Brugia malayi Pre-SET motif family protein 0.0057 0.0092 0.0091
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0252 0.0651 0.176
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.0028 0.0028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0031 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0212 0.0537 0.1483
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Onchocerca volvulus 0.004 0.004 0.0318
Schistosoma mansoni cellular tumor antigen P53 0.0163 0.0396 0.0396
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.0028 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0252 0.0651 0.0651
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0252 0.0651 0.0651
Echinococcus granulosus hyperpolarization activated cyclic 0.0212 0.0537 0.0537
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0031 0.003
Leishmania major C-8 sterol isomerase-like protein 0.0578 0.159 0.4399
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.004 0.004
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.004 0.0039
Echinococcus multilocularis ryanodine receptor 44f 0.0212 0.0537 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0026 0.0071
Brugia malayi proteasome subunit alpha type 6 0.0252 0.0651 0.065
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.004 0.004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0034 0.0092
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Leishmania major hypothetical protein, unknown function 0.0212 0.0537 0.1483
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Schistosoma mansoni calcium-activated potassium channel 0.0212 0.0537 0.0537
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0252 0.0651 0.1799
Echinococcus granulosus PHD finger protein rhinoceros 0.0026 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0078 0.0152 0.0152
Plasmodium vivax proteasome subunit beta type-5, putative 0.1282 0.3614 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0252 0.0651 0.18
Echinococcus granulosus short transient receptor potential channel 6 0.0212 0.0537 0.0537
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0252 0.0651 0.1799
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.004 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.0256 0.0255
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0212 0.0537 0.0537
Brugia malayi Cytochrome P450 family protein 0.0055 0.0085 0.0084
Echinococcus granulosus peregrin 0.0026 0.0001 0.0001
Schistosoma mansoni two-pore calcium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis short transient receptor potential channel 6 0.0212 0.0537 0.0537
Trypanosoma brucei proteasome beta 7 subunit 0.0252 0.0651 0.176
Brugia malayi Importin beta-1 subunit 0.0032 0.0018 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0117 0.0323
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.004 0.004
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0024 0.0064
Schistosoma mansoni microtubule-associated protein tau 0.1335 0.3768 0.3768
Echinococcus multilocularis proteasome (prosome, macropain) 0.1282 0.3614 0.3614
Schistosoma mansoni opsin-like receptor 0.004 0.004 0.004
Brugia malayi hypothetical protein 0.0212 0.0537 0.0536
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0252 0.0651 0.0651
Toxoplasma gondii transporter, cation channel family protein 0.0212 0.0537 0.1483
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0252 0.0651 0.0651
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0996 0.2792 0.7723
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0002 0.0001
Trypanosoma brucei proteasome alpha 7 subunit 0.0252 0.0651 0.176
Brugia malayi Serotonin receptor 0.004 0.004 0.0039
Giardia lamblia 20S proteasome alpha subunit 4 0.0252 0.0651 0.1799
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.004 0.0039
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0212 0.0537 0.1483
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Brugia malayi hypothetical protein 0.004 0.004 0.0039
Echinococcus granulosus neuropeptide s receptor 0.004 0.004 0.004
Mycobacterium ulcerans beta-lactamase 0.0066 0.0117 0.032
Trichomonas vaginalis penicillin-binding protein, putative 0.0066 0.0117 0.0323
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0252 0.0651 0.0651
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0252 0.0651 0.18
Echinococcus granulosus potassium large conductance calcium activated 0.0212 0.0537 0.0537
Onchocerca volvulus 0.0163 0.0396 0.3191
Loa Loa (eye worm) TYRA-2 protein 0.004 0.004 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Echinococcus granulosus glutamate receptor 2 0.0035 0.0028 0.0028
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0617 0.1702 0.4707
Mycobacterium ulcerans proteasome PrcB 0.1282 0.3614 1
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.004 0.004
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0719 0.0719
Brugia malayi Melatonin receptor type 1A 0.004 0.004 0.0039
Echinococcus multilocularis muscleblind protein 0.0165 0.0401 0.0401
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0456 0.1261
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.004 0.004
Toxoplasma gondii transporter, cation channel family protein 0.0212 0.0537 0.1483
Schistosoma mansoni hypothetical protein 0.005 0.007 0.007
Echinococcus multilocularis calcium activated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.3502 1 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1282 0.3614 1
Onchocerca volvulus 0.004 0.004 0.0318
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1282 0.3614 0.3614
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0344 0.0344
Trichomonas vaginalis D-aminoacylase, putative 0.0066 0.0117 0.0323
Schistosoma mansoni hypothetical protein 0.0042 0.0047 0.0047
Echinococcus granulosus g protein coupled receptor 0.004 0.004 0.004
Echinococcus multilocularis sex peptide receptor 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0078 0.0152 0.0151
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0252 0.0651 0.065
Loa Loa (eye worm) hypothetical protein 0.0165 0.0401 0.04
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0066 0.0117 0.0117
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0212 0.0537 0.0537
Echinococcus multilocularis protein dispatched 1 0.005 0.007 0.007
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0212 0.0537 0.0536
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.041 0.041
Schistosoma mansoni vesicular amine transporter 0.0212 0.0537 0.0537
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0252 0.0651 0.18
Echinococcus granulosus potassium voltage gated channel protein 0.0212 0.0537 0.0537
Mycobacterium ulcerans lipase LipD 0.0066 0.0117 0.032
Echinococcus granulosus transient receptor potential cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) RNA binding protein 0.0276 0.0719 0.0718
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus GPCR family 2 0.0036 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0026 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0024 0.0064
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0252 0.0651 0.1798
Brugia malayi beta-lactamase 0.0066 0.0117 0.0116
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.3502 1 1
Mycobacterium tuberculosis Conserved protein 0.0066 0.0117 0.032
Schistosoma mansoni neuropeptide receptor 0.004 0.004 0.004
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.004 0.0039
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0252 0.0651 0.18
Plasmodium falciparum proteasome subunit beta type-4 0.0252 0.0651 0.1799
Echinococcus granulosus muscleblind protein 0.0165 0.0401 0.0401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0034 0.0091
Echinococcus granulosus somatostatin receptor 0.004 0.004 0.004
Brugia malayi neuropeptide F receptor 0.004 0.004 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Mycobacterium tuberculosis Probable hydrolase 0.0066 0.0117 0.032
Echinococcus multilocularis two pore calcium channel protein 2 0.0212 0.0537 0.0537
Schistosoma mansoni ryanodine receptor related 0.0212 0.0537 0.0537
Echinococcus granulosus expressed protein 0.0035 0.0026 0.0026
Schistosoma mansoni voltage-dependent calcium channel 0.0212 0.0537 0.0537
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0252 0.0651 0.18
Trypanosoma cruzi hypothetical protein, conserved 0.0066 0.0117 0.0323
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1282 0.3614 1
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0252 0.0651 0.18
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0017
Onchocerca volvulus 0.004 0.004 0.0318
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.004 0.004
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0212 0.0537 0.0537
Brugia malayi Transient-receptor-potential like protein 0.0212 0.0537 0.0536
Echinococcus multilocularis potassium voltage gated channel protein 0.0212 0.0537 0.0537
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0031 0.003
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.004 0.004
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0252 0.0651 0.18
Schistosoma mansoni voltage-gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.008 0.0079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.004 0.004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.004 0.004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0066 0.0117 0.0117
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.004 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0082 0.0161 0.0161
Brugia malayi RNA, U transporter 1 0.009 0.0187 0.0186
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.004 0.004
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0252 0.0651 0.1799
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0252 0.0651 0.5
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0252 0.0651 0.18
Leishmania major proteasome beta 5 subunit, putative 0.1282 0.3614 1
Onchocerca volvulus 0.0066 0.0117 0.094
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Mycobacterium tuberculosis Conserved protein 0.0066 0.0117 0.032
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0018 0.0018
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0212 0.0537 0.0536
Echinococcus granulosus proteasome subunit alpha type 6 0.0252 0.0651 0.0651
Brugia malayi Proteasome subunit alpha type 7-1 0.0252 0.0651 0.065
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.004 0.004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.004 0.004
Echinococcus multilocularis transient receptor potential cation channel 0.0212 0.0537 0.0537
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.009 0.0247
Brugia malayi Dopamine receptor 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0476 0.1297 0.1296
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0252 0.0651 0.065
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0034 0.0092
Echinococcus multilocularis potassium large conductance calcium activated 0.0212 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.004 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Plasmodium vivax SET domain protein, putative 0.0057 0.0092 0.0252
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0252 0.0651 0.0651
Brugia malayi hypothetical protein 0.0057 0.009 0.0089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0017 0.0017
Echinococcus multilocularis lysine specific demethylase 5A 0.0031 0.0017 0.0017
Leishmania major proteasome beta 2 subunit, putative 0.0252 0.0651 0.18
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0212 0.0537 0.0536
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1282 0.3614 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.004 0.004
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0617 0.1702 0.4707
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0212 0.0537 0.0536
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0252 0.0651 0.18
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0212 0.0537 0.0537
Echinococcus multilocularis snurportin 1 0.034 0.0903 0.0903
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0066 0.0117 0.032
Brugia malayi AKH receptor 0.004 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0212 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0066 0.0117 0.0116
Toxoplasma gondii proteasome subunit alpha type, putative 0.0252 0.0651 0.1799
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.041 0.041
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0212 0.0537 0.0537
Brugia malayi RNA binding protein 0.0276 0.0719 0.0718
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.004 0.004
Schistosoma mansoni patched 1 0.0044 0.0052 0.0052
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0212 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0039
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0429 0.3461

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) CNS activity in mouse assessed as alteration of exploratory behaviour at 20 mg/kg, po ChEMBL. 833820
No. of rabbits convulsed (functional) = 0 Number of rabbits convulsed at 0.1 mg/kg,iv out of 2 rabbits tested ChEMBL. 7086846
No. of rabbits convulsed (functional) = 2 Number of rabbits convulsed at 0.5 mg/kg,iv out of 3 rabbits tested ChEMBL. 7086846
No. of rabbits convulsed (functional) = 4 Number of rabbits convulsed at 0.9 mg/kg,iv out of 4 rabbits tested ChEMBL. 7086846
Relative potency (functional) = 6.7 Capability to induce convulsions in tetrahydrocannabinol-seizure susceptible (THC-SS) rabbit ChEMBL. 7086846
Relative potency (functional) = 6.7 Capability to induce convulsions in tetrahydrocannabinol-seizure susceptible (THC-SS) rabbit ChEMBL. 7086846

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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