Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log Ki (binding) | = 5.68 | Binding affinity determined to alpha-1 adrenergic receptor of rat cerebral cortex using [3H]-prazosin as radioligand | ChEMBL. | 2153820 |
Log Ki (binding) | = 7.65 | Binding affinity to alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]-yohimbine as radioligand | ChEMBL. | 2153820 |
Log Ki (binding) | = 7.8 | Binding affinity to the alpha-2 adrenergic receptor of rat cerebral cortex assayed using [3H]-idazoxan as radioligand | ChEMBL. | 2153820 |
Ratio (binding) | = 1 | Antilog of [3H]-idazoxan pKi minus [3H]-yohimbine pKi | ChEMBL. | 2153820 |
Selectivity ratio (binding) | = 93 | Selectivity ratio for alpha 2 adrenergic receptor subpopulation, [3H]-yohimbine pKi minus [3H]-prazosin pKi | ChEMBL. | 2153820 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.