Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3009 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.3009 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3009 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3009 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.3009 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3009 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.3009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3009 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3009 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3009 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3009 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3009 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.14 | Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor | ChEMBL. | 14741248 |
Ki (binding) | = -8.02 | Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor | ChEMBL. | 14741248 |
Ki (binding) | = -7.79 | Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor | ChEMBL. | 14741248 |
Ki (binding) | = -6.97 | Binding affinity towards dopamine receptor D2 | ChEMBL. | 14741248 |
Ki (binding) | = -6.85 | Binding affinity towards serotonin 5-hydroxytryptamine 2C receptor | ChEMBL. | 14741248 |
Ki (binding) | = -6.83 | Binding affinity towards serotonin 5-hydroxytryptamine 2C receptor | ChEMBL. | 14741248 |
Ki (binding) | = -6.82 | Binding affinity towards dopamine receptor D2 | ChEMBL. | 14741248 |
Ki (binding) | = -6.79 | Binding affinity towards dopamine receptor D2 | ChEMBL. | 14741248 |
Log Ki (binding) | = 6.79 | Binding affinity towards dopamine receptor D2 | ChEMBL. | 14741248 |
Log Ki (binding) | = 6.82 | Binding affinity towards dopamine receptor D2 | ChEMBL. | 14741248 |
Log Ki (binding) | = 6.82 | Inhibitory constant towards dopamine D2 receptor was determined | ChEMBL. | 15878662 |
Log Ki (binding) | = 6.83 | Binding affinity towards serotonin 5-hydroxytryptamine 2C receptor | ChEMBL. | 14741248 |
Log Ki (binding) | = 6.83 | Inhibitory constant towards 5-hydroxytryptamine 2C receptor (5-HT2C) | ChEMBL. | 15878662 |
Log Ki (binding) | = 6.85 | Binding affinity towards serotonin 5-hydroxytryptamine 2C receptor | ChEMBL. | 14741248 |
Log Ki (binding) | = 6.97 | Binding affinity towards dopamine receptor D2 | ChEMBL. | 14741248 |
Log Ki (binding) | = 7.79 | Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor | ChEMBL. | 14741248 |
Log Ki (binding) | = 8.02 | Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor | ChEMBL. | 14741248 |
Log Ki (binding) | = 8.02 | Inhibitory constant towards 5-hydroxytryptamine 2A receptor (5-HT2A) | ChEMBL. | 15878662 |
Log Ki (binding) | = 8.14 | Binding affinity towards serotonin 5-hydroxytryptamine 2A receptor | ChEMBL. | 14741248 |
Ratio (binding) | = 1.11 | Selectivity ratio for serotonin 5-HT2A to that of dopamine D2 receptors | ChEMBL. | 14741248 |
Ratio (binding) | = 1.18 | Selectivity ratio for serotonin 5-HT2A to that of dopamine D2 receptors | ChEMBL. | 14741248 |
Ratio (binding) | = 1.18 | Ratio of inhibitory constant for 5-hydroxytryptamine 2A receptor to that of dopamine receptor D2 | ChEMBL. | 15878662 |
Ratio (binding) | = 1.2 | Selectivity ratio for serotonin 5-HT2A to that of dopamine D2 receptors | ChEMBL. | 14741248 |
Ratio (binding) | = 8.7 | Selectivity ratio for serotonin 5-HT2C to that of serotonin 5-HT2A receptors | ChEMBL. | 14741248 |
Ratio (binding) | = 15.5 | Selectivity ratio for serotonin 5-HT2C to that of serotonin 5-HT2A receptors | ChEMBL. | 14741248 |
Ratio (binding) | = 19.5 | Selectivity ratio for serotonin 5-HT2C to that of serotonin 5-HT2A receptors | ChEMBL. | 14741248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.