Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.97 uM | The compound was tested for its affinity for Ionotropic glutamate receptor AMPA in in vitro binding assay on rat cortical membrane preparations using [3H]-AMPA as ligand | ChEMBL. | 10741560 |
IC50 (binding) | = 0.97 uM | The compound was tested for its affinity for Ionotropic glutamate receptor AMPA in in vitro binding assay on rat cortical membrane preparations using [3H]-AMPA as ligand | ChEMBL. | 10741560 |
IC50 (binding) | = 1 uM | In vitro affinity for N-methyl-D-aspartate glutamate receptor 1 using [3H]-5,7-dichlorokynurenate([3H]-DCKA) as ligand | ChEMBL. | 10741560 |
IC50 (binding) | = 1 uM | In vitro affinity for N-methyl-D-aspartate glutamate receptor 1 using [3H]-5,7-dichlorokynurenate([3H]-DCKA) as ligand | ChEMBL. | 10741560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.