Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.4747 | 0.4747 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.4747 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.013 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.4747 | 0.4747 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.018 | 0.018 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0058 | 0.018 | 0.018 |
Echinococcus multilocularis | fibrillin 1 | 0.0058 | 0.018 | 0.0379 |
Echinococcus granulosus | Tolloid protein 1 | 0.0058 | 0.018 | 0.0379 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.3336 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.3336 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.4747 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.4747 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.4747 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.4747 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.4747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.4747 | 0.4747 |
Onchocerca volvulus | 0.0101 | 0.6061 | 0.5989 | |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0081 | 0.3375 | 0.3375 |
Echinococcus granulosus | laminin | 0.0058 | 0.018 | 0.0379 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.4747 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.013 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0058 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.018 | 0.018 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0058 | 0.018 | 0.018 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.4747 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0081 | 0.3375 | 0.0275 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0081 | 0.3375 | 0.711 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.018 | 0.018 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.4747 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0058 | 0.018 | 0.018 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0081 | 0.3375 | 0.3375 |
Leishmania major | hypothetical protein, conserved | 0.0081 | 0.3375 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3375 | 0.3375 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.4747 | 0.4747 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.4747 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0081 | 0.3375 | 0.3375 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.4747 | 1 |
Onchocerca volvulus | 0.013 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.3375 | 0.3375 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.4747 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0058 | 0.018 | 0.0379 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0058 | 0.018 | 0.018 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.4747 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0081 | 0.3375 | 0.711 |
Toxoplasma gondii | kringle domain-containing protein | 0.0081 | 0.3375 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0058 | 0.018 | 0.018 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.4747 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.4747 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0058 | 0.018 | 0.018 |
Brugia malayi | Fibulin-1 precursor | 0.0058 | 0.018 | 0.018 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.4747 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.4747 | 1 |
Onchocerca volvulus | 0.0081 | 0.3375 | 0.3253 | |
Echinococcus multilocularis | laminin | 0.0058 | 0.018 | 0.0379 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.4747 | 1 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.4747 | 0.4747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.2 uM | Inhibition of human inducible nitric oxide synthase | ChEMBL. | 10741561 |
IC50 (binding) | = 1.2 uM | Inhibition of human inducible nitric oxide synthase | ChEMBL. | 10741561 |
IC50 (binding) | = 11.6 uM | Inhibition of human neuronal Nitric Oxide Synthase | ChEMBL. | 10741561 |
IC50 (binding) | = 11.6 uM | Inhibition of human neuronal Nitric Oxide Synthase | ChEMBL. | 10741561 |
IC50 (binding) | = 13 uM | Inhibition of human endothelial Nitric Oxide Synthase | ChEMBL. | 10741561 |
IC50 (binding) | = 13 uM | Inhibition of human endothelial Nitric Oxide Synthase | ChEMBL. | 10741561 |
Ratio (binding) | = 10 | Ratio of binding to Neuronal nitric oxide synthase and Inducible nitric oxide synthase | ChEMBL. | 10741561 |
Ratio (binding) | = 11 | Ratio of Endothelial Nitric Oxide Synthase to Inducible nitric oxide synthase | ChEMBL. | 10741561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.