Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.0169 | 1 | 1 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.0169 | 1 | 0.5 |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.0169 | 1 | 0.5 |
Loa Loa (eye worm) | acyltransferase | 0.0169 | 1 | 1 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 0.8064 | 0.7937 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.014 | 0.8064 | 0.8064 |
Brugia malayi | hypothetical protein | 0.0027 | 0.062 | 0.062 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.0169 | 1 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0156 | 0.9112 | 0.541 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus multilocularis | homeobox | 0.0162 | 0.9543 | 0.7638 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0169 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.9543 | 0.9513 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.0169 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.9112 | 0.541 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 0.8064 | 0.7937 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.0169 | 1 | 0.5 |
Echinococcus granulosus | Msx-like | 0.0162 | 0.9543 | 0.7638 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 0.8064 | 0.8064 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 0.8064 | 0.7937 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0169 | 1 | 1 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.0169 | 1 | 1 |
Schistosoma mansoni | transcription factor | 0.0162 | 0.9543 | 0.7638 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0156 | 0.9112 | 0.541 |
Brugia malayi | TAR-binding protein | 0.014 | 0.8064 | 0.8064 |
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.0169 | 1 | 0.5 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0169 | 1 | 1 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0169 | 1 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.9112 | 0.9053 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.9112 | 0.541 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.0169 | 1 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.9112 | 0.9053 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 355 nM | In vitro inhibitory concentration against radioligand [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane. | ChEMBL. | 9046348 |
IC50 (binding) | = 355 nM | In vitro inhibitory concentration against radioligand [3H]-8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor in rat hippocampal membrane. | ChEMBL. | 9046348 |
IC50 (binding) | = 886 nM | In vitro inhibitory concentration against radioligand [3H]-prazosin binding to alpha-1 adrenergic receptor in rat cortical membrane. | ChEMBL. | 9046348 |
IC50 (binding) | = 886 nM | In vitro inhibitory concentration against radioligand [3H]-prazosin binding to alpha-1 adrenergic receptor in rat cortical membrane. | ChEMBL. | 9046348 |
Selectivity (binding) | = 2.5 | Selectivity for alpha1-adrenergic receptor to that of 5-HT1A receptor. | ChEMBL. | 9046348 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.