Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclin k | 0.003 | 0.0262 | 0.0345 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0152 | 0.3939 | 0.7792 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0045 | 0.0708 | 0.0607 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Schistosoma mansoni | proteasome subunit alpha 1 (T01 family) | 0.003 | 0.0262 | 0.0345 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0097 | 0.2264 | 0.2152 |
Schistosoma mansoni | cyclin G2 | 0.003 | 0.0262 | 0.0345 |
Brugia malayi | Sushi domain | 0.0052 | 0.0918 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.3939 | 0.3851 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0262 | 0.0345 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0097 | 0.2264 | 0.2726 |
Trichomonas vaginalis | cyclins, putative | 0.0126 | 0.3142 | 0.7834 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0918 | 0.0673 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Giardia lamblia | Kinase, CMGC CDK | 0.0097 | 0.2264 | 0.5445 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0052 | 0.0918 | 0.0787 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Brugia malayi | Protein kinase domain containing protein | 0.0056 | 0.1036 | 0.0794 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0374 | 0.0235 |
Echinococcus granulosus | insulin receptor | 0.0056 | 0.1036 | 0.1053 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0045 | 0.0708 | 0.0607 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0097 | 0.2264 | 0.2152 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.012 | 0.2969 | 0.3687 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0065 | 0.1299 | 0.2197 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0097 | 0.2264 | 0.2726 |
Plasmodium falciparum | apical sushi protein | 0.0052 | 0.0918 | 0.1389 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0065 | 0.1299 | 0.2197 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.2202 | 0.209 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0045 | 0.0708 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.3939 | 0.3851 |
Trichomonas vaginalis | cyclins, putative | 0.0152 | 0.3939 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0065 | 0.1299 | 0.1064 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0097 | 0.2264 | 0.4242 |
Echinococcus granulosus | cyclins | 0.0126 | 0.3142 | 0.3922 |
Schistosoma mansoni | tyrosine kinase | 0.0056 | 0.1036 | 0.1362 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0353 | 1 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0126 | 0.3142 | 0.4132 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0065 | 0.1299 | 0.1411 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0126 | 0.3142 | 0.3922 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0034 | 0.0374 | 0.0492 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0097 | 0.2264 | 0.2726 |
Trichomonas vaginalis | cyclin B, putative | 0.0152 | 0.3939 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0034 | 0.0374 | 0.0152 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0041 | 0.059 | 0.0447 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0164 | 0.429 | 0.4136 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0091 | 0.2077 | 0.2471 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0918 | 0.0673 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.012 | 0.2969 | 0.3687 |
Entamoeba histolytica | cyclin family protein | 0.0126 | 0.3142 | 0.7834 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0097 | 0.2264 | 0.5445 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.084 | 0.0707 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0065 | 0.1299 | 0.2197 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0037 | 0.047 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0056 | 0.1036 | 0.0906 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0065 | 0.1299 | 0.2197 |
Schistosoma mansoni | Cyclin fold protein | 0.003 | 0.0262 | 0.0345 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0187 | 0.4981 | 0.6426 |
Loa Loa (eye worm) | cyclin fold protein 1 variant b | 0.003 | 0.0262 | 0.0122 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Trichomonas vaginalis | cyclins, putative | 0.0152 | 0.3939 | 1 |
Echinococcus multilocularis | 0.0049 | 0.0827 | 0.0768 | |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0065 | 0.1299 | 0.2197 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0065 | 0.1299 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.0152 | 0.3939 | 0.7792 |
Loa Loa (eye worm) | SRC-1 | 0.0045 | 0.0708 | 0.0574 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0097 | 0.2264 | 0.4242 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0091 | 0.2077 | 0.2471 |
Toxoplasma gondii | hypothetical protein | 0.0095 | 0.2226 | 0.4163 |
Echinococcus multilocularis | cyclins | 0.0126 | 0.3142 | 0.3922 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Echinococcus granulosus | cyclins | 0.0126 | 0.3142 | 0.3922 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0052 | 0.0918 | 0.1389 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0187 | 0.4981 | 0.6426 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0034 | 0.0374 | 0.0115 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0045 | 0.0708 | 0.0607 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0052 | 0.0918 | 0.0893 |
Echinococcus multilocularis | roundabout 2 | 0.005 | 0.084 | 0.0786 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.012 | 0.2969 | 0.3687 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0052 | 0.0918 | 0.0893 |
Plasmodium falciparum | thioredoxin reductase | 0.0187 | 0.4981 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0129 | 0.3232 | 0.305 |
Trypanosoma cruzi | cyclin 6, putative | 0.0152 | 0.3939 | 0.7792 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0045 | 0.0708 | 0.0607 |
Echinococcus multilocularis | cyclins | 0.0126 | 0.3142 | 0.3922 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.003 | 0.0262 | 0.0122 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0041 | 0.0577 | 0.0429 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0045 | 0.0708 | 0.0607 |
Echinococcus granulosus | cyclins | 0.0126 | 0.3142 | 0.3922 |
Schistosoma mansoni | vesicular amine transporter | 0.0034 | 0.0374 | 0.0492 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0065 | 0.1299 | 0.5 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0065 | 0.1299 | 0.2197 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0281 | 0.7832 | 0.7774 |
Brugia malayi | Protein kinase domain containing protein | 0.0277 | 0.7701 | 0.7639 |
Plasmodium vivax | protein kinase Crk2 | 0.0097 | 0.2264 | 0.4242 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0097 | 0.2264 | 0.2726 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.012 | 0.2969 | 0.3687 |
Loa Loa (eye worm) | TK protein kinase | 0.0041 | 0.059 | 0.0454 |
Brugia malayi | protein-tyrosine kinase | 0.0041 | 0.059 | 0.0337 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0052 | 0.0918 | 0.0893 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0056 | 0.1036 | 0.1053 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Schistosoma mansoni | g1/s-specific cyclin C | 0.003 | 0.0262 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0065 | 0.1299 | 0.5 |
Plasmodium vivax | apical sushi protein, putative | 0.0052 | 0.0918 | 0.1389 |
Brugia malayi | cell division control protein 2 homolog | 0.0097 | 0.2264 | 0.2056 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0097 | 0.2264 | 0.4242 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0037 | 0.047 | 0.0282 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0045 | 0.0708 | 0.0607 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.1889 | 0.2484 |
Schistosoma mansoni | cell adhesion molecule | 0.0041 | 0.0577 | 0.0759 |
Plasmodium falciparum | thioredoxin reductase | 0.0065 | 0.1299 | 0.2197 |
Entamoeba histolytica | cyclin family protein | 0.0126 | 0.3142 | 0.7834 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0097 | 0.2264 | 0.2726 |
Trypanosoma brucei | trypanothione reductase | 0.0187 | 0.4981 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0041 | 0.059 | 0.0447 |
Trichomonas vaginalis | cyclin B, putative | 0.0152 | 0.3939 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0126 | 0.3142 | 0.7834 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0065 | 0.1299 | 0.2197 |
Brugia malayi | Protein kinase domain containing protein | 0.0097 | 0.2264 | 0.2056 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0097 | 0.2264 | 0.4242 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0052 | 0.0918 | 0.0673 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0065 | 0.1299 | 0.2819 |
Schistosoma mansoni | tyrosine kinase | 0.0045 | 0.0708 | 0.0931 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0152 | 0.3939 | 0.7792 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Loa Loa (eye worm) | TK protein kinase | 0.0037 | 0.047 | 0.0332 |
Echinococcus granulosus | cyclin B | 0.0152 | 0.3939 | 0.5007 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0374 | 0.0235 |
Leishmania major | cyclin | 0.0152 | 0.3939 | 0.7792 |
Echinococcus multilocularis | neuroglian | 0.0043 | 0.0637 | 0.051 |
Echinococcus granulosus | tyrosine kinase | 0.0041 | 0.059 | 0.0447 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0065 | 0.1299 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0056 | 0.1036 | 0.1053 |
Trypanosoma cruzi | cyclin, putative | 0.0152 | 0.3939 | 0.7792 |
Schistosoma mansoni | nephrin | 0.0043 | 0.0637 | 0.0837 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.084 | 0.0707 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0065 | 0.1299 | 0.2197 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0052 | 0.0918 | 0.0673 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0097 | 0.2264 | 0.4242 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0065 | 0.1299 | 0.2819 |
Trichomonas vaginalis | cyclin D, putative | 0.0126 | 0.3142 | 0.7834 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0164 | 0.429 | 0.4208 |
Echinococcus granulosus | roundabout 2 | 0.005 | 0.084 | 0.0786 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0065 | 0.1299 | 0.2819 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Echinococcus granulosus | cyclin b3 | 0.0126 | 0.3142 | 0.3922 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1094 | 0.0965 |
Loa Loa (eye worm) | TK protein kinase | 0.0129 | 0.3232 | 0.3134 |
Treponema pallidum | NADH oxidase | 0.0065 | 0.1299 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0126 | 0.3142 | 0.7834 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0187 | 0.4981 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0034 | 0.0374 | 0.0492 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0152 | 0.3939 | 0.7792 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0052 | 0.0918 | 0.1389 |
Schistosoma mansoni | tyrosine kinase | 0.0045 | 0.0708 | 0.0931 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0065 | 0.1299 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0126 | 0.3142 | 0.3922 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0045 | 0.0708 | 0.0607 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.1889 | 0.2484 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0374 | 0.0115 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0065 | 0.1299 | 0.2197 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0097 | 0.2264 | 0.5445 |
Schistosoma mansoni | tyrosine kinase | 0.0084 | 0.1889 | 0.2484 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0065 | 0.1299 | 0.2197 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0152 | 0.3939 | 0.3775 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0035 | 0.0402 | 0.019 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0097 | 0.2264 | 0.4242 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0274 | 0.7605 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0152 | 0.3939 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0918 | 0.0673 |
Plasmodium falciparum | glutathione reductase | 0.0065 | 0.1299 | 0.2197 |
Loa Loa (eye worm) | CYL-1 protein | 0.003 | 0.0262 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0918 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0374 | 0.0235 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0034 | 0.0374 | 0.0115 |
Echinococcus granulosus | defective proboscis extension response | 0.0034 | 0.0374 | 0.0152 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0035 | 0.0402 | 0.019 |
Plasmodium falciparum | protein kinase 5 | 0.0097 | 0.2264 | 0.4242 |
Schistosoma mansoni | tyrosine kinase | 0.012 | 0.2969 | 0.3904 |
Echinococcus multilocularis | cyclin B3 1 | 0.0126 | 0.3142 | 0.3922 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0262 | 0.0345 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0097 | 0.2264 | 0.2726 |
Echinococcus granulosus | cyclin dependent kinase | 0.0097 | 0.2264 | 0.2726 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0065 | 0.1299 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0041 | 0.059 | 0.0447 |
Echinococcus multilocularis | cyclins | 0.0126 | 0.3142 | 0.3922 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0041 | 0.059 | 0.0447 |
Loa Loa (eye worm) | glutathione reductase | 0.0187 | 0.4981 | 0.4908 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0045 | 0.0708 | 0.0607 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0187 | 0.4981 | 0.4908 |
Entamoeba histolytica | protein kinase, putative | 0.0037 | 0.047 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0577 | 0.0441 |
Trichomonas vaginalis | cyclin B, putative | 0.0152 | 0.3939 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0097 | 0.2264 | 0.2726 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.003 | 0.0262 | 0.0122 |
Echinococcus granulosus | cyclins | 0.0126 | 0.3142 | 0.3922 |
Schistosoma mansoni | cyclin G | 0.003 | 0.0262 | 0.0345 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0126 | 0.3142 | 0.3043 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Schistosoma mansoni | tyrosine kinase | 0.0056 | 0.1036 | 0.1362 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0321 | 0.9032 | 1 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0918 | 0.0673 |
Entamoeba histolytica | cyclin, putative | 0.0152 | 0.3939 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.2264 | 0.2977 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Trichomonas vaginalis | cyclins, putative | 0.0057 | 0.1059 | 0.2166 |
Giardia lamblia | Kinase, CMGC CDK | 0.0097 | 0.2264 | 0.5445 |
Echinococcus multilocularis | cyclins | 0.0126 | 0.3142 | 0.3922 |
Trichomonas vaginalis | cyclin D, putative | 0.0126 | 0.3142 | 0.7834 |
Echinococcus granulosus | Immunoglobulin | 0.0034 | 0.0374 | 0.0152 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0097 | 0.2264 | 0.4242 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0152 | 0.3939 | 0.3775 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Loa Loa (eye worm) | cyclin C | 0.003 | 0.0262 | 0.0122 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.003 | 0.0262 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0374 | 0.0235 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0065 | 0.1299 | 0.2197 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.003 | 0.0262 | 0.0122 |
Schistosoma mansoni | tyrosine kinase | 0.0091 | 0.2077 | 0.2731 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0045 | 0.0708 | 0.0607 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.2264 | 0.2977 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0152 | 0.3939 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0187 | 0.4981 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0056 | 0.1036 | 0.1053 |
Schistosoma mansoni | cyclin d | 0.003 | 0.0262 | 0.0345 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0065 | 0.1299 | 0.2197 |
Echinococcus granulosus | neuroglian | 0.0043 | 0.0637 | 0.051 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0097 | 0.2264 | 0.2152 |
Giardia lamblia | Hypothetical protein | 0.0126 | 0.3142 | 0.7834 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0045 | 0.0708 | 0.0607 |
Echinococcus multilocularis | cyclins | 0.0126 | 0.3142 | 0.3922 |
Trichomonas vaginalis | cyclin B, putative | 0.0126 | 0.3142 | 0.7834 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0045 | 0.0708 | 0.0607 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0918 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Echinococcus granulosus | twitchin | 0.0045 | 0.0698 | 0.0594 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0277 | 0.7701 | 0.7668 |
Schistosoma mansoni | tyrosine kinase | 0.0274 | 0.7605 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0065 | 0.1299 | 0.1708 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0091 | 0.2077 | 0.2471 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0187 | 0.4981 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0097 | 0.2264 | 0.5445 |
Echinococcus granulosus | cyclins | 0.0126 | 0.3142 | 0.3922 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0048 | 0.0781 | 0.0532 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0097 | 0.2264 | 0.5445 |
Brugia malayi | SRC-1 | 0.0045 | 0.0708 | 0.0458 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0065 | 0.1299 | 0.2197 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0052 | 0.0918 | 0.0893 |
Echinococcus multilocularis | cyclin b3 | 0.0126 | 0.3142 | 0.3922 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0164 | 0.429 | 0.5485 |
Plasmodium falciparum | glutathione reductase | 0.0187 | 0.4981 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0091 | 0.2077 | 0.2731 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0065 | 0.1299 | 0.1411 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0052 | 0.0918 | 0.1207 |
Schistosoma mansoni | cyclins | 0.0126 | 0.3142 | 0.4132 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0041 | 0.059 | 0.0447 |
Trichomonas vaginalis | cyclins, putative | 0.0152 | 0.3939 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0187 | 0.4981 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0045 | 0.0708 | 0.0607 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0048 | 0.0781 | 0.0532 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0126 | 0.3142 | 0.2958 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0045 | 0.0708 | 0.0607 |
Echinococcus granulosus | protein tyrosine kinase | 0.0274 | 0.7605 | 1 |
Onchocerca volvulus | 0.0306 | 0.8581 | 0.9486 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0126 | 0.3142 | 0.7834 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0164 | 0.429 | 0.5485 |
Toxoplasma gondii | thioredoxin reductase | 0.0187 | 0.4981 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0034 | 0.0374 | 0.0152 |
Leishmania major | trypanothione reductase | 0.0187 | 0.4981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0374 | 0.0235 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0126 | 0.3142 | 0.3922 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0097 | 0.2264 | 0.4242 |
Brugia malayi | glutathione reductase | 0.0187 | 0.4981 | 0.4845 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0097 | 0.2264 | 0.4242 |
Onchocerca volvulus | 0.0152 | 0.3939 | 0.4192 | |
Trichomonas vaginalis | cyclin A, putative | 0.0152 | 0.3939 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0281 | 0.7832 | 0.7801 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0918 | 0.0673 |
Echinococcus multilocularis | Immunoglobulin | 0.0034 | 0.0374 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0262 | 0.0122 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.003 | 0.0262 | 0.0122 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0045 | 0.0708 | 0.0607 |
Onchocerca volvulus | 0.0052 | 0.0918 | 0.0747 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Brugia malayi | Thioredoxin reductase | 0.0187 | 0.4981 | 0.4845 |
Echinococcus granulosus | cyclin B3 1 | 0.0126 | 0.3142 | 0.3922 |
Trichomonas vaginalis | cyclins, putative | 0.0152 | 0.3939 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0065 | 0.1299 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0065 | 0.1299 | 0.2197 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0047 | 0.077 | 0.0691 |
Schistosoma mansoni | cyclin B | 0.0152 | 0.3939 | 0.5179 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0374 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0918 | 0.0787 |
Giardia lamblia | Cyclin A | 0.0126 | 0.3142 | 0.7834 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0262 | 0.0122 |
Schistosoma mansoni | cyclin l | 0.003 | 0.0262 | 0.0345 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0045 | 0.0708 | 0.0607 |
Echinococcus multilocularis | cyclin B | 0.0152 | 0.3939 | 0.5007 |
Echinococcus multilocularis | cyclins | 0.0126 | 0.3142 | 0.3922 |
Plasmodium falciparum | cyclin | 0.0126 | 0.3142 | 0.6104 |
Schistosoma mansoni | tyrosine kinase | 0.0164 | 0.429 | 0.5641 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0097 | 0.2264 | 0.5445 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Bathochromic shift (functional) | = 8 nm | Absorption spectral changes upon addition of 200 microM calf thymus DNA to drug solution at 20 uM in 1 mM Na cacodylate buffer at pH 7.0 | ChEMBL. | 12477365 |
Delta Tm (functional) | = 4.6 degrees C | Variation in melting temperature performed in BPE buffer at pH 7.1,using 10 uM drug and 20 uM calf thymus DNA (CT) | ChEMBL. | 12477365 |
Delta Tm (functional) | = 12.8 degrees C | Variation in melting temperature performed in BPE buffer at pH 7.1,using 10 uM drug and 20 uM calf thymus poly (dAT) | ChEMBL. | 12477365 |
Hypochromic shift (functional) | = 35.8 % | Absorption spectral changes upon addition of 200 microM calf thymus DNA to drug solution at 20 uM in 1 mM Na cacodylate buffer at pH 7.0 | ChEMBL. | 12477365 |
K app x10e6 (functional) | = 0.2 M-1 | Binding constant to reduce by 50% the fluorescence of ethidium bromide bound to calf thymus DNA | ChEMBL. | 12477365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.