Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Nitric oxide synthase, inducible | 0.0226 | 0.8159 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0255 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0255 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0129 | 0.1964 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0255 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0127 | 0.1841 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0255 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0158 | 0.3805 | 0.3805 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0255 | 1 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0098 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0255 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0255 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0255 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0098 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0255 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0255 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0255 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0127 | 0.1841 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0226 | 0.8159 | 0.8159 |
Leishmania major | p450 reductase, putative | 0.0255 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0158 | 0.3805 | 0.2407 |
Brugia malayi | FAD binding domain containing protein | 0.0158 | 0.3805 | 0.3805 |
Giardia lamblia | Hypothetical protein | 0.0226 | 0.8159 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0255 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0226 | 0.8159 | 0.8159 |
Trypanosoma cruzi | p450 reductase, putative | 0.0255 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0255 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0098 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0255 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0158 | 0.3805 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0098 | 0 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0226 | 0.8159 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0098 | 0 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0255 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0098 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0255 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0255 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 5 % | Inhibition of [3H]-thymidine uptake in L1210 cells in the presence of 5 mg/mL human AGP at 1 uM | ChEMBL. | 15369395 |
Inhibition (functional) | = 5 % | Inhibition of [3H]-thymidine uptake in L1210 cells in the presence of 5 mg/mL human AGP at 1 uM | ChEMBL. | 15369395 |
Inhibition (functional) | = 10.3 % | Inhibition of [3H]-thymidine uptake into L1210 cells at a concentration of 1 microM in the presence of 5 mg/mL of AGP (alpha1-acid glycoprotein) | ChEMBL. | 10741559 |
Inhibition (functional) | = 10.3 % | Inhibition of [3H]-thymidine uptake into L1210 cells at a concentration of 1 microM in the presence of 5 mg/mL of AGP (alpha1-acid glycoprotein) | ChEMBL. | 10741559 |
Inhibition (functional) | = 39 % | Inhibition of [3H]-thymidine uptake into L1210 cells at a concentration of 1 microM | ChEMBL. | 10741559 |
Inhibition (functional) | = 39 % | Inhibition of [3H]-thymidine uptake in L1210 cells at 1 uM | ChEMBL. | 15369395 |
Inhibition (functional) | = 39 % | Inhibition of [3H]-thymidine uptake into L1210 cells at a concentration of 1 microM | ChEMBL. | 10741559 |
Inhibition (functional) | = 39 % | Inhibition of [3H]-thymidine uptake in L1210 cells at 1 uM | ChEMBL. | 15369395 |
Reduction (functional) | = 86 % | Reduction of [3H]-thymidine uptake into L1210 cells at a concentration of 1 microM | ChEMBL. | 10741559 |
Reduction (functional) | = 86 % | Tested for the reduction in inhibition of [3H]-thymidine uptake in L1210 cells in the presence of 5 mg/mL human AGP | ChEMBL. | 15369395 |
Reduction (functional) | = 86 % | Reduction of [3H]-thymidine uptake into L1210 cells at a concentration of 1 microM | ChEMBL. | 10741559 |
Reduction (functional) | = 86 % | Tested for the reduction in inhibition of [3H]-thymidine uptake in L1210 cells in the presence of 5 mg/mL human AGP | ChEMBL. | 15369395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.