TDR Targets

Basic information

Technical information

TDR Targets ID: 267273
Name: N,N-dimethyl-2-[[1-(4-methylpyridin-2-yl)imid azol-2-yl]sulfinylmethyl]aniline
MW: 340.443 | Formula: C18H20N4OS
H donors: 0 H acceptors: 3 LogP: 3.21 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccnc(c1)n1ccnc1[S+](Cc1ccccc1N(C)C)[O-]
InChi: 1S/C18H20N4OS/c1-14-8-9-19-17(12-14)22-11-10-20-18(22)24(23)13-15-6-4-5-7-16(15)21(2)3/h4-12H,13H2,1-3H3
InChiKey: IOGRHGJCBOACKK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N,N-dimethyl-2-[[1-(4-methyl-2-pyridyl)imidazol-2-yl]sulfinylmethyl]aniline
N,N-dimethyl-2-[[1-(4-methyl-2-pyridyl)-2-imidazolyl]sulfinylmethyl]aniline
dimethyl-[2-[[1-(4-methyl-2-pyridyl)imidazol-2-yl]sulfinylmethyl]phenyl]amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Potassium-transporting ATPase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	21.3 %
Onchocerca volvulus	Glutamate carboxypeptidase 2 homolog	Potassium-transporting ATPase	290 aa	301 aa	25.9 %
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	266 aa	25.6 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	254 aa	23.6 %
Drosophila melanogaster	nervana 1	Potassium-transporting ATPase	290 aa	305 aa	23.9 %
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Potassium-transporting ATPase	290 aa	258 aa	24.4 %
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	266 aa	24.1 %
Echinococcus granulosus	nervana 2	Potassium-transporting ATPase	290 aa	280 aa	29.3 %
Echinococcus multilocularis	nervana 2	Potassium-transporting ATPase	290 aa	280 aa	29.6 %
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	27.3 %
Loa Loa (eye worm)	hypothetical protein	Potassium-transporting ATPase	290 aa	301 aa	25.9 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	306 aa	26.1 %
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta, putative	Potassium-transporting ATPase	290 aa	256 aa	25.4 %
Schistosoma japonicum	ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative	Potassium-transporting ATPase	290 aa	258 aa	23.6 %
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	27.3 %
Echinococcus multilocularis	nervana 2	Potassium-transporting ATPase	290 aa	265 aa	22.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.001	0.0352	0.2249
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.2966	0.2796
Loa Loa (eye worm)	Notch2	0.0009	0.0237	0.0237
Onchocerca volvulus		0.0069	1	1
Onchocerca volvulus	Peroxidase homolog	0.0069	1	1
Loa Loa (eye worm)	calcium ATPase	0.001	0.0352	0.0352
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.2966	0.2796
Brugia malayi	EGF-like domain containing protein	0.0009	0.0237	0.0237
Schistosoma mansoni	ATPase	0.0017	0.1564	0.136
Loa Loa (eye worm)	blistered cuticle protein 3	0.0069	1	1
Trypanosoma brucei	P-type H+-ATPase, putative	0.0011	0.0554	0.3012
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Brugia malayi	Animal haem peroxidase family protein	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Onchocerca volvulus		0.0026	0.2966	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0017	0.1564	0.136
Brugia malayi	Na,K-ATPase alpha subunit	0.0017	0.1564	0.1564
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0008	0.0119	0.0119
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0017	0.1564	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Brugia malayi	GCC2 and GCC3 family protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0014	0.101	0.4509
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0011	0.0554	0.3545
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0017	0.1564	0.136
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0017	0.1564	0.1564
Leishmania major	calcium motive p-type ATPase, putative	0.0014	0.101	0.4509
Brugia malayi	Peroxidasin	0.0069	1	1
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0014	0.101	0.0792
Onchocerca volvulus		0.0026	0.2966	0.2796
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0017	0.1564	1
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0014	0.101	0.0792
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0012	0.0674	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0014	0.101	0.0792
Brugia malayi	Delta serrate ligand family protein	0.0009	0.0237	0.0237
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.2966	0.2796
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Echinococcus multilocularis	peroxidasin	0.0069	1	1
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0017	0.1564	1
Brugia malayi	Blistered cuticle protein 3	0.0069	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0069	1	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0008	0.0119	0.0762
Echinococcus granulosus	calcium transporting atpase	0.0014	0.101	0.0792
Echinococcus multilocularis	nervana 2	0.0026	0.2966	0.2796
Loa Loa (eye worm)	E1-E2 ATPase	0.0011	0.0554	0.0554
Brugia malayi	Membrane calcium atpase protein 3	0.0014	0.101	0.101
Toxoplasma gondii	EGF family domain-containing protein	0.0009	0.0237	0.1512
Brugia malayi	Animal haem peroxidase family protein	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0026	0.2966	0.2796
Leishmania major	calcium-transporting ATPase, putative	0.0014	0.101	0.4509
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0014	0.101	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.2966	0.2796
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0017	0.1564	1
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0014	0.101	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0017	0.1564	1
Onchocerca volvulus	Dual oxidase homolog	0.0069	1	1
Echinococcus multilocularis	nervana 2	0.0026	0.2966	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Brugia malayi	EGF-like domain containing protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	animal heme peroxidase	0.0069	1	1
Plasmodium vivax	calcium-transporting ATPase, putative	0.0017	0.1564	0.5
Brugia malayi	EGF-like domain containing protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0119	0.0119
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.001	0.0352	0.0352
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0014	0.101	0.0792
Echinococcus multilocularis	nervana 2	0.0026	0.2966	0.2796
Onchocerca volvulus		0.0017	0.1564	0.136
Brugia malayi	EGF-like domain containing protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Loa Loa (eye worm)	notch protein	0.0009	0.0237	0.0237
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0014	0.101	0.0792
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0017	0.1564	1
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0017	0.1564	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0009	0.0237	0.0237
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0014	0.101	0.6455
Brugia malayi	notch-like transmembrane receptor	0.0009	0.0237	0.0237
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.2966	0.2796
Plasmodium vivax	P-type ATPase4, putative	0.0017	0.1564	0.5
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0014	0.101	0.0792
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Onchocerca volvulus		0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Brugia malayi	EGF-like domain containing protein	0.0009	0.0237	0.0237
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0026	0.2966	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0017	0.1564	1
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0017	0.1564	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0012	0.0674	0.0674
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0017	0.1564	1
Loa Loa (eye worm)	animal heme peroxidase	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Onchocerca volvulus		0.0069	1	1
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0011	0.0554	0.3545
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0014	0.101	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Schistosoma mansoni	transmemberane protein	0.0026	0.2966	0.2796
Schistosoma mansoni	peroxidasin	0.0069	1	1
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0017	0.1564	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.2966	0.2796
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0014	0.101	0.6163
Loa Loa (eye worm)	hypothetical protein	0.0017	0.1564	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0014	0.101	0.6455
Onchocerca volvulus	Peroxidasin homolog	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.2966	0.2796
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0017	0.1564	0.136
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Brugia malayi	E1-E2 ATPase family protein	0.0011	0.0554	0.0554
Brugia malayi	Animal haem peroxidase family protein	0.0069	1	1
Leishmania major	calcium-translocating P-type ATPase	0.0017	0.1564	1
Brugia malayi	Cadherin domain containing protein	0.0009	0.0237	0.0237
Echinococcus multilocularis	calcium transporting atpase	0.0014	0.101	0.0792
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0014	0.101	0.5824
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0014	0.101	0.0792
Echinococcus granulosus	nervana 2	0.0026	0.2966	0.2796
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0012	0.0674	0.0674
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0017	0.1564	0.136
Schistosoma mansoni	ATPase	0.0017	0.1564	0.136
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0014	0.101	0.0792
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0026	0.2966	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Echinococcus granulosus	peroxidasin	0.0069	1	1
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0014	0.101	0.6455
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0017	0.1564	0.136
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.1564	1
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0017	0.1564	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0009	0.0237	0.0237
Toxoplasma gondii	P-type ATPase4, putative	0.0017	0.1564	1
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0014	0.101	0.6163
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.1564	1
Leishmania major	P-type ATPase, putative	0.0014	0.101	0.4509
Loa Loa (eye worm)	hypothetical protein	0.0026	0.2966	0.2966
Echinococcus granulosus	nervana 2	0.0026	0.2966	0.2796
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.2966	0.2796
Echinococcus granulosus	nervana 2	0.0026	0.2966	0.2796
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0017	0.1564	0.136
Onchocerca volvulus	Chorion peroxidase homolog	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0017	0.1564	1
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0012	0.0674	0.5
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0008	0.0119	0.0119
Toxoplasma gondii	P-type ATPase PMA1	0.0011	0.0554	0.3545
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0014	0.101	0.0792
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.2966	0.2796
Onchocerca volvulus	Peroxidasin homolog	0.0069	1	1
Brugia malayi	EGF-like domain containing protein	0.0009	0.0237	0.0237
Brugia malayi	Calcium binding EGF domain containing protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Brugia malayi	Animal haem peroxidase family protein	0.0069	1	1
Brugia malayi	Cadherin domain containing protein	0.0009	0.0237	0.0237
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0017	0.1564	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.1564	1
Brugia malayi	Muscle positioning protein 4	0.0009	0.0237	0.0237
Brugia malayi	Animal haem peroxidase family protein	0.0069	1	1
Onchocerca volvulus	Peroxidase homolog	0.0069	1	1
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0014	0.101	0.101
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0017	0.1564	0.136
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0017	0.1564	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	animal heme peroxidase	0.0069	1	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.1564	1
Echinococcus multilocularis	nervana 2	0.0026	0.2966	0.2796
Trypanosoma brucei	P-type H+-ATPase, putative	0.0011	0.0554	0.3012
Loa Loa (eye worm)	hypothetical protein	0.0069	1	1
Schistosoma mansoni	peroxidasin	0.0069	1	1
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.001	0.0352	0.2249
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0017	0.1564	0.1564
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0014	0.101	0.5824
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0009	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0026	0.2966	0.2966
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0017	0.1564	1
Brugia malayi	EGF-like domain containing protein	0.0009	0.0237	0.0237
Echinococcus granulosus	nervana 2	0.0026	0.2966	0.2796

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.5 uM	In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles	ChEMBL.	8558532
IC50 (binding)	= 2.5 uM	In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles	ChEMBL.	8558532
Inhibition (functional)	= 79 %	Gastric antisecretory activity was tested in rats at 30 mg/kg, po expressed as the percentage of inhibition against the acid output of the control group	ChEMBL.	8558532
Inhibition (functional)	= 79 %	Gastric antisecretory activity was tested in rats at 30 mg/kg, po expressed as the percentage of inhibition against the acid output of the control group	ChEMBL.	8558532

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10569163

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 267273