Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 nM | In vitro inhibition of rat liver HMG-CoA reductase | ChEMBL. | 2296036 |
IC50 (binding) | = 50 nM | Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]-acetate into cholesterol. | ChEMBL. | 2296036 |
Relative potency (binding) | = 1 | Relative inhibition of HMG-CoA reductase compared to Mevinolin. | ChEMBL. | 2296036 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.