Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.0091 | 0.0144 | 0.0144 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.4153 | 1 | 1 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0787 | 0.1831 | 0.1831 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4153 | 1 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1948 | 0.465 | 0.5 |
Mycobacterium ulcerans | putative regulatory protein | 0.0066 | 0.0082 | 0.0082 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0383 | 0.0383 |
Toxoplasma gondii | hypothetical protein | 0.0066 | 0.0082 | 0.5 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Toxoplasma gondii | hypothetical protein | 0.0066 | 0.0082 | 0.5 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0812 | 0.1893 | 0.1893 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0144 | 0.0144 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.4153 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0066 | 0.0082 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.171 | 0.4071 | 0.4071 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.0328 | 0.0328 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0328 | 0.0328 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Echinococcus granulosus | geminin | 0.019 | 0.0383 | 0.0383 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0091 | 0.0144 | 0.0144 |
Plasmodium falciparum | GAF domain-related protein, putative | 0.0066 | 0.0082 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0721 | 0.1671 | 0.1671 |
Echinococcus multilocularis | protein patched | 0.171 | 0.4071 | 0.4071 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.171 | 0.4071 | 0.4071 |
Mycobacterium ulcerans | putative regulatory protein | 0.0066 | 0.0082 | 0.0082 |
Echinococcus multilocularis | geminin | 0.019 | 0.0383 | 0.0383 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0091 | 0.0144 | 0.0144 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.171 | 0.4071 | 0.4071 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.4153 | 1 | 1 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.171 | 0.4071 | 0.4071 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4153 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0066 | 0.0082 | 0.5 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0066 | 0.0082 | 0.0082 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.0091 | 0.0144 | 0.0144 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | conserved hypothetical protein | 0.171 | 0.4071 | 0.8733 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.171 | 0.4071 | 0.4071 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0.0144 | 0.0135 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.4153 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.171 | 0.4071 | 0.4071 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1948 | 0.465 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0812 | 0.1893 | 0.1893 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0328 | 0.0328 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.0091 | 0.0144 | 0.0144 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.4153 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.4153 | 1 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Toxoplasma gondii | GAF domain-containing protein | 0.0066 | 0.0082 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.171 | 0.4071 | 0.4071 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.0328 | 0.0328 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1948 | 0.465 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.171 | 0.4071 | 0.4071 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DosT | 0.0066 | 0.0082 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0066 | 0.0082 | 0.5 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0812 | 0.1893 | 0.1893 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0091 | 0.0144 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0383 | 0.0383 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1948 | 0.465 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.0328 | 0.0328 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.4153 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.171 | 0.4071 | 0.4071 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0066 | 0.0082 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.171 | 0.4071 | 0.4071 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.171 | 0.4071 | 0.4071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 29 | In vitro inhibition of rat liver HMG-CoA reductase at concentration of 10e-3 M | ChEMBL. | 3989819 |
Inhibition (binding) | = 29 % | In vitro inhibition of rat liver HMG-CoA reductase at concentration of 10e-3 M | ChEMBL. | 3989819 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.