Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | p450 reductase, putative | 0.0496 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0307 | 0.2291 | 0.2291 |
Giardia lamblia | Hypothetical protein | 0.044 | 0.7709 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0496 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0496 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0496 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.044 | 0.7709 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0496 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0496 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0496 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0307 | 0.2291 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0496 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0496 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0496 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0496 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0496 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0496 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0496 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0496 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0496 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0496 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0496 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0496 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0496 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0496 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 13.9 | Estrogenic activity in mouse uterotrophic assay at 0 ug | ChEMBL. | 6325689 |
Activity (functional) | = 14.3 | Estrogenic activity in mouse uterotrophic assay at 0.1 ug | ChEMBL. | 6325689 |
Activity (functional) | = 14.8 | Anti-estrogenic activity in mouse uterotrophic assay at 0 ug | ChEMBL. | 6325689 |
Activity (functional) | = 21.7 | Estrogenic activity in mouse uterotrophic assay at 1 ug | ChEMBL. | 6325689 |
Activity (functional) | = 34.3 | Anti-estrogenic activity in mouse uterotrophic assay at 1 ug | ChEMBL. | 6325689 |
Activity (functional) | = 39.6 | Anti-estrogenic activity in mouse uterotrophic assay at 10 ug | ChEMBL. | 6325689 |
Activity (functional) | = 41.8 | Anti-estrogenic activity in mouse uterotrophic assay at 100 ug | ChEMBL. | 6325689 |
Activity (functional) | = 43.5 | Estrogenic activity in mouse uterotrophic assay at 1000 ug | ChEMBL. | 6325689 |
Activity (functional) | = 45 | Estrogenic activity in mouse uterotrophic assay at 10 ug | ChEMBL. | 6325689 |
Activity (functional) | = 46.2 | Estrogenic activity in mouse uterotrophic assay at 100 ug | ChEMBL. | 6325689 |
Inhibition (functional) | = 3 % | Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 10 mg/kg | ChEMBL. | 6325689 |
Inhibition (functional) | = 3 % | Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 10 mg/kg | ChEMBL. | 6325689 |
Inhibition (functional) | = 24 % | Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 1 mg/kg | ChEMBL. | 6325689 |
Inhibition (functional) | = 24 % | Anti-estrogenic activity as inhibition of estrone-stimulated uterine growth in mice at 1 mg/kg | ChEMBL. | 6325689 |
RBA (binding) | = 0.73 | Relative binding affinity for calf uterine estrogen receptor is the ratio of molar cencentrations of 17-beta-estradiol and compound required to decrease amount of bound [3H]-E2 by 50% X 100. | ChEMBL. | 6325689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.