Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0112 | 0.2048 | 0.8221 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.01 | 0.1684 | 0.6757 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0083 | 0.0331 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.01 | 0.1684 | 0.6757 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0126 | 0.2492 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0112 | 0.2048 | 0.8221 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.3459 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0112 | 0.2048 | 0.8221 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.3459 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0126 | 0.2492 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0126 | 0.2492 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0112 | 0.2048 | 0.8221 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.3459 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0112 | 0.2048 | 0.8221 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0126 | 0.2492 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.01 | 0.1684 | 0.6757 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.2165 | 0.8689 |
Loa Loa (eye worm) | thymidylate synthase | 0.0112 | 0.2048 | 0.9461 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.2165 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0083 | 0.0381 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0046 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0083 | 0.0331 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.2165 | 1 |
Brugia malayi | thymidylate synthase | 0.0112 | 0.2048 | 0.8221 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1684 | 0.7777 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0126 | 0.2492 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0053 | 0.0235 | 0.0943 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0158 | 0.3459 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0083 | 0.0381 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0235 | 0.0943 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.3459 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0112 | 0.2048 | 0.8221 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0126 | 0.2492 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0158 | 0.3459 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = -6 % | Hypolipidemic activity, expressed as percent decrease in serum cholesterol in rat, at dosage of 100 mg for 7 days by Zak et al method | ChEMBL. | 7359513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.