Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimalarial activity against Plasmodium berghei; Active | ChEMBL. | 6993681 | |
Activity (functional) | 0 | Antimalarial activity against Plasmodium berghei; Active | ChEMBL. | 6993681 |
IC50 (ADMET) | > 20.46 uM | Cytotoxicity against human PBMC cells after 72 hrs by Alamar Blue assay | ChEMBL. | 21115213 |
IC50 (functional) | > 20.46 uM | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 21115213 |
IC50 (functional) | > 20.46 uM | Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay | ChEMBL. | 21115213 |
IC50 (functional) | > 20.46 uM | Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay | ChEMBL. | 21115213 |
IC50 (functional) | = 20.46 uM | Cytotoxicity against human SF295 cells after 72 hrs by MTT assay | ChEMBL. | 21115213 |
IC50 (ADMET) | = 62.13 uM | Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay | ChEMBL. | 17249647 |
IC50 (ADMET) | = 62.13 uM | Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay | ChEMBL. | 17249647 |
IC50 (ADMET) | > 102.34 uM | Cytotoxicity against human PBMC after 72 hrs by Alamar blue assay | ChEMBL. | 21820768 |
logP (ADMET) | = 3.87 | Partition coefficient (logP) | ChEMBL. | 6993681 |
LogP | = 4.1 | Partition coefficient, log P of the compound | ChEMBL. | 17249647 |
MIC (functional) | = 205 uM | Antitubercular activity against rifampicin-resistant Mycobacterium tuberculosis ATCC 35338 harboring His-526-Tri mutation in rpoB gene after 9 days by resazurin reduction assay | ChEMBL. | 21820768 |
MIC (functional) | = 205 uM | Antitubercular activity against isoniazid-resistant Mycobacterium tuberculosis ATCC 35822 harboring Ser-315-Tri mutation in katG gene after 9 days by resazurin reduction assay | ChEMBL. | 21820768 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.