Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antihypertensive score (functional) | = 0 | Antihypertensive activity after po administration of 5 mg/kg dose in spontaneously hypertensive(SH) rats; score is for average value of two animals | ChEMBL. | 6834393 |
Antihypertensive score (functional) | = 2 | Antihypertensive activity after administration of 20 mg/kg dose in spontaneously hypertensive(SH) rats; score is for average value of two animals | ChEMBL. | 6834393 |
Saluretic score (functional) | = 2 | Saluretic property in an anesthetized dog after 5 mg/kg po administration; score is for average of two animals | ChEMBL. | 6834393 |
Saluretic score (functional) | = 4 | Saluretic property after administration in rats | ChEMBL. | 6834393 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.