Detailed information for compound 267759

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 567.077 | Formula: C25H33ClN5O6S-
  • H donors: 4 H acceptors: 5 LogP: 0.23 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C[C@@H]1ON([C@@H](C1)c1ccc(cc1)C(=N)N)C(C)C)NC[C@H](C(=O)O)NS(=O)(=O)c1cccc(c1)C.[Cl-]
  • InChi: 1S/C25H33N5O6S.ClH/c1-15(2)30-22(17-7-9-18(10-8-17)24(26)27)12-19(36-30)13-23(31)28-14-21(25(32)33)29-37(34,35)20-6-4-5-16(3)11-20;/h4-11,15,19,21-22,29H,12-14H2,1-3H3,(H3,26,27)(H,28,31)(H,32,33);1H/p-1/t19-,21-,22+;/m0./s1
  • InChiKey: HRDJIFWLTVRIOM-PQYKPJTCSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0022 0.0003 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.3039 0.3039
Treponema pallidum glutamate/aspartate transporter 0.0447 0.4307 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0184 0.3718
Loa Loa (eye worm) hypothetical protein 0.0029 0.0068 0.0068
Echinococcus multilocularis excitatory amino acid transporter 3 0.1008 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0003 0.0061
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Schistosoma mansoni hypothetical protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0149 0.1291 0.1291
Treponema pallidum glutamate transporter 0.0447 0.4307 1
Trichomonas vaginalis esterase, putative 0.0071 0.0495 1
Echinococcus granulosus excitatory amino acid transporter 3 0.1008 1 1
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Loa Loa (eye worm) excitatory amino acid transporter 0.1008 1 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0495 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0142 0.2865
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Mycobacterium ulcerans beta-lactamase 0.0071 0.0495 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0495 0.0495
Echinococcus multilocularis neutral amino acid transporter A 0.1008 1 1
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0022 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0184 0.3718
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0142 0.0142
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0495 1
Trichomonas vaginalis porcupine, putative 0.0022 0.0003 0.0061
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0003 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0495 0.0051
Trypanosoma brucei glucosidase, putative 0.0036 0.0142 0.2865
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0495 0.0051
Echinococcus granulosus neutral amino acid transporter 0.1008 1 1
Schistosoma mansoni importin beta-1 0.003 0.0081 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0184 0.0184
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0986 0.0986
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0003 0.0163
Echinococcus granulosus sodium:dicarboxylate symporter 0.1008 1 1
Schistosoma mansoni alpha-glucosidase 0.014 0.1198 0.1198
Schistosoma mansoni lamin 0.0029 0.0073 0.0073
Schistosoma mansoni sterol O-acyltransferase 1 0.023 0.2109 0.2109
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0447 0.9022
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1428 0.1428
Echinococcus granulosus lamin 0.0029 0.0073 0.0073
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0073
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0003 0.0163
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0073 0.0073
Echinococcus multilocularis Excitatory amino acid transporter 0.1008 1 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0003 0.0061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0495 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0081 0.0081
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0003 0.0061
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0447 0.4307 0.4307
Echinococcus multilocularis sterol O acyltransferase 1 0.023 0.2109 0.2109
Mycobacterium tuberculosis Conserved protein 0.0071 0.0495 0.0051
Schistosoma mansoni microtubule-associated protein tau 0.0753 0.741 0.741
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0003 0.0163
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0022 0.0003 0.0003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1428 0.1428
Echinococcus multilocularis muscleblind protein 0.0149 0.1291 0.1291
Toxoplasma gondii hypothetical protein 0.0022 0.0003 0.0061
Brugia malayi beta-lactamase 0.0071 0.0495 0.0495
Echinococcus multilocularis neutral amino acid transporter A 0.1008 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0495 1
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0022 0.0003 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Echinococcus granulosus Excitatory amino acid transporter 0.1008 1 1
Echinococcus granulosus microtubule associated protein 2 0.0753 0.741 0.741
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0142 0.0142
Brugia malayi intermediate filament protein 0.0029 0.0073 0.0073
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0495 0.0051
Echinococcus granulosus excitatory amino acid transporter 2 0.1008 1 1
Loa Loa (eye worm) hypothetical protein 0.0258 0.2391 0.2391
Brugia malayi MH2 domain containing protein 0.0119 0.0986 0.0986
Echinococcus granulosus neutral amino acid transporter A 0.1008 1 1
Schistosoma mansoni zinc finger protein 0.0022 0.0003 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.013 0.013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0309 0.0309
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0447 0.0447
Onchocerca volvulus 0.0053 0.0309 0.0306
Chlamydia trachomatis glutamate symporter 0.1008 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1428 0.1428
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0022 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1008 1 0.5
Leishmania major importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Trypanosoma cruzi GUP1, putative 0.0022 0.0003 0.0061
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0495 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0495 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0184 0.3718
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1008 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.2865
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0022 0.0003 0.0061
Brugia malayi hypothetical protein 0.0035 0.013 0.013
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0022 0.0003 0.0003
Onchocerca volvulus 0.0094 0.0731 0.0728
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Schistosoma mansoni hypothetical protein 0.0322 0.3039 0.3039
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0081 0.163
Echinococcus granulosus muscleblind protein 0.0149 0.1291 0.1291
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.013 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0022 0.0003 0.0373
Leishmania major hypothetical protein, conserved 0.0022 0.0003 0.0061
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0022 0.0003 0.0003
Echinococcus granulosus neutral amino acid transporter A 0.1008 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0495 1
Echinococcus granulosus lamin dm0 0.0029 0.0073 0.0073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0239 0.0239
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1008 1 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0003 0.0163
Schistosoma mansoni intermediate filament proteins 0.0029 0.0073 0.0073
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0184 0.3718
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0022 0.0003 0.0003
Schistosoma mansoni alpha-glucosidase 0.014 0.1198 0.1198
Echinococcus multilocularis lamin dm0 0.0029 0.0073 0.0073
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1008 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0073 0.0073
Onchocerca volvulus 0.0029 0.0073 0.007
Mycobacterium tuberculosis Conserved protein 0.0071 0.0495 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0495 1
Mycobacterium ulcerans hypothetical protein 0.0071 0.0495 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1008 1 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0022 0.0003 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.4376 0.4113
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0142 0.2865
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Echinococcus multilocularis importin subunit beta 1 0.003 0.0081 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0495 0.0495
Echinococcus granulosus excitatory amino acid transporter 2 0.1008 1 1
Echinococcus multilocularis lamin 0.0029 0.0073 0.0073
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0447 0.0447
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0495 0.0051
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0495 0.0051
Onchocerca volvulus 0.0071 0.0495 0.0492
Loa Loa (eye worm) hypothetical protein 0.004 0.0184 0.0184
Leishmania major hypothetical protein, conserved 0.0071 0.0495 1
Brugia malayi diacylglycerol acyltransferase 0.0022 0.0003 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0495 0.0495
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0073 0.0073
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.013 0.013
Schistosoma mansoni alpha glucosidase 0.0036 0.0142 0.0142
Echinococcus multilocularis snurportin 1 0.0322 0.3039 0.3039
Entamoeba histolytica hypothetical protein 0.0022 0.0003 0.0163
Loa Loa (eye worm) hhat protein 0.0022 0.0003 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0495 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.2125 0.2125
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0003
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0184 0.0184
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0142 0.7705
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0003 0.0003
Echinococcus granulosus intermediate filament protein 0.0029 0.0073 0.0073
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0462
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0142 0.2865
Schistosoma mansoni hypothetical protein 0.0035 0.013 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0239 0.0239
Brugia malayi hypothetical protein 0.0258 0.2391 0.2391
Echinococcus granulosus snurportin 1 0.0322 0.3039 0.3039
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0495 0.0051
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Brugia malayi Importin beta-1 subunit 0.003 0.0081 0.0081
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0184 0.0184
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0142 0.0142
Brugia malayi Hhat protein 0.0022 0.0003 0.0003
Brugia malayi RNA, U transporter 1 0.0086 0.0644 0.0644
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0184 0.0184
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1428 0.1428
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0022 0.0003 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0495 0.0051
Echinococcus multilocularis neutral amino acid transporter A 0.1008 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0142 0.2865
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1008 1 1
Loa Loa (eye worm) hhat protein 0.0022 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0003 0.0003
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0447 0.4307 0.4307
Echinococcus granulosus Excitatory amino acid transporter 0.1008 1 1
Loa Loa (eye worm) beta-lactamase 0.0071 0.0495 0.0495
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0495 0.0495
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0184 0.0184
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.023 0.2109 0.2109
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0023 0.0462
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0495 0.0495
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0003 0.0061
Mycobacterium leprae Probable lipase LipE 0.0071 0.0495 0.5
Echinococcus multilocularis Excitatory amino acid transporter 0.1008 1 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0022 0.0003 0.0003
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0239 0.0239
Schistosoma mansoni survival motor neuron protein 0.0053 0.0309 0.0309
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0184 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0447 0.0447
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0022 0.0003 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0142 0.2865
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Toxoplasma gondii ABC1 family protein 0.0071 0.0495 1
Trypanosoma cruzi GUP1, putative 0.0022 0.0003 0.0061
Trichomonas vaginalis transmembrane protein nessy, putative 0.0022 0.0003 0.0061
Plasmodium falciparum importin beta, putative 0.003 0.0081 1
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.2391 0.2391
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0003 0.0003
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0142 0.2865
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0184 0.3718
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0184 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0239 0.0239
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0003 0.0003
Entamoeba histolytica vacuolar protein sorting 26 0.0022 0.0003 0.0163
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0081 0.163
Mycobacterium tuberculosis Conserved protein 0.0071 0.0495 0.0051
Entamoeba histolytica hypothetical protein 0.0024 0.0023 0.1244
Entamoeba histolytica hypothetical protein 0.0035 0.013 0.7037
Loa Loa (eye worm) hypothetical protein 0.0149 0.1291 0.1291
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0003 0.0003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0184 0.3718
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0495 1
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1291 0.1291
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0986 0.0986
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0239 0.0239
Echinococcus multilocularis excitatory amino acid transporter 2 0.1008 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0447 0.0447
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0081 0.163
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0022 0.0003 0.0003
Echinococcus multilocularis microtubule associated protein 2 0.0753 0.741 0.741
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0239 0.0239
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0142 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0239 0.0239
Brugia malayi follicle stimulating hormone receptor 0.0232 0.2125 0.2125
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0142 0.2865
Onchocerca volvulus 0.0029 0.0073 0.007
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1428 0.1428
Echinococcus granulosus sterol O acyltransferase 1 0.023 0.2109 0.2109
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0022 0.0003 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0239 0.0239
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0003 0.0003
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1008 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0003 0.0061
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0447 0.4307 0.4307
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0022 0.0003 0.0003
Onchocerca volvulus 0.0071 0.0495 0.0492
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.2391 0.2391
Brugia malayi MBOAT family protein 0.0022 0.0003 0.0003
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis musashi 0.0029 0.0073 0.0073
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0142 0.7705
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0495 1
Onchocerca volvulus 0.0071 0.0495 0.0492
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0495 0.0495
Schistosoma mansoni hypothetical protein 0.0053 0.0309 0.0309
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0184 0.3718
Brugia malayi beta-lactamase family protein 0.0071 0.0495 0.0495
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0184 0.0184
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0184 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0495 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0003 0.0061
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0003 0.0003
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0022 0.0003 0.0061
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0022 0.0003 0.0061
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0447 0.9022
Loa Loa (eye worm) hypothetical protein 0.0208 0.1881 0.1881
Schistosoma mansoni lamin 0.0029 0.0073 0.0073
Brugia malayi beta-lactamase family protein 0.0071 0.0495 0.0495
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0184 0.0184
Plasmodium vivax importin-beta 2, putative 0.003 0.0081 0.163
Leishmania major glycerol uptake protein, putative 0.0022 0.0003 0.0061
Brugia malayi Muscleblind-like protein 0.0149 0.1291 0.1291
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0142 0.2865
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0495 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0447 0.4307 0.4307

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.14 uM Compound was tested for its invitro activity in the inhibition of platelet aggregation using human platelet rich plasma ChEMBL. 9990456

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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