Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Brugia malayi | ecdysteroid receptor | retinoid X receptor, gamma | 340 aa | 338 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.047 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0507 | 0.1003 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0802 | 0.8997 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0507 | 0.1003 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0802 | 0.8997 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | > 0.001 nM | Inhibition of [3H]-RA binding to retinoic acid receptor RAR alpha | ChEMBL. | 10098670 |
Kd (binding) | > 0.001 nM | Inhibition of [3H]-RA binding to retinoic acid receptor RAR beta | ChEMBL. | 10098670 |
Kd (binding) | > 0.001 nM | Inhibition of [3H]-RA binding to retinoic acid receptor RAR gamma | ChEMBL. | 10098670 |
Kd (binding) | > 0.001 nM | Inhibition of [3H]-RA binding to retinoic acid receptor RAR alpha | ChEMBL. | 10098670 |
Kd (binding) | > 0.001 nM | Inhibition of [3H]-RA binding to retinoic acid receptor RAR beta | ChEMBL. | 10098670 |
Kd (binding) | > 0.001 nM | Inhibition of [3H]-RA binding to retinoic acid receptor RAR gamma | ChEMBL. | 10098670 |
Kd (binding) | = 7 nM | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 10098670 |
Kd (binding) | = 7 nM | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 10098670 |
Kd (binding) | = 14 nM | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 10098670 |
Kd (binding) | = 14 nM | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma | ChEMBL. | 10098670 |
Kd (binding) | = 15 nM | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR beta | ChEMBL. | 10098670 |
Kd (binding) | = 15 nM | Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR beta | ChEMBL. | 10098670 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.