Detailed information for compound 267814

Basic information

Technical information
  • TDR Targets ID: 267814
  • Name: 2-[[4-[(3-chlorophenyl)methoxy]phenyl]methyla mino]-N,N-dimethylacetamide
  • MW: 332.825 | Formula: C18H21ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 2.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)COc1ccc(cc1)CNCC(=O)N(C)C
  • InChi: 1S/C18H21ClN2O2/c1-21(2)18(22)12-20-11-14-6-8-17(9-7-14)23-13-15-4-3-5-16(19)10-15/h3-10,20H,11-13H2,1-2H3
  • InChiKey: KADDGKUAPKGHIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-[(3-chlorophenyl)methoxy]phenyl]methylamino]-N,N-dimethyl-acetamide
  • 2-[[4-[(3-chlorophenyl)methoxy]phenyl]methylamino]-N,N-dimethyl-ethanamide
  • 2-[[4-(3-chlorobenzyl)oxybenzyl]amino]-N,N-dimethyl-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Echinococcus granulosus voltage gated potassium channel subunit 0.003 0.137 0.2152
Schistosoma mansoni pol-related 0.0103 0.6363 0.6363
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.1036 0.1628
Echinococcus granulosus multidrug resistance protein 1 0.0025 0.1036 0.1628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Brugia malayi Cathepsin L-like precursor 0.0019 0.0627 0.0986
Loa Loa (eye worm) hypothetical protein 0.006 0.3427 0.5383
Schistosoma mansoni aldo-keto reductase 0.0103 0.6363 0.6363
Echinococcus multilocularis multidrug resistance protein 1 0.0025 0.1036 0.1628
Plasmodium falciparum ABC transporter B family member 5, putative 0.0017 0.0476 0.3477
Echinococcus multilocularis ATP binding cassette sub family B 0.0017 0.0476 0.0748
Entamoeba histolytica hypothetical protein 0.006 0.3427 0.5387
Echinococcus granulosus aldo keto reductase 0.0103 0.6363 1
Echinococcus granulosus multidrug resistance protein 1 0.0025 0.1036 0.1628
Schistosoma mansoni multidrug resistance protein 0.006 0.3427 0.3427
Brugia malayi ABC transporter family protein 0.0017 0.0476 0.0748
Brugia malayi Cathepsin L-like precursor 0.0013 0.02 0.0314
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0017 0.0476 0.0476
Echinococcus granulosus ATP binding cassette sub family B 0.0017 0.0476 0.0748
Plasmodium vivax ABC transporter B family member 6, putative 0.0017 0.0476 0.3477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Brugia malayi Cathepsin L-like precursor 0.0019 0.0627 0.0986
Onchocerca volvulus 0.0103 0.6363 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0017 0.0476 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.1036 0.1628
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.006 0.3427 0.5387
Schistosoma mansoni ABC transporter 0.001 0.0005 0.0005
Onchocerca volvulus 0.0025 0.1036 0.1357
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0017 0.0476 0.0748
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.006 0.3427 0.5297
Echinococcus multilocularis aldo keto reductase 0.0103 0.6363 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.1036 0.1628
Plasmodium falciparum ABC transporter B family member 6, putative 0.0017 0.0476 0.3477
Brugia malayi P-glycoprotein-like protein 0.0017 0.0476 0.0748
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.1036 0.1628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Echinococcus granulosus multidrug resistance associated protein 7 0.006 0.3427 0.5387
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.3209 0.5042
Trichomonas vaginalis abcb9, putative 0.0025 0.1036 0.1628
Echinococcus multilocularis aldo keto reductase 0.0103 0.6363 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0627 0.4581
Echinococcus multilocularis multidrug resistance associated protein 1 0.006 0.3427 0.5387
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.006 0.3427 0.5297
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.1036 0.1628
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Leishmania major prostaglandin f synthase, putative 0.0103 0.6363 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0103 0.6363 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.003 0.137 0.2152
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0025 0.1036 0.1628
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0017 0.0476 0.0569
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.1036 0.1628
Brugia malayi ABC transporter family protein 0.001 0.0005 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0476 0.0569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0476 0.0569
Trypanosoma brucei ABC transporter, putative 0.0012 0.0121 0.0121
Onchocerca volvulus 0.0103 0.6363 1
Mycobacterium tuberculosis Conserved protein 0.003 0.137 0.1518
Brugia malayi Cathepsin L-like precursor 0.0019 0.0627 0.0986
Schistosoma mansoni multidrug resistance protein 0.0025 0.1036 0.1036
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0441 0.0693
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.003 0.137 0.2
Leishmania major cathepsin L-like protease 0.0019 0.0627 0.0812
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0627 0.0627
Plasmodium falciparum ABC transporter B family member 3, putative 0.0017 0.0476 0.3477
Trypanosoma cruzi hypothetical protein 0.0043 0.2285 0.359
Trichomonas vaginalis abcb9, putative 0.0025 0.1036 0.1628
Onchocerca volvulus 0.0103 0.6363 1
Echinococcus multilocularis aldehyde reductase 0.0073 0.4327 0.68
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0017 0.0476 0.3477
Schistosoma mansoni multidrug resistance protein 0.0016 0.0441 0.0441
Entamoeba histolytica P-glycoprotein 5, putative 0.0025 0.1036 0.1628
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Plasmodium falciparum ABC transporter G family member 2 0.0012 0.0121 0.0882
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0017 0.0476 0.3477
Plasmodium falciparum multidrug resistance protein 1 0.0025 0.1036 0.7566
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.3836 0.6029
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0627 0.0986
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.1036 0.1628
Plasmodium vivax ABC transporter B family member 3, putative 0.0017 0.0476 0.3477
Trichomonas vaginalis abcb9, putative 0.0025 0.1036 0.1628
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Echinococcus multilocularis cysteine protease 0.0019 0.0627 0.0986
Echinococcus multilocularis ATP binding cassette sub family B 0.0017 0.0476 0.0748
Onchocerca volvulus 0.0019 0.0627 0.0694
Onchocerca volvulus 0.0019 0.0627 0.0694
Echinococcus multilocularis voltage gated potassium channel subunit 0.003 0.137 0.2152
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.1036 0.1628
Plasmodium vivax ABC transporter G family member 2, putative 0.0012 0.0121 0.0882
Echinococcus granulosus multidrug resistance associated protein 1 0.006 0.3427 0.5387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Schistosoma mansoni smdr1 0.0017 0.0476 0.0476
Echinococcus multilocularis cysteine protease 0.0019 0.0627 0.0986
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0121 0.019
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0025 0.1036 0.1466
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Loa Loa (eye worm) ABC transporter 0.0017 0.0476 0.0741
Giardia lamblia MRP-like ABC transporter 0.006 0.3427 0.5324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Brugia malayi ABC transporter family protein 0.0025 0.1036 0.1628
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.006 0.3427 0.5387
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0121 0.019
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.003 0.137 1
Schistosoma mansoni aldo-keto reductase 0.0103 0.6363 0.6363
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0627 0.0986
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.6363 1
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0121 0.019
Giardia lamblia Multidrug resistance-associated protein 1 0.006 0.3427 0.5324
Loa Loa (eye worm) cysteine protease 0.0019 0.0627 0.0979
Entamoeba histolytica P-glycoprotein-2, putative 0.0016 0.0441 0.0693
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0627 0.0694
Trypanosoma brucei aldo-keto reductase, putative 0.0103 0.6363 0.6363
Entamoeba histolytica aldose reductase, putative 0.0103 0.6363 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.1036 0.1628
Toxoplasma gondii aldose reductase, putative 0.0103 0.6363 1
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0017 0.0476 0.0476
Plasmodium falciparum multidrug resistance-associated protein 2 0.0017 0.0476 0.3477
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.4264 0.6701
Loa Loa (eye worm) oxidoreductase 0.0103 0.6363 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.1036 0.1466
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0017 0.0476 0.5
Brugia malayi multidrug resistance protein 3 0.0025 0.1036 0.1628
Onchocerca volvulus 0.0019 0.0627 0.0694
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0627 0.0986
Entamoeba histolytica P-glyco protein 6, putative 0.0025 0.1036 0.1628
Echinococcus granulosus cathepsin l1 0.0013 0.02 0.0314
Trypanosoma brucei multidrug resistance-associated protein, putative 0.006 0.3427 0.3427
Leishmania major cathepsin L-like protease 0.0019 0.0627 0.0812
Loa Loa (eye worm) hypothetical protein 0.0025 0.1036 0.1622
Echinococcus granulosus aldo keto reductase family 1, member B4 0.003 0.137 0.2152
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.137 0.2152
Brugia malayi Cathepsin L-like precursor 0.0019 0.0627 0.0986
Leishmania major cathepsin L-like protease 0.0072 0.4264 0.6637
Toxoplasma gondii ABC transporter family protein 0.0017 0.0476 0.0569
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Giardia lamblia Hypothetical protein 0.0016 0.0441 0.0566
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Brugia malayi ABC transporter transmembrane region family protein 0.0016 0.0441 0.0693
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0627 0.0694
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.003 0.137 0.2
Echinococcus granulosus ATP binding cassette sub family B 0.0017 0.0476 0.0748
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.1036 0.1628
Brugia malayi Cathepsin L-like precursor 0.0019 0.0627 0.0986
Trichomonas vaginalis ABC transporter, putative 0.0025 0.1036 0.1628
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0017 0.0476 0.0569
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0017 0.0476 0.0569
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0016 0.0441 0.0693
Plasmodium vivax multidrug resistance protein 2, putative 0.0017 0.0476 0.3477
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.1036 0.1628
Onchocerca volvulus 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Brugia malayi Cathepsin L-like precursor 0.0019 0.0627 0.0986
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.02 0.0314
Trypanosoma brucei multidrug resistance-associated protein, putative 0.006 0.3427 0.3427
Onchocerca volvulus 0.0103 0.6363 1
Onchocerca volvulus 0.0019 0.0627 0.0694
Entamoeba histolytica ATP-binding cassette protein, putative 0.006 0.3427 0.5387
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.1036 0.1628
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Leishmania major pentamidine resistance protein 1 0.006 0.3427 0.5297
Loa Loa (eye worm) hypothetical protein 0.0013 0.02 0.0306
Echinococcus multilocularis aldo keto reductase 0.0103 0.6363 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.1036 0.1628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.1036 0.1628
Plasmodium falciparum multidrug resistance-associated protein 1 0.0017 0.0476 0.3477
Brugia malayi ABC transporter 0.0016 0.0441 0.0693
Echinococcus multilocularis 0.0017 0.0476 0.0748
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0012 0.0121 0.019
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0121 0.0121
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Plasmodium falciparum ABC transporter B family member 4, putative 0.0017 0.0476 0.3477
Loa Loa (eye worm) hypothetical protein 0.0025 0.1036 0.1622
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0476 0.0569
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0103 0.6363 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0627 0.0627
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.1036 0.1628
Brugia malayi multidrug resistance related protein 1 0.006 0.3427 0.5387
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.1036 0.1628
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0103 0.6363 1
Echinococcus granulosus ATP binding cassette sub family B 0.0016 0.0441 0.0693
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Brugia malayi ABC transporter transmembrane region family protein 0.0017 0.0476 0.0748
Entamoeba histolytica P-glycoprotein-5 0.0025 0.1036 0.1628
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0025 0.1036 0.1628
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0627 0.0812
Toxoplasma gondii ABC transporter, putative 0.0017 0.0476 0.0569
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.006 0.3427 0.5297
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Entamoeba histolytica ABC transporter, putative 0.0012 0.0121 0.019
Giardia lamblia ABC transporter, putative 0.006 0.3427 0.5324
Loa Loa (eye worm) hypothetical protein 0.006 0.3427 0.5383
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0103 0.6363 1
Trichomonas vaginalis ABC transporter, putative 0.0025 0.1036 0.1628
Brugia malayi Cathepsin L-like precursor 0.0013 0.02 0.0314
Brugia malayi ABC transporter 0.0017 0.0476 0.0748
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0627 0.0986
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0016 0.0441 0.0441
Loa Loa (eye worm) ABC transporter 0.0017 0.0476 0.0741
Leishmania major p-glycoprotein 0.0025 0.1036 0.1466
Plasmodium vivax vivapain-2 0.0019 0.0627 0.4581
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.1001 0.1572
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Entamoeba histolytica ATP-binding cassette protein, putative 0.006 0.3427 0.5387
Trypanosoma brucei RNA helicase, putative 0.0157 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0103 0.6363 1
Trypanosoma brucei multidrug resistance protein E 0.006 0.3427 0.3427
Leishmania major cathepsin L-like protease 0.0019 0.0627 0.0812
Echinococcus multilocularis multidrug resistance associated protein 7 0.006 0.3427 0.5387
Echinococcus granulosus cathepsin l1 0.0019 0.0627 0.0986
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.1036 0.1628
Onchocerca volvulus 0.0019 0.0627 0.0694
Echinococcus multilocularis multidrug resistance protein 1 0.0025 0.1036 0.1628
Trypanosoma cruzi multidrug resistance protein E, putative 0.006 0.3427 0.5387
Loa Loa (eye worm) hypothetical protein 0.006 0.3392 0.5327
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Plasmodium falciparum aldo-keto reductase, putative 0.003 0.137 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.1036 0.1628
Loa Loa (eye worm) hypothetical protein 0.0019 0.0627 0.0979
Entamoeba histolytica cysteine protease, putative 0.0019 0.0627 0.0986
Trichomonas vaginalis ABC transporter, putative 0.0025 0.1036 0.1628
Echinococcus multilocularis ATP binding cassette sub family B 0.0017 0.0476 0.0748
Giardia lamblia Aldose reductase 0.0103 0.6363 1
Leishmania major cathepsin L-like protease 0.0019 0.0627 0.0812
Trypanosoma cruzi aldo/keto reductase, putative 0.003 0.137 0.2152
Brugia malayi ABC transporter transmembrane region family protein 0.006 0.3427 0.5387
Loa Loa (eye worm) hypothetical protein 0.0017 0.0476 0.0741
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0017 0.0476 0.0569
Loa Loa (eye worm) hypothetical protein 0.0024 0.1001 0.1566
Schistosoma mansoni multidrug resistance protein 0.006 0.3427 0.3427
Onchocerca volvulus 0.003 0.137 0.1898
Plasmodium vivax vivapain-2 0.0019 0.0627 0.4581
Loa Loa (eye worm) oxidoreductase 0.0103 0.6363 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0627 0.0986
Loa Loa (eye worm) oxidoreductase 0.0103 0.6363 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.006 0.3427 0.5383
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0627 0.0986
Entamoeba histolytica ABC transporter, putative 0.006 0.3427 0.5387
Entamoeba histolytica ATP-binding cassette protein, putative 0.006 0.3427 0.5387
Brugia malayi hypothetical protein 0.0017 0.0476 0.0748
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0025 0.1036 0.1466
Schistosoma mansoni multidrug resistance protein 0.006 0.3427 0.3427
Plasmodium vivax multidrug resistance protein 1, putative 0.0025 0.1036 0.7566
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.02 0.02
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0103 0.6363 1
Giardia lamblia Multidrug resistance-associated protein 1 0.006 0.3427 0.5324
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0627 0.0986
Plasmodium vivax ABC transporter B family member 4, putative 0.0017 0.0476 0.3477
Loa Loa (eye worm) oxidoreductase 0.0103 0.6363 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0476 0.0569
Leishmania major cathepsin L-like protease 0.0072 0.4264 0.6637
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0016 0.0441 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Trypanosoma cruzi aldo/keto reductase, putative 0.0103 0.6363 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.006 0.3427 0.5387
Plasmodium falciparum aldehyde reductase, putative 0.003 0.137 1
Onchocerca volvulus 0.0103 0.6363 1
Schistosoma mansoni potassium channel beta 0.003 0.137 0.137
Plasmodium vivax ABC transporter B family member 5, putative 0.0017 0.0476 0.3477
Trichomonas vaginalis conserved hypothetical protein 0.003 0.137 0.2152
Entamoeba histolytica P-glycoprotein-1 0.0025 0.1036 0.1628
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.137 0.2152
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0441 0.0693
Mycobacterium ulcerans hypothetical protein 0.003 0.137 0.2
Plasmodium vivax aldehyde reductase, putative 0.003 0.137 1
Loa Loa (eye worm) fibroinase 0.0019 0.0627 0.0979
Entamoeba histolytica P-glycoprotein-2 0.0025 0.1036 0.1628
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0627 0.0986
Entamoeba histolytica P-glycoprotein 6, putative 0.0017 0.0476 0.0748
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Trypanosoma cruzi aldo-keto reductase 0.0103 0.6363 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Schistosoma mansoni multidrug resistance protein 0.0025 0.1036 0.1036
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Trypanosoma brucei prostaglandin f synthase 0.0103 0.6363 0.6363
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.006 0.3427 0.5297
Entamoeba histolytica P-glycoprotein-2 0.0025 0.1036 0.1628
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0016 0.0441 0.0693
Echinococcus granulosus multidrug resistance protein 1 0.0025 0.1036 0.1628
Trichomonas vaginalis aldo-keto reductase, putative 0.003 0.137 0.2152
Trichomonas vaginalis aldo/keto reductase, putative 0.0103 0.6363 1
Trypanosoma brucei ATP-binding cassette protein, putative 0.0012 0.0121 0.0121
Giardia lamblia Aldose reductase 0.0103 0.6363 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.003 0.137 0.2152
Mycobacterium ulcerans oxidoreductase 0.0103 0.6363 1
Trichomonas vaginalis ABC transporter, putative 0.0025 0.1036 0.1628
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.003 0.137 0.2
Echinococcus multilocularis multidrug resistance associated protein 4 0.0043 0.2285 0.359
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0627 0.4581
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0627 0.0986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Schistosoma mansoni multidrug resistance protein 0.006 0.3427 0.3427
Leishmania major cathepsin L-like protease 0.0072 0.4264 0.6637
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0627 0.0986
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0121 0.019
Trypanosoma cruzi ABC transporter, putative 0.0012 0.0121 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Plasmodium vivax ABC transporter B family member 7, putative 0.0017 0.0476 0.3477
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0627 0.0986
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.003 0.137 0.2146
Toxoplasma gondii aldo-keto reductase 0.003 0.137 0.2
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.003 0.137 0.2152
Loa Loa (eye worm) hypothetical protein 0.0103 0.6363 1
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.006 0.3427 0.5297
Entamoeba histolytica P-glycoprotein 6, putative 0.0017 0.0476 0.0748
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.0476 0.0569
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.4264 0.6701
Echinococcus granulosus aldehyde reductase 0.0073 0.4327 0.68
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.02 0.0314
Echinococcus granulosus multidrug resistance associated protein 4 0.0043 0.2285 0.359
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.1036 0.1628
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0121 0.019
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.1001 0.1572
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0017 0.0476 0.0569
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.1036 0.1628
Trypanosoma brucei p-glycoprotein 0.006 0.3427 0.3427
Echinococcus granulosus hypothetical protein 0.0103 0.6363 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.02 0.0306
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0025 0.1036 0.0951
Toxoplasma gondii cathepsin CPL 0.0019 0.0627 0.0812
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.4264 0.6701
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.02 0.0314
Loa Loa (eye worm) hypothetical protein 0.0013 0.02 0.0306
Schistosoma mansoni multidrug resistance protein 0.0025 0.1036 0.1036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Brugia malayi ABC transporter family protein 0.0017 0.0476 0.0748
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0627 0.0986
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Mycobacterium leprae Conserved hypothetical protein 0.0073 0.4327 0.6541
Brugia malayi ABC transporter family protein 0.0017 0.0476 0.0748
Entamoeba histolytica aldose reductase, putative 0.0103 0.6363 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0627 0.0694
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0627 0.0979
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0017 0.0476 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.006 0.3392 0.5267
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0103 0.6363 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0627 0.0986
Plasmodium falciparum ABC transporter B family member 7, putative 0.0017 0.0476 0.3477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0627 0.0986
Echinococcus granulosus aldo keto reductase 0.0103 0.6363 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0441 0.0685
Loa Loa (eye worm) ctsf protein 0.0019 0.0627 0.0979
Plasmodium falciparum multidrug resistance protein 2 0.0017 0.0476 0.3477
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0025 0.1036 0.1622
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0103 0.6363 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0017 0.0476 0.0569
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0627 0.4581
Entamoeba histolytica multidrug resistance protein, putative 0.006 0.3427 0.5387
Entamoeba histolytica aldose reductase, putative 0.0103 0.6363 1
Trypanosoma brucei aldo/keto reductase, putative 0.003 0.137 0.137
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0017 0.0476 0.0476
Onchocerca volvulus 0.0019 0.0627 0.0694
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0103 0.6363 1
Schistosoma mansoni multidrug resistance protein 0.0017 0.0476 0.0476
Trichomonas vaginalis taga, putative 0.0025 0.1036 0.1628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.02 0.0314
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.0476 0.0748
Echinococcus multilocularis aldo keto reductase 0.0103 0.6363 1
Loa Loa (eye worm) oxidoreductase 0.0103 0.6363 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0103 0.6363 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0025 0.1036 0.1622
Echinococcus multilocularis ATP binding cassette sub family B 0.0017 0.0476 0.0748
Entamoeba histolytica P-glycoprotein-2, putative 0.0025 0.1036 0.1628
Leishmania major aldo-keto reductase-like protein 0.0103 0.6363 1
Mycobacterium leprae Possible oxidoreductase 0.003 0.137 0.1518
Entamoeba histolytica P-glycoprotein 5, putative 0.0016 0.0441 0.0693
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.1036 0.1628
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0017 0.0476 0.0569
Brugia malayi glutamate-cysteine ligase modifier subunit 0.003 0.137 0.2152
Leishmania major cathepsin L-like protease 0.0019 0.0627 0.0812
Echinococcus granulosus aldo keto reductase 0.0103 0.6363 1
Loa Loa (eye worm) multidrug resistance-associated protein 0.0044 0.232 0.3641
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0103 0.6363 1
Onchocerca volvulus 0.0019 0.0627 0.0694
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0017 0.0476 0.0748
Trichomonas vaginalis aldo-keto reductase, putative 0.0103 0.6363 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0103 0.6363 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0121 0.019
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0017 0.0476 0.0748
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.1036 0.1628
Brugia malayi NADH-dependent xylose reductase 0.003 0.137 0.2152
Brugia malayi cathepsin L-like precursor 0.0013 0.02 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.4264 0.4264
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0627 0.0979
Schistosoma mansoni smdr2 0.0025 0.1036 0.1036
Loa Loa (eye worm) ABC transporter 0.0017 0.0476 0.0741
Leishmania major ABC-thiol transporter 0.006 0.3427 0.5297
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0017 0.0476 0.0569
Leishmania major p-glycoprotein e 0.006 0.3427 0.5297
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0025 0.1036 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.4264 0.6701
Trichomonas vaginalis aldo/keto reductase, putative 0.0103 0.6363 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 54.2 mg kg-1 Compound was tested for anticonvulsant potency using the intravenous-BIC (bicuculline) test in mice; compound at 200 mg/kg induced impaired gait, loss of the righting reflex, and impaired breathing ChEMBL. 9484507
ED50 (functional) = 54.2 mg kg-1 Compound was tested for anticonvulsant potency using the intravenous-BIC (bicuculline) test in mice; compound at 200 mg/kg induced impaired gait, loss of the righting reflex, and impaired breathing ChEMBL. 9484507

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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