Detailed information for compound 267913

Basic information

Technical information
  • TDR Targets ID: 267913
  • Name: (2S)-3-[[1-[3-(pyridin-2-ylamino)propyl]indaz ole-5-carbonyl]amino]-2-[(2,4,6-trimethylphen yl)sulfonylamino]propanoic acid
  • MW: 564.656 | Formula: C28H32N6O5S
  • H donors: 4 H acceptors: 7 LogP: 3.47 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H](NS(=O)(=O)c1c(C)cc(cc1C)C)CNC(=O)c1ccc2c(c1)cnn2CCCNc1ccccn1
  • InChi: 1S/C28H32N6O5S/c1-18-13-19(2)26(20(3)14-18)40(38,39)33-23(28(36)37)17-31-27(35)21-8-9-24-22(15-21)16-32-34(24)12-6-11-30-25-7-4-5-10-29-25/h4-5,7-10,13-16,23,33H,6,11-12,17H2,1-3H3,(H,29,30)(H,31,35)(H,36,37)/t23-/m0/s1
  • InChiKey: BDSVWPXYUWYWIQ-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-3-[[1-[3-(2-pyridylamino)propyl]indazole-5-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid
  • (2S)-3-[[oxo-[1-[3-(2-pyridylamino)propyl]-5-indazolyl]methyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid
  • (2S)-3-[[1-[3-(pyridin-2-ylamino)propyl]indazol-5-yl]carbonylamino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid
  • (2S)-2-(mesitylsulfonylamino)-3-[[1-[3-(2-pyridylamino)propyl]indazole-5-carbonyl]amino]propionic acid
  • (2S)-3-[[1-[3-(2-pyridylamino)propyl]indazole-5-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Starlite/ChEMBL References
Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing Get druggable targets OG5_129341 All targets in OG5_129341
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Brugia malayi Integrin alpha pat-2 precursor Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin alpha pat-2 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06476 integrin alpha 2B, putative Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma mansoni integrin alpha Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus multilocularis integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus granulosus integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0353 0.1877 1
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0658 0.3593 0.9493
Brugia malayi BRCA2 repeat family protein 0.014 0.0682 0.1802
Treponema pallidum leucyl-tRNA synthetase 0.0056 0.0212 0.1111
Schistosoma mansoni hypothetical protein 0.0313 0.1653 0.2443
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.003 0.0063 0.0093
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0796 0.4366 0.6452
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0019 0.0002 0.0003
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0023
Loa Loa (eye worm) integrin alpha pat-2 0.0285 0.1496 0.3952
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.003 0.0063 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0000014378 0.0000081679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Trichomonas vaginalis bsu-protein phosphatase, putative 0.003 0.0063 0.0166
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.003 0.0063 0.0063
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.0011
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0034 0.0089 0.0634
Schistosoma mansoni ran 0.0021 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0212 0.0561
Echinococcus granulosus importin subunit beta 1 0.0028 0.0055 0.0081
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0 0.0001
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0019 0.0002 0.0002
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0034 0.0089 0.4058
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0692 0.3784 0.5592
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0004 0.0006
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0056 0.0212 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0412 0.234
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0039 0.0039
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0619 0.3376 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0222 0.0586
Mycobacterium ulcerans hypothetical protein 0.004 0.0122 0.5666
Schistosoma mansoni elongation factor 1-gamma 0.0019 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0056 0.0212 0.0561
Plasmodium vivax aspartate--tRNA ligase, putative 0.0034 0.0089 0.0493
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0000014378 0.0000037992
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0089 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Loa Loa (eye worm) apoptosis regulator protein 0.0142 0.0694 0.1833
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.003 0.0063 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.003 0.0063 0.0063
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.003 0.0063 0.1351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0012
Loa Loa (eye worm) 63kd antigen 0.0034 0.0089 0.0234
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0000014378 0.0000081679
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0048 0.026
Loa Loa (eye worm) BRCA2 repeat family protein 0.014 0.0682 0.1802
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0048 0.026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0279 0.1461 0.3862
Leishmania major replication factor A, 51kDa subunit, putative 0.0332 0.176 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0322
Brugia malayi beta-lactamase 0.004 0.0122 0.0322
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0034 0.0089 0.4058
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0019 0.0002 0.0011
Schistosoma mansoni replication factor A 1 rfa1 0.0692 0.3784 0.5592
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0122 0.0885
Schistosoma mansoni leucyl-tRNA synthetase 0.0056 0.0212 0.0313
Onchocerca volvulus 0.004 0.0122 0.0356
Echinococcus multilocularis integrin alpha ps 0.0083 0.0362 0.0362
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0182 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0412 0.0609
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0000014378 0.0000081679
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Schistosoma mansoni methionine-tRNA synthetase 0.0353 0.1877 0.2773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0000014378 0.0000081679
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0692 0.3784 0.3784
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0000014378 0.0000081679
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0332 0.176 0.4651
Schistosoma mansoni hypothetical protein 0.0142 0.0694 0.1025
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0056 0.0212 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0055 0.0313
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.003 0.0063 0.0063
Echinococcus granulosus glycyl tRNA synthetase 0.0274 0.1435 0.212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Schistosoma mansoni integrin beta subunit 0.0223 0.1148 0.1696
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.003 0.0063 0.0166
Loa Loa (eye worm) hypothetical protein 0.0142 0.0694 0.1833
Brugia malayi replication factor A 73 kDa subunit 0.0692 0.3784 1
Brugia malayi glycyl-tRNA synthetase 0.0274 0.1435 0.3791
Echinococcus multilocularis integrin alpha ps 0.0083 0.0362 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Echinococcus multilocularis integrin beta 2 0.028 0.1471 0.1471
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0174 0.0874 0.4963
Brugia malayi methionyl-tRNA synthetase 0.0353 0.1877 0.496
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Brugia malayi mbt repeat family protein 0.0051 0.0182 0.0481
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0034 0.0089 0.0234
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0142 0.0694 0.1025
Echinococcus granulosus integrin alpha ps 0.004 0.012 0.0177
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0000014378 0.0000076603
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0126
Trichomonas vaginalis esterase, putative 0.004 0.0122 0.0322
Brugia malayi Aspartyl-tRNA synthetase 0.0034 0.0089 0.0234
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0000014378 0.0000081679
Mycobacterium leprae Probable lipase LipE 0.004 0.0122 0.2706
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0019 0.0002 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0122 0.0322
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.003 0.0063 0.0166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0241 0.1252 0.185
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0182 0.0182
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0000014378 0.0000081679
Plasmodium falciparum asparagine--tRNA ligase 0.0034 0.0089 0.0493
Loa Loa (eye worm) hypothetical protein 0.0145 0.0711 0.1879
Loa Loa (eye worm) hypothetical protein 0.0353 0.1877 0.496
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Plasmodium vivax replication protein A1, large subunit, putative 0.0332 0.176 1
Trichomonas vaginalis bsu-protein phosphatase, putative 0.003 0.0063 0.0166
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0322
Chlamydia trachomatis methionine--tRNA ligase 0.0353 0.1877 1
Leishmania major GTP-binding protein, putative 0.0021 0.0013 0.0075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0122 0.0885
Echinococcus granulosus stringent starvation protein A 0.0019 0.0002 0.0003
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0019 0.0002 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.1043 0.1541
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0122 0.0885
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0011
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0034 0.0089 0.0089
Trichomonas vaginalis protein phosphatase-1, putative 0.003 0.0063 0.0166
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0322
Plasmodium vivax methionine--tRNA ligase, putative 0.0056 0.0212 0.1195
Loa Loa (eye worm) CXXC zinc finger family protein 0.0114 0.0536 0.1416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Toxoplasma gondii lysine-tRNA ligase 0.0034 0.0089 0.0503
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0055 0.0313
Trichomonas vaginalis bsu-protein phosphatase, putative 0.003 0.0063 0.0166
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0412 0.1088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0005
Onchocerca volvulus 0.0114 0.0536 0.1582
Leishmania major asparaginyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0019 0.0002 0.0005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0122 0.0885
Schistosoma mansoni importin beta-1 0.0028 0.0055 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.011
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0692 0.3784 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0122 0.0885
Brugia malayi Importin beta-1 subunit 0.0028 0.0055 0.0145
Loa Loa (eye worm) beta-lactamase 0.004 0.0122 0.0322
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0182 0.0481
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0006
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0004 0.0088
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Schistosoma mansoni hypothetical protein 0.0301 0.1586 0.2343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0000014378 0.0000081679
Schistosoma mansoni protein phosphatase-1 0.003 0.0063 0.0093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0000014378 0.0000037992
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0048 0.0271
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0055 0.0055
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0034 0.0089 0.4058
Echinococcus granulosus glutathione S transferase 0.0019 0.0002 0.0003
Trypanosoma brucei protein phosphatase 1, putative 0.003 0.0063 0.0357
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0064
Toxoplasma gondii elongation factor 1-gamma, putative 0.0019 0.0002 0.0011
Echinococcus multilocularis geminin 0.0164 0.0821 0.0821
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0412 0.2194
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0182 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Leishmania major hypothetical protein, conserved 0.004 0.0122 0.0693
Brugia malayi protein ZK524.3 0.0056 0.0212 0.0561
Plasmodium falciparum aspartate--tRNA ligase 0.0034 0.0089 0.0493
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0013 0.0064
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0296 0.1562 0.4126
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0182 0.0269
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0122 0.0322
Treponema pallidum aspartyl-tRNA synthetase 0.0034 0.0089 0.0451
Leishmania major elongation factor-1 gamma 0.0019 0.0002 0.0011
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0039 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.003 0.0063 0.0166
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0056 0.0212 0.1563
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0095 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0122 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.1461 0.1461
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0039 0.0219
Schistosoma mansoni hypothetical protein 0.0034 0.0089 0.0131
Onchocerca volvulus 0.0051 0.0182 0.0534
Schistosoma mansoni ran 0.0021 0.0013 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0004 0.0011
Schistosoma mansoni hypothetical protein 0.1223 0.6768 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0025 0.0143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0004 0.0104
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0000014378 0.0000037992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Echinococcus multilocularis lysyl tRNA synthetase 0.0034 0.0089 0.0089
Leishmania major aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0122 0.0693
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0222 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.003 0.0063 0.0093
Plasmodium falciparum nucleic acid binding protein, putative 0.0034 0.0089 0.0493
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0412 0.0412
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0152 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Schistosoma mansoni kinase 0.0047 0.0159 0.0234
Mycobacterium leprae conserved hypothetical protein 0.004 0.0122 0.2706
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0048 0.0271
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0056 0.0212 0.0561
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.011
Brugia malayi mbt repeat family protein 0.0051 0.0182 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0039 0.0102
Echinococcus multilocularis integrin alpha 3 0.0142 0.0692 0.0692
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.004 0.012 0.0177
Plasmodium vivax importin-beta 2, putative 0.0028 0.0055 0.0302
Mycobacterium tuberculosis Conserved protein 0.004 0.0122 0.0885
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0000014378 0.0000037992
Trichomonas vaginalis helicase, putative 0.0026 0.0042 0.011
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.003 0.0063 0.0347
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0182 0.0269
Echinococcus multilocularis methionine tRNA synthetase 0.0056 0.0212 0.0212
Toxoplasma gondii aspartate-tRNA ligase 0.0034 0.0089 0.0503
Loa Loa (eye worm) MBCTL1 0.0058 0.0222 0.0586
Brugia malayi RNA, U transporter 1 0.008 0.0347 0.0916
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0222 0.0222
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0056 0.0056
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.003 0.0063 0.0357
Trypanosoma brucei Replication factor A protein 1 0.0332 0.176 1
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0039 0.0219
Leishmania major leucyl-tRNA synthetase, putative 0.0056 0.0212 0.1205
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0234
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0048 0.026
Echinococcus multilocularis glycyl tRNA synthetase 0.0274 0.1435 0.1435
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0048 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0412 0.1088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0075
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0034 0.0089 0.0634
Plasmodium vivax methionine--tRNA ligase, putative 0.0056 0.0212 0.1195
Plasmodium vivax asparagine--tRNA ligase, putative 0.0034 0.0089 0.0493
Trichomonas vaginalis protein phosphatase, caeel, putative 0.003 0.0063 0.0166
Giardia lamblia Aspartyl-tRNA synthetase 0.0034 0.0089 0.1903
Echinococcus multilocularis snurportin 1 0.0301 0.1586 0.1586
Brugia malayi Integrin beta pat-3 precursor 0.0378 0.2021 0.5341
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Schistosoma mansoni hypothetical protein 0.0142 0.0694 0.1025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.1461 0.1461
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0122 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.1461 0.2159
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0274 0.1435 0.3791
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.003 0.0063 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Giardia lamblia Asparaginyl-tRNA synthetase 0.0034 0.0089 0.1903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0222 0.0222
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.1335 1
Onchocerca volvulus 0.004 0.0122 0.0356
Giardia lamblia Methionyl-tRNA synthetase 0.0056 0.0212 0.4558
Loa Loa (eye worm) hypothetical protein 0.014 0.0681 0.1801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.1586 0.419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1461 0.2159
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0412 0.0609
Loa Loa (eye worm) hypothetical protein 0.004 0.012 0.0316
Onchocerca volvulus 0.004 0.0122 0.0356
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0019 0.0002 0.0011
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0013 0.002
Giardia lamblia Lysyl-tRNA synthetase 0.0034 0.0089 0.1903
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0023
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0019 0.0002 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0122 0.0693
Plasmodium falciparum replication protein A1, large subunit 0.0332 0.176 1
Schistosoma mansoni glycyl-tRNA synthetase 0.0274 0.1435 0.212
Schistosoma mansoni hypothetical protein 0.0142 0.0694 0.1025
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0035
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0056 0.0212 0.0561
Brugia malayi beta-lactamase family protein 0.004 0.0122 0.0322
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0145
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0034 0.0089 0.0089
Toxoplasma gondii ABC1 family protein 0.004 0.0122 0.0693
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0004 0.0004
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.003 0.0063 0.0166
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0095 0.0095
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0000014378 0.0000021245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Schistosoma mansoni protein phosphatase type 1 0.003 0.0063 0.0093
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0025 0.0066
Plasmodium vivax lysine--tRNA ligase, putative 0.0034 0.0089 0.0493
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0075
Brugia malayi Integrin alpha pat-2 precursor 0.0185 0.0934 0.2468
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0472
Schistosoma mansoni lysyl-tRNA synthetase 0.0034 0.0089 0.0131
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0412 0.1088
Schistosoma mansoni cpg binding protein 0.012 0.0572 0.0846
Schistosoma mansoni methionine-tRNA synthetase 0.0056 0.0212 0.0313
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0412 0.1088
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0034 0.0089 0.0089
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0056 0.0082
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0142 0.0694 0.1025
Schistosoma mansoni cpg binding protein 0.012 0.0572 0.0846
Brugia malayi Integrin alpha cytoplasmic region family protein 0.014 0.0681 0.1801
Entamoeba histolytica Ran family GTPase 0.0021 0.0013 0.0071
Echinococcus granulosus dnaJ subfamily B 0.1223 0.6768 1
Trypanosoma brucei polo-like protein kinase 0.0092 0.0412 0.234
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0004 0.0023
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0013 0.0013
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0332 0.176 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0004 0.0022
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0034 0.0089 0.0089
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0034 0.0089 0.0131
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.003 0.0063 0.0347
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0000014378 0.0000021245
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0122 0.0885
Brugia malayi Kelch motif family protein 0.0057 0.022 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Plasmodium vivax hypothetical protein, conserved 0.004 0.0122 0.0683
Toxoplasma gondii serine/threonine phosophatase PP1 0.003 0.0063 0.0357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.1461 0.2159
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.1043 0.1043
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0056 0.0056
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0142 0.0694 0.1833
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0274 0.1435 0.3791
Leishmania major elongation factor 1-gamma, putative 0.0019 0.0002 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0122 0.0885
Trypanosoma brucei elongation factor 1 gamma, putative 0.0019 0.0002 0.0011
Trypanosoma cruzi Replication factor A protein 1 0.0332 0.176 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0322
Plasmodium falciparum lysine--tRNA ligase 0.0034 0.0089 0.0493
Giardia lamblia Hypothetical protein 0.0101 0.0465 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0122 0.5666
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0182 0.0534
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.011
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0000014378 0.0000081679
Mycobacterium ulcerans lipase LipD 0.004 0.0122 0.5666
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0056 0.0212 1
Echinococcus multilocularis cpg binding protein 0.012 0.0572 0.0572
Plasmodium vivax asparagine--tRNA ligase, putative 0.0034 0.0089 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Loa Loa (eye worm) integrin beta-2 0.0378 0.2021 0.5341
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0034 0.0089 0.412
Leishmania major hypothetical protein, conserved 0.0027 0.0048 0.0271
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0322
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0692 0.3784 1
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.003 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0067 0.0274 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0067 0.0274 0.0805
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0353 0.1877 0.2773
Schistosoma mansoni protein phosphatase type 1 0.003 0.0063 0.0093
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.0066
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0122 0.5666
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.003 0.0063 0.0093
Entamoeba histolytica replication factor A protein 1, putative 0.0298 0.1569 0.8357
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0122 0.018
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0056 0.0212 1
Toxoplasma gondii tRNA ligases class I (M) protein 0.0056 0.0212 0.1205
Loa Loa (eye worm) hypothetical protein 0.0051 0.0182 0.0481
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.003 0.0063 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0122 0.0322
Plasmodium falciparum importin beta, putative 0.0028 0.0055 0.0302
Brugia malayi beta-lactamase family protein 0.004 0.0122 0.0322
Schistosoma mansoni hypothetical protein 0.0164 0.0821 0.1213
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0039 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.011
Schistosoma mansoni cpg binding protein 0.0114 0.0536 0.0792
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0089 0.0503
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0412 0.234
Trichomonas vaginalis ran, putative 0.0021 0.0013 0.0035
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0013 0.0075
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0055 0.0313
Schistosoma mansoni protein phosphatase-1 0.003 0.0063 0.0093
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0042 0.011
Loa Loa (eye worm) hypothetical protein 0.0057 0.022 0.058
Plasmodium falciparum asparagine--tRNA ligase 0.0034 0.0089 0.0493
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0353 0.1877 0.1877
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0122 0.0693
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0000014378 0.0000081679
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0152 0.0401
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Mycobacterium tuberculosis Conserved protein 0.004 0.0122 0.0885
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0042 0.011
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0322
Schistosoma mansoni integrin alpha-ps 0.0083 0.0362 0.0535
Giardia lamblia Elongation factor 1-gamma 0.0019 0.0002 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0412 0.1088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0039 0.0102
Plasmodium falciparum methionine--tRNA ligase, putative 0.0056 0.0212 0.1195
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0412 0.1088
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0043 0.0139 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0412 0.234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0122 0.0885
Brugia malayi methionyl-tRNA synthetase 0.0056 0.0212 0.0561
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0212 0.1195
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0034 0.0089 0.0131
Treponema pallidum asparaginyl-tRNA synthetase 0.0034 0.0089 0.0451
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0234
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0412 0.1215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1461 0.2159
Entamoeba histolytica hypothetical protein 0.0034 0.0089 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0005
Toxoplasma gondii methionyl-tRNA synthetase 0.0056 0.0212 0.1205
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0000014378 0.0000081679
Giardia lamblia Kinase, PLK 0.0092 0.0412 0.8849
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0122 0.0322
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0274 0.1435 0.3791
Chlamydia trachomatis leucine--tRNA ligase 0.0056 0.0212 0.0691
Echinococcus multilocularis dnaJ subfamily B 0.1223 0.6768 0.6768
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0796 0.4366 0.4366
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0048 0.027
Brugia malayi hypothetical protein 0.0019 0.0002 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0122 0.0322
Giardia lamblia Leucyl-tRNA synthetase 0.0056 0.0212 0.4558
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0056 0.0082
Brugia malayi hypothetical protein 0.0027 0.0048 0.0126
Entamoeba histolytica hypothetical protein 0.0025 0.0039 0.0205
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0056 0.0212 0.1205
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0279 0.1461 0.3862
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0000014378 0.0000081679
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0057 0.022 0.058
Schistosoma mansoni hypothetical protein 0.0164 0.0821 0.1213
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Trypanosoma brucei elongation factor 1 gamma, putative 0.0019 0.0002 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.011
Echinococcus granulosus integrin alpha 3 0.0142 0.0692 0.1022
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0019 0.0002 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0412 0.1088
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0019 0.0002 0.0005
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Echinococcus granulosus snurportin 1 0.0301 0.1586 0.2343
Entamoeba histolytica hypothetical protein 0.0034 0.0089 0.0472
Echinococcus granulosus geminin 0.0164 0.0821 0.1213
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0034 0.0089 0.0131
Schistosoma mansoni apoptosis regulator bax 0.0142 0.0694 0.1025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0042 0.011
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0075
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0092 0.0243
Echinococcus granulosus lysyl tRNA synthetase 0.0034 0.0089 0.0131
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0056 0.0212 1
Leishmania major methionyl-tRNA synthetase, putative 0.0056 0.0212 0.1205
Entamoeba histolytica replication factor A, putative 0.0067 0.0274 0.1458
Echinococcus granulosus integrin alpha ps 0.0083 0.0362 0.0535
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0056 0.0212 0.1205
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0692 0.3784 1
Schistosoma mansoni integrin alpha-ps 0.0043 0.0139 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0412 0.1088
Echinococcus multilocularis glutathione S transferase 0.0019 0.0002 0.0002
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0222 0.0328
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0034 0.0089 0.0472
Leishmania major lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0034 0.0089 0.0503
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0000014378 0.0000081679
Echinococcus multilocularis leucyl tRNA synthetase 0.0056 0.0212 0.0212
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0004 0.0023
Leishmania major aspartyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Echinococcus granulosus integrin beta 2 0.028 0.1471 0.2173
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0 0.0001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0000014378 0.0000081679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0056 0.0082
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0285
Loa Loa (eye worm) hypothetical protein 0.0058 0.0222 0.0586
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0025 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1461 0.2159
Schistosoma mansoni integrin alpha 0.0185 0.0934 0.138
Treponema pallidum methionyl-tRNA synthetase 0.0353 0.1877 1
Entamoeba histolytica hypothetical protein 0.0023 0.0025 0.0134
Echinococcus multilocularis integrin alpha ps 0.004 0.012 0.012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0216 0.1107 0.6291
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0122 0.0322
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0019 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Brugia malayi CXXC zinc finger family protein 0.0114 0.0536 0.1416
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0222 0.0328
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0039 0.0219
Echinococcus granulosus cpg binding protein 0.012 0.0572 0.0846
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0412 0.1088
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0122 0.018
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0182 0.0269
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0142 0.0694 0.0694
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0034 0.0089 0.0234
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0049
Mycobacterium ulcerans beta-lactamase 0.004 0.0122 0.5666
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0000014378 0.0000081679
Brugia malayi lysyl-tRNA synthetase 0.0034 0.0089 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0000014378 0.0000076603
Schistosoma mansoni lysyl-tRNA synthetase 0.0034 0.0089 0.0131
Leishmania major replication Factor A 28 kDa subunit, putative 0.0034 0.0089 0.0503
Loa Loa (eye worm) hypothetical protein 0.003 0.0063 0.0166
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0025 0.0066
Toxoplasma gondii hypothetical protein 0.0073 0.0305 0.1733
Echinococcus granulosus methionine tRNA synthetase 0.0056 0.0212 0.0313
Leishmania major lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0503
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0000014378 0.0000037992
Toxoplasma gondii exonuclease III APE 0.0019 0.0004 0.0023
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0019 0.0002 0.0011
Plasmodium falciparum methionine--tRNA ligase 0.0056 0.0212 0.1195
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0042 0.011
Brugia malayi hypothetical protein 0.0057 0.022 0.058
Loa Loa (eye worm) hypothetical protein 0.0102 0.0469 0.1239
Loa Loa (eye worm) histone methyltransferase 0.0035 0.0095 0.025
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0034 0.0089 0.0234
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0089 0.0131

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 48 nM Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assay ChEMBL. 10633037
IC50 (functional) = 48 nM Inhbitory activity against beta3-transfected 293 cells using alpha-V beta-3 antagonism assay ChEMBL. 10633037
IC50 (functional) = 220 nM Inhibition of aggregation of human gel-purified platelets (GPIIbIIIa GPP) ChEMBL. 10633037
IC50 (functional) = 220 nM Inhibition of aggregation of human gel-purified platelets (GPIIbIIIa GPP) ChEMBL. 10633037

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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