Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0058 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0058 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0862 | 0.0862 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0058 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0862 | 0.0862 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0058 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0058 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0862 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0058 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0862 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0058 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.5203 | 0.5203 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0058 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0862 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0862 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0862 | 0.0862 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.5203 | 0.5203 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0862 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.9686 | 0.9686 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0058 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0058 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.5203 | 0.5203 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0862 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0058 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.9686 | 0.9686 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.9686 | 0.9686 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0862 | 0.0862 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.9686 | 0.9686 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0058 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0862 | 0.0862 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0862 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Delta G (binding) | = 6.5 kCal mol-1 | Binding energy of the compound to Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7120278 |
-Delta G (binding) | = 6.5 kCal mol-1 | Binding energy of the compound to Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7120278 |
Delta G (binding) | = -6.5 kCal | Binding energy against Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7392027 |
Delta G (binding) | = -6.5 kCal | Binding energy against Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7392027 |
log(1/I50) (binding) | = 4.05 | Inhibition of thymidylate synthetase in Lactobacillus casei | ChEMBL. | 110930 |
log(1/I50) (binding) | = 4.05 | Inhibition of thymidylate synthetase in mouse L1210S cells | ChEMBL. | 110930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.