TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 523.612 | Formula: C27H39F2N3O5
H donors: 3 H acceptors: 5 LogP: 4.99 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: O=CN(C[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)c1cc(F)c(cc1N1CCC(CC1)O)F)CC1CCCC1)O
InChi: 1S/C27H39F2N3O5/c1-27(2,3)25(30-26(36)18(15-32(37)16-33)12-17-6-4-5-7-17)24(35)20-13-21(28)22(29)14-23(20)31-10-8-19(34)9-11-31/h13-14,16-19,25,34,37H,4-12,15H2,1-3H3,(H,30,36)/t18-,25-/m1/s1
InChiKey: ACTMAVUNQPFPJO-IQGLISFBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	peptide deformylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium yoelii	polypeptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium ulcerans	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium vivax	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	Get druggable targets OG5_128237	All targets in OG5_128237
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	Get druggable targets OG5_128237	All targets in OG5_128237
Chlamydia trachomatis	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium falciparum	peptide deformylase	Get druggable targets OG5_128237	All targets in OG5_128237
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128237	All targets in OG5_128237
Neospora caninum	Peptide deformylase, related	Get druggable targets OG5_128237	All targets in OG5_128237
Treponema pallidum	polypeptide deformylase (def)	Get druggable targets OG5_128237	All targets in OG5_128237
Plasmodium knowlesi	peptide deformylase, putative	Get druggable targets OG5_128237	All targets in OG5_128237

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	patched 1	0.0078	0.0127	0.0127
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0113	0.0206	0.0245
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0113	0.0206	0.0269
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0017	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0017	0.0025
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.2097	0.4756	0.4756
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0011	0.0011
Plasmodium falciparum	peptide deformylase	0.0279	0.0587	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0244	0.0507	0.057
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0113	0.0206	0.0245
Leishmania major	polypeptide deformylase-like protein, putative	0.0106	0.0192	0.0243
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0011	0.0016
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0011	0.0011
Brugia malayi	hypothetical protein	0.0038	0.0036	0.0052
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0206	0.0232
Echinococcus granulosus	muscleblind protein	0.0244	0.0507	0.0507
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.4385	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0011	0.0011
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0101	0.0179	0.0179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0011	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0113	0.0206	0.0245
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0154	0.03	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Trypanosoma cruzi	target of rapamycin kinase 3	0.0113	0.0206	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0113	0.0206	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.172	0.389	0.5589
Schistosoma mansoni	opsin-like receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	hypothetical protein	0.0028	0.0011	0.0011
Echinococcus multilocularis	muscleblind protein 1	0.0244	0.0507	0.0507
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.0041	0.0042	0.0008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.2576	0.5852	0.84
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0017	0.0017
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0017	0.0017
Echinococcus multilocularis		0.0113	0.0206	0.0206
Leishmania major	hypothetical protein, conserved	0.0113	0.0206	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0495	0.1083	0.1083
Plasmodium vivax	ataxin-2 like protein, putative	0.0039	0.0038	0.0004
Loa Loa (eye worm)	calpain family protein 1	0.0061	0.0089	0.01
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0154	0.03	0.0419
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0017	0.0501
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0011	0.0011
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0279	0.0587	0.0873
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0495	0.1083	0.1656
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0866	0.1933	0.274
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0495	0.1083	0.1512
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0182	0.0366	0.0476
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0036	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0206	0.0232
Loa Loa (eye worm)	phosphatidylinositol 3	0.3902	0.8892	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0017	0.0025
Onchocerca volvulus		0.0101	0.0179	0.5238
Echinococcus granulosus	GPCR family 2	0.0134	0.0256	0.0256
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0017	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0017	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0424	0.0921	0.1035
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0036	0.004
Echinococcus granulosus	serotonin receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0038	0.0043
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0011	0.0013
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0206	0.0232
Plasmodium vivax	hypothetical protein	0.0113	0.0206	0.0269
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.109	0.2447	0.3483
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0113	0.0206	0.0206
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.3059	0.696	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0495	0.1083	0.1083
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0113	0.0206	0.0206
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0011	0.0013
Leishmania major	dihydroorotate dehydrogenase	0.2792	0.6349	1
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0011	0.0011
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.2947	0.6702	0.9627
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0017	0.0025
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0495	0.1083	0.1512
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0011	0.0013
Schistosoma mansoni	hypothetical protein	0.0134	0.0256	0.0256
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0017	0.0017
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0134	0.0256	0.0256
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0017	0.0025
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.2792	0.6349	1
Brugia malayi	GnHR receptor homolog	0.0028	0.0011	0.0016
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0017	0.0017
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0134	0.0256	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0025	0.0006	0.0009
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0011	0.0011
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0424	0.0921	0.1323
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0011	0.0016
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0017	0.0017
Loa Loa (eye worm)	phosphatidylinositol 3	0.0866	0.1933	0.2174
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0106	0.0192	0.0225
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0113	0.0206	0.0245
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0495	0.1083	0.1556
Schistosoma mansoni	hypothetical protein	0.0028	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.0041	0.0042	0.0008
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	serine protein kinase ATM	0.0113	0.0206	0.0206
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0495	0.1083	0.1659
Echinococcus multilocularis	tar DNA binding protein	0.0136	0.0261	0.0261
Echinococcus multilocularis	nibrin	0.0038	0.0036	0.0036
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0113	0.0206	0.0269
Schistosoma mansoni	amine GPCR	0.0028	0.0011	0.0011
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0017	0.0501
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0424	0.0921	0.1035
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0113	0.0206	0.0245
Schistosoma mansoni	hypothetical protein	0.003	0.0017	0.0017
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0011	0.0011
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0495	0.1083	0.1512
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0113	0.0206	0.0245
Schistosoma mansoni	amine GPCR	0.0028	0.0011	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Brugia malayi	DKFZp564C0469 protein	0.0038	0.0036	0.0052
Onchocerca volvulus		0.0038	0.0036	0.105
Echinococcus granulosus	microtubule associated protein 2	0.0658	0.1455	0.1455
Brugia malayi	Zinc finger, C2H2 type family protein	0.109	0.2447	0.3516
Loa Loa (eye worm)	calpain family protein 1	0.0043	0.0047	0.0053
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0113	0.0206	0.0269
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0424	0.0921	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0495	0.1083	0.1659
Brugia malayi	Serotonin receptor	0.0028	0.0011	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Onchocerca volvulus		0.0028	0.0011	0.0334
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Trypanosoma brucei	Peptide deformylase 2	0.0106	0.0192	0.0247
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0038	0.0036	0.0052
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0011	0.0011
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0011	0.0011
Echinococcus multilocularis	Niemann Pick C1 protein	0.0182	0.0366	0.0366
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0065	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0179	0.0202
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0017	0.0017
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0206	0.0206
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.109	0.2447	0.2447
Brugia malayi	Muscleblind-like protein	0.0244	0.0507	0.0729
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Onchocerca volvulus		0.0028	0.0011	0.0334
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0011	0.0011
Brugia malayi	G-protein coupled receptor	0.0028	0.0011	0.0016
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.2792	0.6349	0.9122
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	protein patched	0.0078	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0495	0.1083	0.1659
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0011	0.0011
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0113	0.0206	0.0206
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.0206	0.0245
Plasmodium falciparum	ataxin-2 like protein, putative	0.0039	0.0038	0.0004
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	TAR-binding protein	0.0136	0.0261	0.0293
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0011	0.0011
Onchocerca volvulus		0.009	0.0154	0.4485
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0011	0.0011
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0495	0.1083	0.1659
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0113	0.0206	0.0269
Echinococcus multilocularis	GPCR, family 2	0.0134	0.0256	0.0256
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.0261	0.0261
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.109	0.2447	0.3483
Schistosoma mansoni	adenoreceptor	0.0028	0.0011	0.0011
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0113	0.0206	0.0206
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.3059	0.696	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0017	0.0025
Schistosoma mansoni	hypothetical protein	0.0028	0.0011	0.0011
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0011	0.0011
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0113	0.0206	0.0245
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Brugia malayi	hypothetical protein	0.0472	0.103	0.148
Toxoplasma gondii	ATPase, AAA family protein	0.0038	0.0036	0.00000026108
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0113	0.0206	0.0245
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0154	0.03	0.0419
Echinococcus granulosus	hypothetical protein	0.0028	0.0011	0.0011
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0011	0.0011
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.2792	0.6349	0.9117
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0379	0.0817	0.0817
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0017	0.0025
Echinococcus multilocularis	thyroid hormone receptor alpha	0.003	0.0017	0.0017
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0061	0.0089	0.0089
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0017	0.0017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0017	0.0017
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0113	0.0206	0.0269
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0206	0.0232
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1236	0.2782	0.3966
Onchocerca volvulus		0.0028	0.0011	0.0334
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.1339	0.3018	0.3394
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0075	0.0121	0.0121
Echinococcus granulosus	calpain A	0.0065	0.0096	0.0096
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0113	0.0206	0.0266
Brugia malayi	hypothetical protein	0.0041	0.0042	0.006
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0011	0.0016
Schistosoma mansoni	hypothetical protein	0.0096	0.0169	0.0169
Echinococcus multilocularis	muscleblind protein	0.0244	0.0507	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0011	0.0011
Echinococcus granulosus	lysine specific demethylase 5A	0.0067	0.0101	0.0101
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0206	0.0296
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0011	0.0013
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0495	0.1083	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	Zinc finger, PHD finger	0.0495	0.1083	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0127	0.0143
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0011	0.0011
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0979	0.2191	0.3112
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0011	0.0011
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.0011	0.0334
Onchocerca volvulus		0.0113	0.0206	0.6014
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0011	0.0016
Onchocerca volvulus		0.003	0.0017	0.0501
Echinococcus multilocularis	calpain family protein 1, d	0.0043	0.0047	0.0047
Entamoeba histolytica	hypothetical protein	0.0113	0.0206	0.0245
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.0261	0.0261
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0244	0.0507	0.057
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0113	0.0206	0.0206
Onchocerca volvulus		0.0028	0.0011	0.0334
Echinococcus granulosus	tar DNA binding protein	0.0136	0.0261	0.0261
Schistosoma mansoni	amine GPCR	0.0028	0.0011	0.0011
Brugia malayi	nuclear receptor NHR-88	0.003	0.0017	0.0025
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Schistosoma mansoni	hypothetical protein	0.0075	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0206	0.0232
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.2792	0.6349	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0011	0.0011
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.2792	0.6349	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0495	0.1083	0.1512
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0011	0.0011
Entamoeba histolytica	protein kinase rad3, putative	0.0113	0.0206	0.0245
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0134	0.0256	0.0256
Schistosoma mansoni	topbp1	0.0038	0.0036	0.0036
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0279	0.0587	0.062
Schistosoma mansoni	amine GPCR	0.0028	0.0011	0.0011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0017	0.0019
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0134	0.0256	0.0288
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.2792	0.6349	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0011	0.0011
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.109	0.2447	0.3483
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0011	0.0011
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0038	0.0036	0.00000023803
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0011	0.0011
Brugia malayi	Pax transcription activation domain interacting protein	0.0038	0.0036	0.0052
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0011	0.0011
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0113	0.0206	0.0245
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0495	0.1083	0.1512
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0011	0.0016
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0113	0.0206	0.0269
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Schistosoma mansoni	hypothetical protein	0.0075	0.0121	0.0121
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0011	0.0011
Brugia malayi	Trypsin family protein	0.0101	0.0179	0.0258
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0067	0.0101	0.0101
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0495	0.1083	0.1083
Schistosoma mansoni	hypothetical protein	0.0028	0.0011	0.0011
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0017	0.0025
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0113	0.0206	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus granulosus	Niemann Pick C1 protein	0.026	0.0545	0.0545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	serotonin receptor	0.0028	0.0011	0.0011
Mycobacterium ulcerans	peptide deformylase	0.0279	0.0587	0.0873
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0011	0.0011
Brugia malayi	MH2 domain containing protein	0.0191	0.0386	0.0554
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0206	0.0206
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0979	0.2191	0.3112
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0011	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0017	0.0025
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0113	0.0206	0.0269
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0495	0.1083	0.1656
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Onchocerca volvulus		0.0028	0.0011	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0366	0.0411
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.3059	0.696	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0036	0.004
Brugia malayi	larval opioid receptor	0.0028	0.0011	0.0016
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.0042	0.0042
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0065	0.0096	0.0096
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0596	0.1314	0.3104
Onchocerca volvulus		0.0028	0.0011	0.0334
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0113	0.0206	0.0269
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0113	0.0206	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0113	0.0206	0.0269
Brugia malayi	steroid hormone receptor	0.003	0.0017	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0206	0.0232
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0011	0.0011
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0113	0.0206	0.0266
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0011	0.0011
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0011	0.0011
Echinococcus granulosus	replication factor c subunit 1	0.0038	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Schistosoma mansoni	chromosome transmission fidelity factor	0.0038	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Onchocerca volvulus		0.0028	0.0011	0.0334
Trypanosoma brucei	PAB1-binding protein , putative	0.0039	0.0038	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.0101	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	serotonin receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0038	0.0036	0.00000023803
Leishmania major	phosphatidylinositol kinase, putative	0.0113	0.0206	0.0266
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0495	0.1083	0.1083
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0113	0.0206	0.0206
Onchocerca volvulus		0.0028	0.0011	0.0334
Loa Loa (eye worm)	transcription factor SMAD2	0.0191	0.0386	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0011	0.0011
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.2792	0.6349	1
Brugia malayi	ecdysteroid receptor	0.003	0.0017	0.0025
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0472	0.103	0.1158
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.4385	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0017	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0017	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0036	0.004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0011	0.0011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0011	0.0013
Echinococcus multilocularis	calpain A	0.0065	0.0096	0.0096
Schistosoma mansoni	hypothetical protein	0.003	0.0017	0.0017
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0495	0.1083	0.1218
Schistosoma mansoni	opsin-like receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	hypothetical protein	0.0075	0.0121	0.0121
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0065	0.0096	0.0096
Schistosoma mansoni	dihydroorotate dehydrogenase	0.2792	0.6349	0.6349
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0047	0.0053
Echinococcus multilocularis	microtubule associated protein 2	0.0658	0.1455	0.1455
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.109	0.2447	0.2447
Toxoplasma gondii	FATC domain-containing protein	0.0113	0.0206	0.0269
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Onchocerca volvulus		0.0113	0.0206	0.6014
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.2792	0.6349	0.9117
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0011	0.0011
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0017	0.0025
Loa Loa (eye worm)	apoptosis regulator protein	0.003	0.0017	0.0019
Brugia malayi	hypothetical protein	0.0039	0.0038	0.0055
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0036	0.004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0011	0.0011
Onchocerca volvulus		0.0172	0.0342	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0017	0.0017
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0011	0.0013
Brugia malayi	G protein-coupled receptor	0.0028	0.0011	0.0016
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.2792	0.6349	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0089	0.01
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0011	0.0011
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0017	0.0017
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0017	0.0017
Echinococcus multilocularis	expressed conserved protein	0.0171	0.034	0.034
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0279	0.0587	0.0873
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0113	0.0206	0.0206
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0017	0.0017
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0113	0.0206	0.0269
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0017	0.0025
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0011	0.0011
Brugia malayi	neuropeptide F receptor	0.0028	0.0011	0.0016
Schistosoma mansoni	microtubule-associated protein tau	0.0658	0.1455	0.1455
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0113	0.0206	0.0245
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0011	0.0016
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0011	0.0011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0017	0.0019
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0113	0.0206	0.0266
Onchocerca volvulus		0.0028	0.0011	0.0334
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0206	0.0232
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0017	0.0025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Brugia malayi	nuclear hormone receptor	0.003	0.0017	0.0025
Brugia malayi	Dopamine receptor	0.0028	0.0011	0.0016
Onchocerca volvulus		0.0028	0.0011	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Loa Loa (eye worm)	MH2 domain-containing protein	0.0191	0.0386	0.0434
Brugia malayi	hypothetical protein	0.0172	0.0342	0.0492
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0206	0.0296
Brugia malayi	putative neuropeptide receptor	0.0028	0.0011	0.0016
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.2318	0.5261	0.7546
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0078	0.0127	0.0143
Plasmodium vivax	hypothetical protein, conserved	0.0113	0.0206	0.0269
Echinococcus granulosus	Protein patched homolog 1	0.0078	0.0127	0.0127
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0113	0.0206	0.0245
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0495	0.1083	0.1512
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0096	0.0169	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Chlamydia trachomatis	peptide deformylase	0.0279	0.0587	1
Loa Loa (eye worm)	hypothetical protein	0.172	0.389	0.4375
Brugia malayi	Niemann-Pick C1 protein precursor	0.0182	0.0366	0.0525
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.172	0.389	0.389
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0342	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0089	0.01
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0495	0.1083	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Entamoeba histolytica	hypothetical protein	0.0113	0.0206	0.0245
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0017	0.0017
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0017	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Entamoeba histolytica	hypothetical protein	0.0113	0.0206	0.0245
Schistosoma mansoni	hypothetical protein	0.0134	0.0256	0.0256
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0113	0.0206	0.0206
Echinococcus granulosus	serine protein kinase ATM	0.0113	0.0206	0.0206
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0011	0.0016
Trichomonas vaginalis	hypothetical protein	0.0154	0.03	0.0382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trypanosoma cruzi	PAB1-binding protein , putative	0.0039	0.0038	0.0003
Leishmania major	hypothetical protein, unknown function	0.0113	0.0206	0.0266
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0113	0.0206	0.0206
Onchocerca volvulus		0.0028	0.0011	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.2576	0.5852	0.84
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0113	0.0206	0.0206
Echinococcus multilocularis	replication factor c subunit 1	0.0038	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Brugia malayi	sulfakinin receptor protein	0.0028	0.0011	0.0016
Schistosoma mansoni	topbp1	0.0038	0.0036	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0011	0.0011
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0113	0.0206	0.0413
Brugia malayi	TAR-binding protein	0.0136	0.0261	0.0375
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0113	0.0206	0.0269
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0017	0.0017
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0011	0.0011
Schistosoma mansoni	apoptosis regulator bax	0.003	0.0017	0.0017
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0106	0.0192	0.0225
Brugia malayi	RE15519p	0.0028	0.0011	0.0016
Treponema pallidum	polypeptide deformylase (def)	0.0279	0.0587	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0472	0.103	0.103
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0113	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0017	0.0025
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0017	0.0017
Giardia lamblia	GTOR	0.0113	0.0206	0.0413
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0134	0.0256	0.0256
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0011	0.0011
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.0041	0.0042	0.0008
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0206	0.0232
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0017	0.0017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0011	0.0013
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.003	0.0017	0.0025
Brugia malayi	latrophilin 2 splice variant baaae	0.029	0.0613	0.088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0017	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Schistosoma mansoni	survival motor neuron protein	0.0096	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0036	0.004
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.172	0.389	0.389
Brugia malayi	calpain family protein 1	0.0061	0.0089	0.0127
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0113	0.0206	0.0269
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0154	0.03	0.4795
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.109	0.2447	0.3483
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0047	0.0053
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0011	0.0013
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.3059	0.696	1
Brugia malayi	AKH receptor	0.0028	0.0011	0.0016
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0011	0.0011
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0011	0.0011
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0011	0.0011
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.109	0.2447	0.3483
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0017	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Brugia malayi	G-protein coupled receptor	0.0028	0.0011	0.0016
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0113	0.0206	0.0269
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.2318	0.5261	0.7546
Trypanosoma cruzi	PAB1-binding protein , putative	0.0039	0.0038	0.0003
Brugia malayi	Serotonin receptor	0.0028	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Onchocerca volvulus		0.0028	0.0011	0.0334
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0127	0.0132
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0011	0.0011
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0011	0.0016
Schistosoma mansoni	jumonji domain containing protein	0.0067	0.0101	0.0101
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.109	0.2447	0.2447
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0011	0.0011
Echinococcus multilocularis	lysine specific demethylase 5A	0.0067	0.0101	0.0101
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0113	0.0206	0.0245
Schistosoma mansoni	hypothetical protein	0.0134	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Onchocerca volvulus		0.0028	0.0011	0.0334
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.3059	0.696	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Brugia malayi	hypothetical protein	0.0038	0.0036	0.0052
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0979	0.2191	0.3112
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0017	0.0025
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0038	0.0036	0.00000023803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0167	0.0188
Toxoplasma gondii	LsmAD domain-containing protein	0.0039	0.0038	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0017	0.0017
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.2792	0.6349	0.9122
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0017	0.0017
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0979	0.2191	0.3112
Onchocerca volvulus		0.0028	0.0011	0.0334
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.0011	0.0334
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0134	0.0256	0.0256
Plasmodium falciparum	ataxin-2 like protein, putative	0.0039	0.0038	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0011	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0011	0.0011
Brugia malayi	neuropeptide F receptor	0.0028	0.0011	0.0016
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0113	0.0206	0.0245
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0011	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Onchocerca volvulus		0.0043	0.0047	0.1365
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.0261	0.0261
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0206	0.0296
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0011	0.0011
Onchocerca volvulus		0.0028	0.0011	0.0334
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0011	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0134	0.0256	0.0256
Echinococcus granulosus	somatostatin receptor	0.0028	0.0011	0.0011
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0106	0.0192	0.0225
Echinococcus granulosus	sex peptide receptor	0.0028	0.0011	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0185	0.0372	0.0372
Echinococcus multilocularis	Niemann Pick C1 protein	0.026	0.0545	0.0545
Schistosoma mansoni	DNA ligase IV	0.0038	0.0036	0.0036
Schistosoma mansoni	myosin xvIII	0.0028	0.0011	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.109	0.2447	0.3483
Echinococcus multilocularis	protein dispatched 1	0.0089	0.0152	0.0152
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0011	0.0011
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0206	0.0296
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0011	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Schistosoma mansoni	hypothetical protein	0.029	0.0613	0.0613
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0113	0.0206	0.0245
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0011	0.0011
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0017	0.0019
Echinococcus granulosus	expressed conserved protein	0.0171	0.034	0.034
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0154	0.03	0.0419
Schistosoma mansoni	amine GPCR	0.0028	0.0011	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.0042	0.0042
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0067	0.0101	0.0101
Trypanosoma brucei	Polypeptide deformylase 1	0.0106	0.0192	0.0247
Onchocerca volvulus		0.0028	0.0011	0.0334
Echinococcus granulosus	Niemann Pick C1 protein	0.0182	0.0366	0.0366
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0011	0.0011
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0979	0.2191	0.3414
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0206	0.0296
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Entamoeba histolytica	hypothetical protein	0.0041	0.0042	0.0008
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0113	0.0206	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.109	0.2447	0.3483
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0256	0.0288
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0113	0.0206	0.0206
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.3059	0.696	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0011	0.0011
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0011	0.0011
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0206	0.0296
Brugia malayi	jmjC domain containing protein	0.0067	0.0101	0.0146
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0979	0.2191	0.3112
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0011	0.0013
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0011	0.0011
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0113	0.0206	0.0296
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0011	0.0011
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0113	0.0206	0.0266
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0011	0.0011
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0011	0.0011
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0979	0.2191	0.3148
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0011	0.0011
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0011	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0011	0.0011
Brugia malayi	jmjC domain containing protein	0.0067	0.0101	0.0146
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0011	0.0011
Brugia malayi	RNA binding protein	0.0136	0.0261	0.0375
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0067	0.0101	0.0101
Toxoplasma gondii	hypothetical protein	0.0279	0.0587	0.0873
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0017	0.0019
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0113	0.0206	0.0206
Plasmodium falciparum	dihydroorotate dehydrogenase	0.2792	0.6349	1
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.1835	0.4153	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0113	0.0206	0.0206
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0011	0.0011
Mycobacterium leprae	conserved hypothetical protein	0.0113	0.0206	0.0269
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0113	0.0206	0.0206
Brugia malayi	Latrophilin receptor protein 2	0.0134	0.0256	0.0367
Schistosoma mansoni	hypothetical protein	0.003	0.0017	0.0017
Brugia malayi	CHE-14 protein	0.0078	0.0127	0.0183
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0067	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Loa Loa (eye worm)	hypothetical protein	0.029	0.0613	0.0689
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0106	0.0192	0.0225
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0154	0.03	0.0419
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Schistosoma mansoni	hypothetical protein	0.0041	0.0042	0.0042
Onchocerca volvulus		0.0028	0.0011	0.0334
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0017	0.0017
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0979	0.2191	0.2191
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0011	0.0011
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0011	0.0011
Schistosoma mansoni	coup transcription factor	0.003	0.0017	0.0017
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.109	0.2447	0.3483
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0113	0.0206	0.0206
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0113	0.0206	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0065	0.0096	0.0096
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.109	0.2447	0.2447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0495	0.1083	0.1659
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0379	0.0817	0.0817
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Echinococcus granulosus	nibrin	0.0038	0.0036	0.0036
Schistosoma mansoni	hypothetical protein	0.0113	0.0206	0.0206
Loa Loa (eye worm)	phosphatidylinositol 3	0.0113	0.0206	0.0232
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0017	0.0017
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0113	0.0206	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0011	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0179	0.0202
Brugia malayi	RNA recognition motif domain containing protein	0.0136	0.0261	0.0375
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0136	0.0261	0.0293
Echinococcus granulosus	sterol regulatory element binding protein	0.0078	0.0127	0.0127
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.3059	0.696	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0011	0.0011
Schistosoma mansoni	opsin-like receptor	0.0028	0.0011	0.0011
Echinococcus granulosus	survival motor neuron protein 1	0.0472	0.103	0.103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Onchocerca volvulus		0.0096	0.0169	0.4924
Giardia lamblia	Hypothetical protein	0.0113	0.0206	0.0413
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0113	0.0206	0.0269
Loa Loa (eye worm)	RNA binding protein	0.0136	0.0261	0.0293
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.003	0.0017	0.0017
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.2792	0.6349	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.0042	0.0042
Echinococcus multilocularis	sterol regulatory element binding protein	0.0078	0.0127	0.0127
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0113	0.0206	0.0269
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0101	0.0179	0.0179
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0011	0.0011
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.1326	0.2988	0.4292
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.003	0.0017	0.0017
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0011	0.0011
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0011	0.0011
Brugia malayi	topoisomerase	0.0038	0.0036	0.0052
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0154	0.03	0.0153
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.2792	0.6349	0.9117
Plasmodium vivax	peptide deformylase, putative	0.0279	0.0587	0.0873
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0011	0.0011
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0011	0.0011
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0113	0.0206	0.0269
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Loa Loa (eye worm)	hypothetical protein	0.003	0.0017	0.0019
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0011	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0113	0.0206	0.0245
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0979	0.2191	0.3112
Brugia malayi	calpain family protein 1	0.0061	0.0089	0.0127
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0017	0.0017
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0113	0.0206	0.0269
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Entamoeba histolytica	hypothetical protein	0.0113	0.0206	0.0245
Brugia malayi	hypothetical protein	0.0028	0.0011	0.0016
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0154	0.03	0.0419
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.003	0.0017	0.0017
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0113	0.0206	0.0232
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0113	0.0206	0.0206
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0011	0.0011
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0011	0.0011
Trichomonas vaginalis	replication factor C large subunit, putative	0.0038	0.0036	0.00000023803

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 nM	Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme	ChEMBL.	14684298
IC50 (binding)	= 1 nM	Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme	ChEMBL.	14684298
MIC (functional)	< 0.125 ug ml-1	Minimum inhibitory concentration required for primary screening against in-house strain of Moraxella catarrhalis tested in vitro	ChEMBL.	14684298
MIC (functional)	< 0.5 ug ml-1	Minimum inhibitory concentration required for primary screening against in-house strain of Streptococcus pneumoniae tested in vitro; Range- 0.25-0.5	ChEMBL.	14684298
MIC (functional)	< 2 ug ml-1	Minimum inhibitory concentration required for primary screening against in-house strain of Haemophilus influenzae tested in vitro; Range- 0.25-2	ChEMBL.	14684298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL158092

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 268192