Detailed information for compound 268216

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 720.944 | Formula: C37H48N6O5S2
  • H donors: 4 H acceptors: 6 LogP: 5.98 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCN(C(=O)NC(C(=O)N[C@@H](Cc1ccccc1)C[C@@H]([C@H](Cc1ccccc1)NC(=O)OCc1cncs1)O)C)Cc1csc(n1)C(C)C
  • InChi: 1S/C37H48N6O5S2/c1-5-16-43(21-30-23-49-35(41-30)25(2)3)36(46)39-26(4)34(45)40-29(17-27-12-8-6-9-13-27)19-33(44)32(18-28-14-10-7-11-15-28)42-37(47)48-22-31-20-38-24-50-31/h6-15,20,23-26,29,32-33,44H,5,16-19,21-22H2,1-4H3,(H,39,46)(H,40,45)(H,42,47)/t26?,29-,32-,33-/m0/s1
  • InChiKey: JKMFVOIHHZUECY-DAPQWQJDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0044 0.0102
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0087 0.0239
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0087 0.0207
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0548 0.1445
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0017 0.0131
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0088 0.0855 0.2266
Loa Loa (eye worm) oxidoreductase 0.0304 0.3422 1
Trypanosoma cruzi aldo-keto reductase 0.0304 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.1167
Mycobacterium ulcerans oxidoreductase 0.0304 0.3422 1
Toxoplasma gondii aldose reductase, putative 0.0304 0.3422 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0304 0.3422 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0088 0.0855 0.2487
Onchocerca volvulus 0.0304 0.3422 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0044 0.0102
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0044 0.0038
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0548 0.1445
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Echinococcus granulosus aldo keto reductase 0.0304 0.3422 0.911
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0033
Loa Loa (eye worm) oxidoreductase 0.0304 0.3422 1
Entamoeba histolytica aldose reductase, putative 0.0304 0.3422 1
Echinococcus multilocularis aldehyde reductase 0.0216 0.2376 0.2371
Schistosoma mansoni aldo-keto reductase 0.0304 0.3422 0.911
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0261 0.068
Brugia malayi jmjC domain containing protein 0.0017 0.0006 0.0017
Mycobacterium leprae Conserved hypothetical protein 0.0216 0.2376 0.6861
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0239
Trichomonas vaginalis aldo/keto reductase, putative 0.0304 0.3422 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0044 0.0129
Schistosoma mansoni coup transcription factor 0.002 0.0044 0.0102
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0105 0.029
Entamoeba histolytica aldose reductase, putative 0.0304 0.3422 1
Brugia malayi jmjC domain containing protein 0.0017 0.0006 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0548 0.1445
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0044 0.0129
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Mycobacterium ulcerans hypothetical protein 0.0088 0.0855 0.2462
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0102
Schistosoma mansoni potassium channel beta 0.0088 0.0855 0.2266
Trichomonas vaginalis aldo/keto reductase, putative 0.0304 0.3422 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0105 0.1167
Brugia malayi MH2 domain containing protein 0.0116 0.1187 0.3467
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0088 0.0855 0.2487
Entamoeba histolytica hypothetical protein 0.0038 0.0261 0.052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0038
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0304 0.3422 1
Onchocerca volvulus 0.0088 0.0855 0.2402
Echinococcus multilocularis aldo keto reductase 0.0304 0.3422 0.3419
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Brugia malayi NADH-dependent xylose reductase 0.0088 0.0855 0.25
Entamoeba histolytica hypothetical protein 0.0038 0.0261 0.052
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Giardia lamblia Aldose reductase 0.0304 0.3422 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Brugia malayi steroid hormone receptor 0.002 0.0044 0.0129
Brugia malayi jmjC domain containing protein 0.0062 0.0548 0.1601
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0088 0.0855 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0548 0.1445
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0304 0.3422 1
Onchocerca volvulus 0.0304 0.3422 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0087 0.0207
Echinococcus multilocularis aldo keto reductase 0.0304 0.3422 0.3419
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1187 0.3456
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0087 0.0255
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0088 0.0855 0.2487
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0044 0.0102
Leishmania major hypothetical protein, conserved 0.0025 0.0105 0.029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0129
Mycobacterium tuberculosis Probable oxidoreductase 0.0304 0.3422 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0129
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0548 0.1445
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0304 0.3422 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0038
Echinococcus granulosus aldo keto reductase 0.0304 0.3422 0.911
Leishmania major aldo-keto reductase-like protein 0.0304 0.3422 1
Echinococcus granulosus aldo keto reductase 0.0304 0.3422 0.911
Onchocerca volvulus 0.0023 0.0087 0.0128
Schistosoma mansoni hypothetical protein 0.0332 0.3756 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0087 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0239
Brugia malayi ecdysteroid receptor 0.002 0.0044 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0129
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Entamoeba histolytica aldose reductase, putative 0.0304 0.3422 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Brugia malayi jmjC domain containing protein 0.0017 0.0006 0.0017
Schistosoma mansoni nuclear hormone receptor 0.002 0.0044 0.0102
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0087 0.0207
Onchocerca volvulus 0.0304 0.3422 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Schistosoma mansoni pol-related 0.0304 0.3422 0.911
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0044 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0087 0.0207
Mycobacterium tuberculosis Conserved protein 0.0088 0.0855 0.2487
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0261 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0112
Leishmania major prostaglandin f synthase, putative 0.0304 0.3422 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Mycobacterium ulcerans hypothetical protein 0.0023 0.0087 0.0207
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0087 0.0207
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Brugia malayi nuclear hormone receptor 0.002 0.0044 0.0129
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0044 0.0102
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0102
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0088 0.0855 0.2487
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0304 0.3422 1
Echinococcus granulosus hypothetical protein 0.0304 0.3422 0.911
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0087 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0044 0.0112
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0044 0.0102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0102
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0102
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0105 0.029
Loa Loa (eye worm) oxidoreductase 0.0304 0.3422 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.029
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0088 0.0855 0.25
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0129
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0044 0.0102
Trypanosoma brucei aldo/keto reductase, putative 0.0088 0.0855 0.2487
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0087 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0033
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0304 0.3422 1
Schistosoma mansoni hypothetical protein 0.0332 0.3756 1
Plasmodium vivax aldehyde reductase, putative 0.0088 0.0855 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1187 0.3456
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0044 0.0102
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.1167
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Loa Loa (eye worm) oxidoreductase 0.0304 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Brugia malayi hypothetical protein 0.0038 0.0261 0.0762
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0044 0.0129
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.029
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0548 0.1587
Echinococcus multilocularis geminin 0.0332 0.3756 0.3752
Trypanosoma cruzi aldo/keto reductase, putative 0.0304 0.3422 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0102
Echinococcus granulosus voltage gated potassium channel subunit 0.0088 0.0855 0.2266
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0088 0.0855 0.2487
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0548 0.0542
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0033
Echinococcus granulosus geminin 0.0332 0.3756 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0044 0.0038
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0044 0.0102
Schistosoma mansoni hypothetical protein 0.0038 0.0261 0.068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0044 0.0102
Trypanosoma brucei aldo-keto reductase, putative 0.0304 0.3422 1
Brugia malayi jmjC domain containing protein 0.0017 0.0006 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.029
Plasmodium falciparum aldehyde reductase, putative 0.0088 0.0855 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0304 0.3422 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Echinococcus granulosus aldehyde reductase 0.0216 0.2376 0.6319
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0304 0.3422 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0112
Entamoeba histolytica hypothetical protein 0.0038 0.0261 0.052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0044 0.0102
Echinococcus multilocularis aldo keto reductase 0.0304 0.3422 0.3419
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0087 0.0239
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0112
Onchocerca volvulus 0.0304 0.3422 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0304 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0112
Schistosoma mansoni aldo-keto reductase 0.0304 0.3422 0.911
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0548 0.0542
Brugia malayi jmjC domain containing protein 0.0062 0.0548 0.1601
Loa Loa (eye worm) oxidoreductase 0.0304 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0033
Echinococcus granulosus FTZ F1 alpha 0.002 0.0044 0.0102
Entamoeba histolytica alcohol dehydrogenase, putative 0.0088 0.0855 0.2303
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0044 0.0129
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0017 0.5
Brugia malayi nuclear receptor NHR-88 0.002 0.0044 0.0129
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0087 0.0207
Plasmodium falciparum aldo-keto reductase, putative 0.0088 0.0855 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0017 0.0131
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0044 0.0112
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0087 0.0255
Brugia malayi hypothetical protein 0.0025 0.0105 0.0307
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0044 0.0038
Echinococcus multilocularis aldo keto reductase 0.0304 0.3422 0.3419
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0017 0.0033
Mycobacterium leprae Possible oxidoreductase 0.0088 0.0855 0.2303
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0304 0.3422 1
Toxoplasma gondii aldo-keto reductase 0.0088 0.0855 0.2487
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Loa Loa (eye worm) hypothetical protein 0.0023 0.0087 0.0239
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0261 0.068
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0304 0.3422 0.3419
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0129
Onchocerca volvulus 0.0304 0.3422 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0087 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0044 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0129
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0304 0.3422 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.3422 1
Trypanosoma brucei prostaglandin f synthase 0.0304 0.3422 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0102
Echinococcus multilocularis voltage gated potassium channel subunit 0.0088 0.0855 0.085
Trichomonas vaginalis aldo-keto reductase, putative 0.0304 0.3422 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0088 0.0855 0.2303
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0304 0.3422 0.911
Entamoeba histolytica hypothetical protein 0.0038 0.0261 0.052
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0044 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0087 0.0239
Onchocerca volvulus 0.0304 0.3422 1
Giardia lamblia Aldose reductase 0.0304 0.3422 0.5

Activities

Activity type Activity value Assay description Source Reference
CCIC50 (ADMET) = 19 uM Cytotoxicity was determined against uninfected MT-4 cells ChEMBL. 9484509
EC50 (functional) = 0.14 uM Effective concentration required for the inhibition of HIV-1 IIIB in MT-4 cells ChEMBL. 9484509
Inhibition (binding) = 50 % Inhibition of purified recombinant HIV-1 protease at 0.5 nm using a fluorogenic substrate ChEMBL. 9484509
Inhibition (binding) = 50 % Inhibition of purified recombinant HIV-1 protease at 0.5 nm using a fluorogenic substrate ChEMBL. 9484509

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.