Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neprilysin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.1 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 34.1 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 778 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0066 | 0.0066 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Onchocerca volvulus | 0.0251 | 0.1235 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0251 | 0.1235 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.0264 | 0.0264 |
Brugia malayi | Carboxylesterase family protein | 0.1483 | 1 | 1 |
Onchocerca volvulus | 0.0251 | 0.1235 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1483 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0251 | 0.1235 | 0.1235 |
Echinococcus multilocularis | acetylcholinesterase | 0.1483 | 1 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | carboxylesterase | 0.0251 | 0.1235 | 0.1235 |
Echinococcus granulosus | carboxylesterase 5A | 0.1483 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0052 | 0.0052 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0251 | 0.1235 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.0264 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1235 | 0.1235 |
Onchocerca volvulus | 0.0251 | 0.1235 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0251 | 0.1235 | 0.1235 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0264 | 0.0264 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0251 | 0.1235 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.0264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.1483 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1483 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | carboxylesterase | 0.0251 | 0.1235 | 0.1235 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1483 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0251 | 0.1235 | 0.1235 |
Echinococcus granulosus | acetylcholinesterase | 0.1483 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0251 | 0.1235 | 0.1235 |
Echinococcus multilocularis | neuroligin | 0.0251 | 0.1235 | 0.1235 |
Onchocerca volvulus | 0.0251 | 0.1235 | 1 | |
Brugia malayi | Peptidase family M13 containing protein | 0.0114 | 0.0264 | 0.0264 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0264 | 0.0264 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0251 | 0.1235 | 0.1235 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0251 | 0.1235 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1483 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0251 | 0.1235 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0251 | 0.1235 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.0052 | 0.0052 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 0.0264 | 0.0264 |
Brugia malayi | Carboxylesterase family protein | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0066 | 0.0066 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0251 | 0.1235 | 0.1235 |
Echinococcus granulosus | neuroligin | 0.0251 | 0.1235 | 0.1235 |
Echinococcus multilocularis | acetylcholinesterase | 0.1483 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Echinococcus granulosus | acetylcholinesterase | 0.1483 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0251 | 0.1235 | 0.1235 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0251 | 0.1235 | 0.1235 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1235 | 0.1235 |
Schistosoma mansoni | acetylcholinesterase | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.1483 | 1 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.0264 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0264 | 0.0264 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0251 | 0.1235 | 0.1235 |
Onchocerca volvulus | 0.0251 | 0.1235 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.1235 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0066 | 0.0066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.4 nM | The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme | ChEMBL. | 1738153 |
IC50 (binding) | = 7.4 nM | The compound was tested in vitro for its inhibitory activity against Enkephalinase enzyme | ChEMBL. | 1738153 |
IC50 (binding) | = 37 uM | In vitro inhibitory activity against angiotensin I converting enzyme (ACE) from rabbit lung | ChEMBL. | 1738153 |
IC50 (binding) | = 37 uM | In vitro inhibitory activity against angiotensin I converting enzyme (ACE) from rabbit lung | ChEMBL. | 1738153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.