TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.553 | Formula: C25H35F3N2O2
H donors: 2 H acceptors: 2 LogP: 3.55 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.NCCCN(Cc1ccc(cc1)C(C)C)Cc1ccc(cc1)C(C)C
InChi: 1S/C23H34N2.C2HF3O2/c1-18(2)22-10-6-20(7-11-22)16-25(15-5-14-24)17-21-8-12-23(13-9-21)19(3)4;3-2(4,5)1(6)7/h6-13,18-19H,5,14-17,24H2,1-4H3;(H,6,7)
InChiKey: OVNIEXFSYDLGKZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.00176162	0.0635979	0.281159
Loa Loa (eye worm)	FKBP5 protein	0.0152163	0.992242	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.00134237	0.0346613	0.0349323
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.00441416	0.246677	0.243495
Schistosoma mansoni	retinoic acid receptor RXR	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	hypothetical protein	0.0027268	0.130215	0.131233
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.00441416	0.246677	0.221408
Trypanosoma cruzi	macrophage infectivity potentiator, precursor, putative	0.00134237	0.0346613	0.0283675
Schistosoma mansoni	protein phosphatase-2b	0.00291488	0.143197	0.137414
Echinococcus multilocularis	thyroid hormone receptor alpha	0.000988394	0.0102299	0.00354963
Trypanosoma cruzi	cytochrome P450, putative	0.00201163	0.080854	0.075238
Onchocerca volvulus		0.00373851	0.200044	1
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.00134237	0.0346613	0.0283675
Toxoplasma gondii	protease inhibitor PI2	0.00176162	0.0635979	0.294268
Toxoplasma gondii	target of rapamycin (TOR), putative	0.00336268	0.174104	0.865832
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0152163	0.992242	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.000988394	0.0102299	0.00357757
Echinococcus multilocularis	splicing factor 3b subunit 3	0.00373851	0.200044	0.194645
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0152163	0.992242	1
Leishmania major	fk506-binding protein 1-like protein	0.0152163	0.992242	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.00134237	0.0346613	0.0281459
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.00441416	0.246677	0.241593
Brugia malayi	Cytochrome P450 family protein	0.00201163	0.080854	0.075238
Echinococcus granulosus	agrin	0.00176162	0.0635979	0.0572778
Schistosoma mansoni	RAR-like nuclear receptor	0.000988394	0.0102299	0.00354963
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025225	0.116115	0.111016
Trichomonas vaginalis	conserved hypothetical protein	0.00134237	0.0346613	0.0283675
Loa Loa (eye worm)	agrin synaptic family protein	0.00176162	0.0635979	0.0640952
Echinococcus multilocularis	serine:threonine protein phosphatase 2B	0.00291488	0.143197	0.137414
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0152163	0.992242	1
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027268	0.130215	0.125324
Echinococcus granulosus	follistatin	0.00176162	0.0635979	0.0572778
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.00134237	0.0346613	0.0283675
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.00291488	0.143197	0.137414
Echinococcus granulosus	ecdysone induced protein 78C	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	hypothetical protein	0.00176162	0.0635979	0.0640952
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025225	0.116115	0.111016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00336268	0.174104	0.169856
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.000988394	0.0102299	0.00354963
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00176162	0.0635979	0.0577287
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.000988394	0.0102299	0.00354963
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00366394	0.194897	0.190955
Brugia malayi	secreted modular calcium-binding protein 1	0.00176162	0.0635979	0.0577287
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.00441416	0.246677	0.241593
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.000988394	0.0102299	0.00354963
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025277	0.116474	0.11138
Loa Loa (eye worm)	hypothetical protein	0.00291488	0.143197	0.144316
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.000988394	0.0102299	0.00357757
Loa Loa (eye worm)	hypothetical protein	0.0138745	0.899632	0.906666
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.00134237	0.0346613	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.00201163	0.080854	0.048239
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.00291488	0.143197	0.137414
Brugia malayi	Serine/threonine protein phosphatase 2B catalytic subunit 2	0.00291488	0.143197	0.138496
Leishmania major	phosphatidylinositol 3-kinase, putative	0.00168753	0.0584842	0.0248783
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Echinococcus granulosus	serine:threonine protein phosphatase 2B	0.00291488	0.143197	0.137414
Trypanosoma brucei	protein phosphatase 2B, putative	0.00291488	0.143197	0.138496
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	phosphatidylinositol 3	0.00441416	0.246677	0.248606
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00357918	0.189047	0.185019
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.00134237	0.0346613	0.144601
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0153287	1	1
Trypanosoma brucei	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.00134237	0.0346613	0.0283675
Entamoeba histolytica	Ser/Thr protein phosphatase, putative	0.00291488	0.143197	0.137414
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.000988394	0.0102299	0.0103099
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0027268	0.130215	0.124345
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0152163	0.992242	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.000988394	0.0102299	0.00354963
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.00441416	0.246677	0.243495
Echinococcus multilocularis	FTZ F1 alpha	0.000988394	0.0102299	0.00354963
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.00441416	0.246677	0.241593
Loa Loa (eye worm)	hypothetical protein	0.0027268	0.130215	0.131233
Schistosoma mansoni	immunophilin	0.0139863	0.907349	0.906724
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.00134237	0.0346613	0.0281459
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0027268	0.130215	0.124345
Trypanosoma brucei	macrophage infectivity potentiator, precursor, putative	0.00134237	0.0346613	0.0283675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00292544	0.143925	0.139235
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.000988394	0.0102299	0.00354963
Onchocerca volvulus		0.0027268	0.130215	0.63212
Schistosoma mansoni	thyroid hormone receptor	0.000988394	0.0102299	0.00354963
Schistosoma mansoni	protein phosphatase-2b	0.00291488	0.143197	0.137414
Brugia malayi	Nuclear hormone receptor-like 1	0.000988394	0.0102299	0.00357757
Plasmodium falciparum	splicing factor 3B subunit 3, putative	0.00373851	0.200044	0.172709
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.00291488	0.143197	0.137414
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0152163	0.992242	0.992189
Brugia malayi	photoreceptor-specific nuclear receptor	0.000988394	0.0102299	0.00357757
Brugia malayi	prostaglandin transporter	0.0027268	0.130215	0.125324
Loa Loa (eye worm)	hypothetical protein	0.0027268	0.130215	0.131233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00168753	0.0584842	0.05254
Echinococcus multilocularis	agrin	0.00176162	0.0635979	0.0572778
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.00176162	0.0635979	0.294268
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.000988394	0.0102299	0.00357757
Schistosoma mansoni	agrin	0.00176162	0.0635979	0.0572778
Echinococcus multilocularis	serine:threonine protein phosphatase 2B	0.00291488	0.143197	0.137414
Schistosoma mansoni	follistatin	0.00176162	0.0635979	0.0572778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00357918	0.189047	0.185019
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00176162	0.0635979	0.0577287
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0153287	1	1
Brugia malayi	hypothetical protein	0.0027268	0.130215	0.125324
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.00176162	0.0635979	0.0640952
Trichomonas vaginalis	fk506-binding protein, putative	0.0152163	0.992242	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.00195872	0.077202	0.0715325
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.00134237	0.0346613	0.0281459
Echinococcus multilocularis	expressed protein	0.00176162	0.0635979	0.0572778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00336268	0.174104	0.169856
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00168753	0.0584842	0.05254
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0152163	0.992242	1
Leishmania major	peptidylprolyl isomerase-like protein	0.0152163	0.992242	1
Loa Loa (eye worm)	hypothetical protein	0.00093731	0.00670406	0.00675648
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0152163	0.992242	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.00168753	0.0584842	0.0589415
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0153287	1	1
Trichomonas vaginalis	fk506 binding protein, putative	0.00134237	0.0346613	0.0283675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00336268	0.174104	0.169856
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00168753	0.0584842	0.05254
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00261247	0.122324	0.117316
Giardia lamblia	GTOR	0.00441416	0.246677	0.221408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00168753	0.0584842	0.05254
Trypanosoma cruzi	serine/threonine protein phosphatase 2B catalytic subunit A2, putative	0.00291488	0.143197	0.138496
Plasmodium vivax	serine/threonine protein phosphatase 2B catalytic subunit A, putative	0.00291488	0.143197	0.113343
Onchocerca volvulus		0.0027268	0.130215	0.63212
Schistosoma mansoni	thyroid hormone receptor	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	CYP4Cod1	0.00201163	0.080854	0.0814862
Echinococcus multilocularis	follistatin	0.00176162	0.0635979	0.0572778
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0027268	0.130215	0.131233
Onchocerca volvulus	Putative organic anion transporter	0.0027268	0.130215	0.63212
Schistosoma mansoni	organic anion transporter	0.0027268	0.130215	0.124345
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0152163	0.992242	1
Brugia malayi	nuclear receptor NHR-88	0.000988394	0.0102299	0.00357757
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0152163	0.992242	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.00168753	0.0584842	0.05254
Onchocerca volvulus		0.00134237	0.0346613	0.128712
Trypanosoma brucei	hypothetical protein, conserved	0.00134237	0.0346613	0.0283675
Echinococcus granulosus	FTZ F1 alpha	0.000988394	0.0102299	0.00354963
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00273901	0.131058	0.126178
Brugia malayi	nuclear hormone receptor	0.000988394	0.0102299	0.00357757
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.00168753	0.0584842	0.0521296
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.000988394	0.0102299	0.00357757
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027268	0.130215	0.125324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00261247	0.122324	0.117316
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.000988394	0.0102299	0.0103099
Loa Loa (eye worm)	hypothetical protein	0.00103378	0.0133625	0.013467
Echinococcus granulosus	FK506 binding protein 2	0.00134237	0.0346613	0.0281459
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.000988394	0.0102299	0.00354963
Schistosoma mansoni	immunophilin	0.0153287	1	1
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.00145478	0.0424198	0.0359568
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0027268	0.130215	0.124345
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0152163	0.992242	1
Trichomonas vaginalis	conserved hypothetical protein	0.00103378	0.0133625	0.00675617
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.00134237	0.0346613	0.0283675
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	hypothetical protein	0.00176162	0.0635979	0.0640952
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.00176162	0.0635979	0.294268
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0152163	0.992242	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.000988394	0.0102299	0.00354963
Onchocerca volvulus		0.0027268	0.130215	0.63212
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0139863	0.907349	0.906724
Loa Loa (eye worm)	hypothetical protein	0.00176162	0.0635979	0.0640952
Onchocerca volvulus		0.0027268	0.130215	0.63212
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.000988394	0.0102299	0.00354963
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00176162	0.0635979	0.0577287
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Schistosoma mansoni	organic anion transporter	0.0027268	0.130215	0.124345
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.000988394	0.0102299	0.0103099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00357918	0.189047	0.185019
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00336268	0.174104	0.169856
Echinococcus multilocularis		0.00134237	0.0346613	0.0281459
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0152163	0.992242	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.000988394	0.0102299	0.0103099
Trypanosoma brucei	cytochrome P450, putative	0.00201163	0.080854	0.075238
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.000988394	0.0102299	0.00354963
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.00134237	0.0346613	0.0283675
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.00134237	0.0346613	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.000988394	0.0102299	0.00357757
Trichomonas vaginalis	immunophilin, putative	0.0152163	0.992242	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.000988394	0.0102299	0.00357757
Loa Loa (eye worm)	hypothetical protein	0.0027268	0.130215	0.131233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00273901	0.131058	0.126178
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.00168753	0.0584842	0.0521296
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0152163	0.992242	1
Brugia malayi	sodium-independent organic anion transporter family protein	0.0027268	0.130215	0.125324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00441416	0.246677	0.243495
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.00357398	0.188688	0.16085
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Brugia malayi	ecdysteroid receptor	0.000988394	0.0102299	0.00357757
Trichomonas vaginalis	spliceosomal protein sap, putative	0.00373851	0.200044	0.196177
Schistosoma mansoni	immunophilin	0.0153287	1	1
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.00134237	0.0346613	0.5
Entamoeba histolytica	Ser/Thr protein phosphatase, putative	0.00291488	0.143197	0.137414
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.00134237	0.0346613	0.0283675
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.00441416	0.246677	0.241593
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00357918	0.189047	0.185019
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.00168753	0.0584842	0.05254
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025277	0.116474	0.11138
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.00134237	0.0346613	0.0349323
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.00134237	0.0346613	0.144601
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0152163	0.992242	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.000988394	0.0102299	0.00357757
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00336268	0.174104	0.169856
Loa Loa (eye worm)	hypothetical protein	0.0027268	0.130215	0.131233
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.00134237	0.0346613	0.0283675
Trypanosoma cruzi	serine/threonine protein phosphatase, putative	0.00291488	0.143197	0.138496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00261247	0.122324	0.117316
Trypanosoma cruzi	serine/threonine protein phosphatase, putative	0.00291488	0.143197	0.138496
Schistosoma mansoni	fk506 binding protein	0.00134237	0.0346613	0.0281459
Onchocerca volvulus		0.0027268	0.130215	0.63212
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Schistosoma mansoni	coup transcription factor	0.000988394	0.0102299	0.00354963
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.00291488	0.143197	0.137414
Onchocerca volvulus	Putative organic anion transporter	0.0027268	0.130215	0.63212
Brugia malayi	steroid hormone receptor	0.000988394	0.0102299	0.00357757
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00336268	0.174104	0.169856
Brugia malayi	splicing factor 3B subunit 3	0.00373851	0.200044	0.196177
Plasmodium vivax	splicing factor 3B subunit 3, putative	0.00373851	0.200044	0.172709
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.00176162	0.0635979	0.294268
Plasmodium falciparum	serine/threonine protein phosphatase 2B catalytic subunit A	0.00291488	0.143197	0.113343
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00336268	0.174104	0.169856
Mycobacterium tuberculosis	Probable trigger factor (TF) protein Tig	0.00134237	0.0346613	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00357918	0.189047	0.185019
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00441416	0.246677	0.243495
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.00103378	0.0133625	0.0344391
Schistosoma mansoni	hypothetical protein	0.00134237	0.0346613	0.0281459
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.000988394	0.0102299	0.00357757
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.000988394	0.0102299	0.00354963
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0152163	0.992242	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00441416	0.246677	0.243495
Leishmania major	serine/threonine protein phosphatase, putative	0.00291488	0.143197	0.113343
Echinococcus multilocularis	fk506 binding protein	0.0152163	0.992242	0.992189
Loa Loa (eye worm)	cytochrome P450 family protein	0.00201163	0.080854	0.0814862
Leishmania major	cytochrome p450-like protein	0.00201163	0.080854	0.048239
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.00134237	0.0346613	0.0283675
Loa Loa (eye worm)	hypothetical protein	0.000988394	0.0102299	0.0103099
Loa Loa (eye worm)	hypothetical protein	0.00176162	0.0635979	0.0640952
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.000988394	0.0102299	0.0103099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025277	0.116474	0.11138
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.000988394	0.0102299	0.00354963
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.00168753	0.0584842	0.0521296
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0152163	0.992242	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0153287	1	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.00441416	0.246677	0.243495
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0152163	0.992242	0.992189
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.00168753	0.0584842	0.05254
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.00186876	0.0709928	0.0652322
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.00134237	0.0346613	0.144601
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.000988394	0.0102299	0.00357757
Mycobacterium leprae	PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	0.00134237	0.0346613	0.5
Schistosoma mansoni	nuclear hormone receptor	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	hypothetical protein	0.00373851	0.200044	0.201608
Toxoplasma gondii	transporter, major facilitator family protein	0.0027268	0.130215	0.638829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025225	0.116115	0.111016
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.00441416	0.246677	0.243495
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.000988394	0.0102299	0.00354963
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0152163	0.992242	1
Brugia malayi	SPARC precursor	0.00176162	0.0635979	0.0577287
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.000988394	0.0102299	0.00354963
Loa Loa (eye worm)	hypothetical protein	0.00291457	0.143175	0.144295
Echinococcus granulosus	splicing factor 3b subunit 3	0.00373851	0.200044	0.194645
Trypanosoma cruzi	cytochrome P450, putative	0.00201163	0.080854	0.075238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00112374	0.0195717	0.0130565
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.000988394	0.0102299	0.0103099
Trypanosoma cruzi	target of rapamycin kinase 3	0.00357398	0.188688	0.184654
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.00168753	0.0584842	0.05254
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0152163	0.992242	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00282897	0.137267	0.132479
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.00134237	0.0346613	0.144601
Brugia malayi	Cytochrome P450 family protein	0.00201163	0.080854	0.075238
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.000988394	0.0102299	0.00357757
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.000988394	0.0102299	0.00354963
Toxoplasma gondii	protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein	0.00291488	0.143197	0.705972
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.00134237	0.0346613	0.0349323
Toxoplasma gondii	splicing factor 3b, subunit 3, putative	0.00373851	0.200044	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.000988394	0.0102299	0.00354963
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.00176162	0.0635979	0.0577287
Brugia malayi	Steroid receptor seven-up type 2	0.000988394	0.0102299	0.00357757
Schistosoma mansoni	steroid hormone receptor ad4bp	0.000988394	0.0102299	0.00354963
Trichomonas vaginalis	PIKK family atypical protein kinase	0.00168753	0.0584842	0.05254
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.00168753	0.0584842	0.05254
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0139863	0.907349	0.906724
Trichomonas vaginalis	fk506-binding protein, putative	0.00134237	0.0346613	0.0283675
Loa Loa (eye worm)	cytochrome P450 family protein	0.00201163	0.080854	0.0814862
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.00441416	0.246677	0.243495
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.00176162	0.0635979	0.294268
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.000988394	0.0102299	0.00357757
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.00441416	0.246677	0.241593
Onchocerca volvulus		0.00134237	0.0346613	0.128712
Loa Loa (eye worm)	hypothetical protein	0.0027268	0.130215	0.131233
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0027268	0.130215	0.124345
Loa Loa (eye worm)	hypothetical protein	0.0027268	0.130215	0.131233
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.000988394	0.0102299	0.00357757
Trichomonas vaginalis	conserved hypothetical protein	0.00134237	0.0346613	0.0283675
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.00441416	0.246677	0.221408
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.00357398	0.188688	0.184654
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.000988394	0.0102299	0.0103099
Echinococcus granulosus	serine:threonine protein phosphatase 2B	0.00291488	0.143197	0.137414
Leishmania major	serine/threonine protein phosphatase 2B catalytic subunit A2, putative	0.00291488	0.143197	0.113343
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.00134237	0.0346613	0.0283675
Loa Loa (eye worm)	steroid hormone receptor	0.000988394	0.0102299	0.0103099
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.000988394	0.0102299	0.00357757
Trichomonas vaginalis	fk506-binding protein, putative	0.00134237	0.0346613	0.0283675
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.00168753	0.0584842	0.0248783
Onchocerca volvulus	Putative organic anion transporter	0.0027268	0.130215	0.63212
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025225	0.116115	0.111016
Brugia malayi	hypothetical protein	0.0027268	0.130215	0.125324
Trypanosoma cruzi	MFS transporter, putative	0.0027268	0.130215	0.125324
Loa Loa (eye worm)	hypothetical protein	0.00131944	0.0330789	0.0333376
Loa Loa (eye worm)	hypothetical protein	0.00134237	0.0346613	0.0349323
Entamoeba histolytica	CPSF A subunit region protein, putative	0.00373851	0.200044	0.194645

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	uM	Antiparasitic activity against malaria parasite Plasmodium falciparum D6	ChEMBL.	14741254
EC50 (functional)	NA 0 uM	Antiparasitic activity against malaria parasite Plasmodium falciparum D6	ChEMBL.	14741254
EC50 (functional)	= 2.65 uM	Antiparasitic activity against Leishmania promastigotes (Leishmania donovani)	ChEMBL.	14741254
EC50 (functional)	= 9.5 uM	Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain	ChEMBL.	14741254
EC50 (functional)	= 9.5 uM	Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain	ChEMBL.	14741254

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	14741254

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL157498

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 268268