Detailed information for compound 268271

Basic information

Technical information
  • TDR Targets ID: 268271
  • Name: 1-cyclobutyl-1-hydroxy-3-[4-(2-methylprop-2-e nyl)piperazin-1-yl]-1-phenylpropan-2-one
  • MW: 342.475 | Formula: C21H30N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccc1)(C1CCC1)O)CN1CCN(CC1)CC(=C)C
  • InChi: 1S/C21H30N2O2/c1-17(2)15-22-11-13-23(14-12-22)16-20(24)21(25,19-9-6-10-19)18-7-4-3-5-8-18/h3-5,7-8,19,25H,1,6,9-16H2,2H3
  • InChiKey: BRCPZJDCSAYHDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclobutyl-1-hydroxy-3-[4-(2-methylallyl)piperazin-1-yl]-1-phenyl-propan-2-one
  • 1-cyclobutyl-1-hydroxy-3-[4-(2-methylallyl)-1-piperazinyl]-1-phenyl-2-propanone
  • 1-cyclobutyl-1-hydroxy-3-[4-(2-methylprop-2-enyl)piperazin-1-yl]-1-phenyl-propan-2-one
  • 1-cyclobutyl-1-hydroxy-3-[4-(2-methylallyl)piperazino]-1-phenyl-acetone
  • 1-cyclobutyl-1-hydroxy-3-[4-(2-methylprop-2-enyl)-1-piperazinyl]-1-phenylpropan-2-one
  • 1-cyclobutyl-1-hydroxy-3-[4-(2-methylprop-2-enyl)piperazin-1-yl]-1-phenyl-acetone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0317 1
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Brugia malayi G-protein coupled receptor 0.0047 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0317 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0317 1
Brugia malayi AKH receptor 0.0047 0.0317 0.0317
Brugia malayi sulfakinin receptor protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis serotonin receptor 0.0047 0.0317 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0317 0.0317
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0317 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0317 1
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0317 0.0317
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0317 1
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0317 1
Echinococcus multilocularis somatostatin receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Onchocerca volvulus 0.0047 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi FAD binding domain containing protein 0.0022 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0317 1
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0317 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0317 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus g protein coupled receptor 0.0047 0.0317 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0317 1
Echinococcus granulosus somatostatin receptor 0.0047 0.0317 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0317 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0317 1
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0317 1
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0317 0.0317
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0317 0.0317
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0317 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Giardia lamblia Hypothetical protein 0.002 0.0057 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0317 1
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0415 0.3849 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0317 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Onchocerca volvulus 0.0047 0.0317 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Trichomonas vaginalis sulfite reductase, putative 0.0022 0.0081 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0317 1
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0317 0.0317
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0317 1
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus hypothetical protein 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi flavodoxin family protein 0.0022 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Onchocerca volvulus 0.0047 0.0317 0.5
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0317 1
Brugia malayi ORL1-like opioid receptor 0.0047 0.0317 0.0317
Echinococcus granulosus allatostatin A receptor 0.0047 0.0317 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0317 1
Schistosoma mansoni amine GPCR 0.0047 0.0317 1
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0317 1
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0317 1
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0317 1
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0022 0.0081 0.5
Echinococcus granulosus serotonin receptor 0.0047 0.0317 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0317 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0317 0.5
Brugia malayi Dopamine receptor protein 2 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0317 1
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0317 0.0317
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus orexin receptor type 2 0.0047 0.0317 1
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0022 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Schistosoma mansoni myosin xvIII 0.0047 0.0317 1
Echinococcus multilocularis serotonin receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi Dopamine receptor protein 1 0.0047 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0317 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0317 0.0317
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0317 1
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0317 0.0317
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Onchocerca volvulus 0.0047 0.0317 0.5
Onchocerca volvulus 0.0047 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.1057 1 1
Brugia malayi Serotonin receptor 0.0047 0.0317 0.0317
Schistosoma mansoni amine GPCR 0.0047 0.0317 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0317 1
Schistosoma mansoni cytochrome P450 reductase 0.0022 0.0081 0.2568
Brugia malayi Serotonin receptor 0.0047 0.0317 0.0317
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Leishmania major malonyl-coa decarboxylase-like protein 0.0415 0.3849 1
Echinococcus granulosus g protein coupled receptor 0.0047 0.0317 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus sex peptide receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Schistosoma mansoni biogenic amine receptor 0.0047 0.0317 1
Schistosoma mansoni neuropeptide receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0317 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Brugia malayi G protein-coupled receptor 0.0047 0.0317 0.0317
Schistosoma mansoni neuropeptide receptor 0.0047 0.0317 1
Brugia malayi neuropeptide F receptor 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0317 1
Schistosoma mansoni neuropeptide receptor 0.0047 0.0317 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Schistosoma mansoni opsin-like receptor 0.0047 0.0317 1
Schistosoma mansoni neuropeptide receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Schistosoma mansoni hypothetical protein 0.0047 0.0317 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0022 0.0081 0.2568
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0317 1
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis sex peptide receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0317 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0317 1
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0022 0.0081 0.0064
Chlamydia trachomatis sulfite reductase 0.0014 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0317 1
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) FAD binding domain-containing protein 0.0022 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0317 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0317 0.0317
Schistosoma mansoni biogenic amine receptor 0.0047 0.0317 1
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0317 1
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0317 1
Brugia malayi RE15519p 0.0047 0.0317 0.0317
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0317 1
Schistosoma mansoni biogenic amine receptor 0.0047 0.0317 1
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0317 1
Echinococcus granulosus fmrfamide receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0317 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0317 1
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0317 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0317 1
Brugia malayi Dopamine receptor 0.0047 0.0317 0.0317
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0317 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0317 1
Schistosoma mansoni hypothetical protein 0.0047 0.0317 1
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0022 0.0081 0.2568
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0317 0.0317
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0317 1
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0317 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0317 0.0317
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0317 1
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Schistosoma mansoni amine GPCR 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0022 0.0081 0.2568
Brugia malayi neuropeptide F receptor 0.0047 0.0317 0.0317
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0317 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0317 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0317 1
Schistosoma mansoni opsin-like receptor 0.0047 0.0317 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0317 1
Giardia lamblia Nitric oxide synthase, inducible 0.002 0.0057 0.5
Plasmodium falciparum nitric oxide synthase, putative 0.0022 0.0081 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0317 0.0317
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0317 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0317 1
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0317 1
Schistosoma mansoni hypothetical protein 0.0047 0.0317 1
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0317 1
Leishmania major p450 reductase, putative 0.0022 0.0081 0.0064
Brugia malayi G-protein coupled receptor 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Schistosoma mansoni adenoreceptor 0.0047 0.0317 1
Echinococcus granulosus g protein coupled receptor 0.0047 0.0317 1
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.1057 1 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0317 1
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0022 0.0081 0.2568
Onchocerca volvulus 0.0047 0.0317 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0317 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0317 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0317 1
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0317 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0317 1
Schistosoma mansoni amine GPCR 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0317 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0317 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0317 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0415 0.3849 1
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0415 0.3849 1
Schistosoma mansoni histamine h1 receptor 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0317 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Echinococcus granulosus neuropeptide receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Brugia malayi hypothetical protein 0.0047 0.0317 0.0317
Brugia malayi GnHR receptor homolog 0.0047 0.0317 0.0317
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0047 0.0317 1
Brugia malayi Melatonin receptor type 1A 0.0047 0.0317 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0317 1
Brugia malayi larval opioid receptor 0.0047 0.0317 0.0317
Echinococcus granulosus neuropeptide receptor 0.0047 0.0317 1
Brugia malayi putative neuropeptide receptor 0.0047 0.0317 0.0317
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0317 1
Schistosoma mansoni amine GPCR 0.0047 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0317 0.0317
Schistosoma mansoni opsin-like receptor 0.0047 0.0317 1
Onchocerca volvulus 0.0047 0.0317 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0317 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0317 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2.1 mg kg-1 In vivo antimuscarinic activity in guinea pig cystometrogram (CMG) model ChEMBL. 8496940
ED50 (functional) = 2.1 mg kg-1 In vivo antimuscarinic activity in guinea pig cystometrogram (CMG) model ChEMBL. 8496940
ED50 (functional) = 17 mg kg-1 In vivo antimuscarinic activity to decrease carbachol-stimulated salivation in guinea pig ChEMBL. 8496940
ED50 (functional) = 17 mg kg-1 In vivo antimuscarinic activity to decrease carbachol-stimulated salivation in guinea pig ChEMBL. 8496940
ED50 (functional) = 31 mg kg-1 In vivo antimuscarinic activity evaulated for its liability to cause mydriasis in guinea pig ChEMBL. 8496940
ED50 (functional) = 31 mg kg-1 In vivo antimuscarinic activity evaulated for its liability to cause mydriasis in guinea pig ChEMBL. 8496940
Kb (functional) = 54 nM Antagonist activity against muscarinic M1 receptor from rabbit vas deferens ChEMBL. 8496940
Kb (functional) = 54 nM Antagonist activity against muscarinic M1 receptor from rabbit vas deferens ChEMBL. 8496940
Kb (functional) = 100 nM Antagonist activity against muscarinic M3 receptor from guinea pig ileum ChEMBL. 8496940
Kb (functional) = 100 nM Antagonist activity against muscarinic M3 receptor from guinea pig ileum ChEMBL. 8496940
Kb (functional) = 551 nM Antagonist activity against muscarinic M2 receptor from guinea pig atria ChEMBL. 8496940
Kb (functional) = 551 nM Antagonist activity against muscarinic M2 receptor from guinea pig atria ChEMBL. 8496940

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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