Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0732 | 0.9641 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0732 | 0.9641 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.013 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0153 | 0.0359 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0153 | 0.0359 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0 mg kg-1 | Evaluated in vivo for reserpine hypothermia after oral administration of the compound in mouse. Minimum active dose was reported; 30-70%reduction | ChEMBL. | 6716399 |
HYPO (functional) | > 20 mg kg-1 | Evaluated for antagonism of reserpine induced hypothermia | ChEMBL. | 6716399 |
HYPO (functional) | > 20 mg kg-1 | Evaluated for antagonism of reserpine induced hypothermia | ChEMBL. | 6716399 |
LD50 (ADMET) | = 200 mg kg-1 | Lethal dose in mouse, in groups of ten | ChEMBL. | 6716399 |
LD50 (ADMET) | = 200 mg kg-1 | Lethal dose in mouse, in groups of ten | ChEMBL. | 6716399 |
Log k' (ADMET) | = 1.06 | HPLC capacity factor (k') | ChEMBL. | 6716399 |
Loss of righting reflex (functional) | = 70 | Righting ability was determined in mice before rapid rolling (unaroused) | ChEMBL. | 6716399 |
Mouse behavior activity (functional) | D 0 | Mouse behavior activity was determined;D= Depressant | ChEMBL. | 6716399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.