Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.2608 | 0.2608 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0178 | 0.9576 | 0.9576 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.2608 | 0.2608 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0178 | 0.9576 | 0.9576 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0178 | 0.9576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.9347 | 0.9347 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0178 | 0.9576 | 0.9576 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0178 | 0.9576 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0178 | 0.9576 | 0.9108 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Onchocerca volvulus | 0.0063 | 0.2608 | 1 | |
Echinococcus granulosus | dual specificity | 0.0185 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0178 | 0.9576 | 0.9108 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0178 | 0.9576 | 0.9576 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.2608 | 0.2608 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0178 | 0.9576 | 0.9108 |
Giardia lamblia | Kinase, CMGC CDK | 0.0178 | 0.9576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.2608 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0107 | 0.5249 | 0.5249 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0185 | 1 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0185 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0185 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0185 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0178 | 0.9576 | 0.9108 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.8914 | 0.8914 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0107 | 0.5249 | 0.5481 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.2608 | 0.2608 |
Onchocerca volvulus | 0.0063 | 0.2608 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.2608 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.2608 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.8914 | 0.8914 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0178 | 0.9576 | 0.9576 |
Brugia malayi | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Brugia malayi | cell division control protein 2 homolog | 0.0178 | 0.9576 | 0.9576 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0107 | 0.5249 | 0.5249 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.2608 | 0.2608 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0107 | 0.5249 | 0.5249 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0107 | 0.5249 | 0.5481 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0178 | 0.9576 | 0.9576 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0178 | 0.9576 | 0.9108 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Plasmodium vivax | protein kinase Crk2 | 0.0178 | 0.9576 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0178 | 0.9576 | 0.9576 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.5249 | 0.5249 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0178 | 0.9576 | 0.9576 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0178 | 0.9576 | 0.9108 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0178 | 0.9576 | 0.9108 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9771 | 0.9771 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.2608 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0178 | 0.9576 | 0.9576 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.2608 | 0.2608 |
Echinococcus granulosus | geminin | 0.0167 | 0.8914 | 0.8914 |
Echinococcus granulosus | cyclin dependent kinase | 0.0178 | 0.9576 | 0.9576 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.8914 | 0.8914 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0107 | 0.5249 | 0.5249 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0178 | 0.9576 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.2608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.2608 | 0.2608 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0178 | 0.9576 | 0.9576 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.2608 | 0.2608 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0107 | 0.5249 | 0.5249 |
Plasmodium falciparum | protein kinase 5 | 0.0178 | 0.9576 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0107 | 0.5249 | 0.5249 |
Entamoeba histolytica | protein kinase, putative | 0.0185 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0178 | 0.9576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.9771 | 0.9771 |
Onchocerca volvulus | 0.0063 | 0.2608 | 1 | |
Brugia malayi | Peroxidasin | 0.0063 | 0.2608 | 0.2608 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.2608 | 0.2608 |
Giardia lamblia | Kinase, CMGC CDK | 0.0178 | 0.9576 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0178 | 0.9576 | 0.9576 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.2608 | 0.2608 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0178 | 0.9576 | 0.9108 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.2608 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0178 | 0.9576 | 0.9576 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0185 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0178 | 0.9576 | 0.9576 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2608 | 0.2608 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 uM | In vitro inhibitory activity against prostaglandin G/H synthase 2 stably transfected in Chinese hamster ovary (CHO) cells | ChEMBL. | 12639538 |
IC50 (binding) | > 5 uM | In vitro inhibitory activity against prostaglandin G/H synthase 2 stably transfected in Chinese hamster ovary (CHO) cells | ChEMBL. | 12639538 |
IC50 (binding) | > 10 uM | In vitro inhibitory activity against sensitive U-937 microsomal prostaglandin G/H synthase 1 | ChEMBL. | 12639538 |
IC50 (binding) | > 10 uM | In vitro inhibitory activity against sensitive U-937 microsomal prostaglandin G/H synthase 1 | ChEMBL. | 12639538 |
IC50 (binding) | > 33 uM | In vitro inhibitory activity against prostaglandin G/H synthase 2 stably transfected in Human whole blood (HWB) cell | ChEMBL. | 12639538 |
IC50 (binding) | > 33 uM | In vitro inhibitory activity against prostaglandin G/H synthase 2 stably transfected in Human whole blood (HWB) cell | ChEMBL. | 12639538 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.