Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thioredoxin reductase | 0.0411 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0411 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0142 | 0.2506 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0142 | 0.2506 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0411 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0142 | 0.2506 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0411 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0142 | 0.2506 | 0.1234 |
Toxoplasma gondii | thioredoxin reductase | 0.0411 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0142 | 0.2506 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0411 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0411 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0411 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0411 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0411 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0411 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0142 | 0.2506 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0142 | 0.2506 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0411 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0142 | 0.2506 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0142 | 0.2506 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0142 | 0.2506 | 0.5 |
Leishmania major | trypanothione reductase | 0.0411 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0411 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0142 | 0.2506 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0142 | 0.2506 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | > 1000 mg kg-1 | Compound was tested for the toxic effect in mice after intraperitoneal injection | ChEMBL. | 2537425 |
LD50 (ADMET) | > 1000 mg kg-1 | Compound was tested for the toxic effect in mice after intraperitoneal injection | ChEMBL. | 2537425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.