Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0106 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 1 | 1 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.0106 | 1 | 0.5 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0106 | 1 | 0.5 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.0106 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0106 | 1 | 1 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0106 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.0106 | 1 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0106 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.9412 | 0.9412 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.0106 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.0106 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0 | 0.5 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0106 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0 | 0.5 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0106 | 1 | 0.5 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0106 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0 | 0.5 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0106 | 1 | 1 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.0106 | 1 | 0.5 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.0106 | 1 | 0.5 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0106 | 1 | 1 |
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.0106 | 1 | 1 |
Schistosoma mansoni | transcription factor | 0.0101 | 0.9412 | 0.9412 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0106 | 1 | 0.5 |
Echinococcus granulosus | Msx-like | 0.0101 | 0.9412 | 0.9412 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0106 | 1 | 0.5 |
Loa Loa (eye worm) | acyltransferase | 0.0106 | 1 | 1 |
Echinococcus multilocularis | homeobox | 0.0101 | 0.9412 | 0.9412 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.0106 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clearance (ADMET) | = 13 ml min-1 g-1 | Plasama clearance of the compound was determined in rat | ChEMBL. | No reference |
Cmax (ADMET) | = 7.2 uM | Maximum concentration of the compound at 4 hr after administration of 5 mg/kg dose peroral in rat | ChEMBL. | No reference |
ED50 (functional) | = 1 mg kg-1 | Intrinsic activity of the compound was determined in the rat pyresis assay | ChEMBL. | No reference |
ED50 (functional) | = 1.7 mg kg-1 | Intrinsic activity of the compound was determined in the rat paw edema model | ChEMBL. | No reference |
F (ADMET) | ~ 100 % | Bioavailability of the compound was determined at 4 hr after administration of 5 mg/kg dose peroral in rat | ChEMBL. | No reference |
IC50 (binding) | = 2 | Inhibition of COX2 (unknown origin) expressed in CHO cells | ChEMBL. | No reference |
IC50 (binding) | = 0.01 uM | Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells | ChEMBL. | No reference |
IC50 (binding) | = 0.01 uM | Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells | ChEMBL. | No reference |
IC50 (binding) | = 2.3 uM | In vivo ability to inhibit Prostaglandin G/H synthase 2 in human whole blood assay | ChEMBL. | No reference |
IC50 (binding) | = 2.3 uM | In vivo ability to inhibit Prostaglandin G/H synthase 2 in human whole blood assay | ChEMBL. | No reference |
IC50 (binding) | = 43 uM | Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells | ChEMBL. | No reference |
IC50 (binding) | = 43 uM | Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells | ChEMBL. | No reference |
ID50 (functional) | = 1 mg kg-1 | Intrinsic activity of the compound was determined in the rat hyperalgesia assay | ChEMBL. | No reference |
Ratio (binding) | = 4300 | Selectivity for COX-1/COX-2 was determined | ChEMBL. | No reference |
Ratio (binding) | = 4300 | Selectivity for COX-1/COX-2 was determined | ChEMBL. | No reference |
Recovery (ADMET) | > 95 % | Percentage recovery of the compound after 3h incubation with rat hapatocytes was determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.