TDR Targets

Basic information

Technical information

TDR Targets ID: 268919
Name: 6-[2-[[2-(dimethylamino)phenyl]methylsulfinyl ]imidazol-1-yl]pyridin-3-amine
MW: 341.431 | Formula: C17H19N5OS
H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc(nc1)n1ccnc1[S+](Cc1ccccc1N(C)C)[O-]
InChi: 1S/C17H19N5OS/c1-21(2)15-6-4-3-5-13(15)12-24(23)17-19-9-10-22(17)16-8-7-14(18)11-20-16/h3-11H,12,18H2,1-2H3
InChiKey: UYUVDDBKHOYPAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[2-[[2-(dimethylamino)phenyl]methylsulfinyl]-1-imidazolyl]-3-pyridinamine
[2-[[1-(5-amino-2-pyridyl)imidazol-2-yl]sulfinylmethyl]phenyl]-dimethyl-amine
6-[2-[(2-dimethylaminophenyl)methylsulfinyl]imidazol-1-yl]pyridin-3-amine
6-[2-[(2-dimethylaminophenyl)methylsulfinyl]-1-imidazolyl]-3-pyridinamine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Potassium-transporting ATPase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	hypothetical protein	Potassium-transporting ATPase	290 aa	301 aa	25.9 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	306 aa	26.1 %
Echinococcus granulosus	nervana 2	Potassium-transporting ATPase	290 aa	280 aa	29.3 %
Echinococcus multilocularis	nervana 2	Potassium-transporting ATPase	290 aa	280 aa	29.6 %
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	27.3 %
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	27.3 %
Echinococcus multilocularis	nervana 2	Potassium-transporting ATPase	290 aa	265 aa	22.3 %
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta, putative	Potassium-transporting ATPase	290 aa	256 aa	25.4 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	267 aa	21.3 %
Drosophila melanogaster	nervana 1	Potassium-transporting ATPase	290 aa	305 aa	23.9 %
Schistosoma japonicum	ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative	Potassium-transporting ATPase	290 aa	258 aa	23.6 %
Onchocerca volvulus	Glutamate carboxypeptidase 2 homolog	Potassium-transporting ATPase	290 aa	301 aa	25.9 %
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	254 aa	23.6 %
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	266 aa	25.6 %
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Potassium-transporting ATPase	290 aa	258 aa	24.4 %
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Potassium-transporting ATPase	290 aa	266 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Toxoplasma gondii	P-type ATPase4, putative	0.0017	0.0366	1
Schistosoma mansoni	thyroid hormone receptor	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0017	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0213	1	1
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0012	0.0097	0.0097
Onchocerca volvulus	Protein ultraspiracle homolog	0.0213	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0213	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0101	0.4468	0.4356
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0113	0.506	0.496
Schistosoma mansoni	zinc finger protein	0.0101	0.4468	0.4356
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0101	0.4468	0.4468
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Brugia malayi	tailless protein	0.0101	0.4468	0.4468
Loa Loa (eye worm)	hypothetical protein	0.0113	0.506	0.506
Schistosoma mansoni	transmemberane protein	0.0026	0.0788	0.0602
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0213	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0213	1	1
Brugia malayi	hypothetical protein	0.0101	0.4468	0.4468
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0213	1	1
Echinococcus multilocularis	nervana 2	0.0026	0.0788	0.0602
Brugia malayi	Membrane calcium atpase protein 3	0.0014	0.0198	0.0198
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.0366	1
Brugia malayi	nuclear receptor RXR	0.0101	0.4468	0.4468
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0213	1	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0113	0.506	0.496
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0017	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.506	0.506
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0017	0.0366	0.0171
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0213	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0213	1	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0101	0.4468	0.4468
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0213	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0113	0.506	0.496
Brugia malayi	nuclear receptor RXR	0.0113	0.506	0.506
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0026	0.0788	0.0602
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0017	0.0366	1
Brugia malayi	Na,K-ATPase alpha subunit	0.0017	0.0366	0.0366
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0213	1	1
Echinococcus multilocularis	nervana 2	0.0026	0.0788	0.0602
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0017	0.0366	0.0366
Echinococcus granulosus	nervana 2	0.0026	0.0788	0.0602
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0213	1	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.0788	0.0602
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0101	0.4468	0.4356
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0101	0.4468	0.4356
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0026	0.0788	0.0602
Schistosoma mansoni	thyroid hormone receptor	0.0213	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0788	0.0788
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0017	0.0366	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.0788	0.0602
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0012	0.0097	0.5
Brugia malayi	nuclear receptor NHR-88	0.0213	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0213	1	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.0366	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0101	0.4468	0.4258
Brugia malayi	Nuclear hormone receptor-like 1	0.0213	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0213	1	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.0788	0.0602
Echinococcus multilocularis	nervana 2	0.0026	0.0788	0.0602
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0213	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0101	0.4468	0.4356
Schistosoma mansoni	nuclear receptor nhr-48	0.0101	0.4468	0.4356
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0113	0.506	0.496
Schistosoma mansoni	ATPase	0.0017	0.0366	0.0171
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0017	0.0366	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.506	0.506
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Onchocerca volvulus		0.0101	0.4468	0.4258
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0213	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0113	0.506	0.506
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0017	0.0366	1
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0014	0.0198	0.4509
Brugia malayi	nuclear receptor NHR-88	0.0101	0.4468	0.4468
Schistosoma mansoni	coup transcription factor	0.0213	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0213	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0213	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0101	0.4468	0.4468
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0101	0.4468	0.4356
Schistosoma mansoni	nuclear hormone receptor	0.0213	1	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.0788	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0014	0.0198	0.4509
Echinococcus multilocularis	ecdysone induced protein 78C	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0366	0.0366
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0101	0.4468	0.4356
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0014	0.0198	0.4509
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0017	0.0366	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0788	0.0788
Brugia malayi	nuclear hormone receptor family member odr-7	0.0101	0.4468	0.4468
Brugia malayi	photoreceptor-specific nuclear receptor	0.0213	1	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0101	0.4468	0.4356
Leishmania major	calcium motive p-type ATPase, putative	0.0014	0.0198	0.4509
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0014	0.0198	0.4509
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Schistosoma mansoni	nuclear hormone receptor	0.0101	0.4468	0.4356
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0101	0.4468	0.4468
Onchocerca volvulus		0.0213	1	1
Loa Loa (eye worm)	DR-78	0.0101	0.4468	0.4468
Brugia malayi	Nuclear hormone receptor E75	0.0101	0.4468	0.4468
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.506	0.506
Echinococcus multilocularis	FTZ F1 alpha	0.0213	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0101	0.4468	0.4356
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0012	0.0097	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0213	1	1
Onchocerca volvulus		0.0101	0.4468	0.4258
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0213	1	1
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0017	0.0366	1
Brugia malayi	ecdysone receptor	0.0101	0.4468	0.4468
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0017	0.0366	0.0171
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0017	0.0366	0.0171
Echinococcus granulosus	nervana 2	0.0026	0.0788	0.0602
Schistosoma mansoni	retinoic acid receptor RXR	0.0213	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0101	0.4468	0.4356
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0017	0.0366	1
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0017	0.0366	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0026	0.0788	0.0602
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0017	0.0366	0.0171
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Brugia malayi	hypothetical protein	0.0113	0.506	0.506
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0017	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.506	0.506
Brugia malayi	nuclear hormone receptor	0.0101	0.4468	0.4468
Brugia malayi	Nuclear hormone receptor-like 1	0.0113	0.506	0.506
Brugia malayi	nuclear receptor NHR-67	0.0101	0.4468	0.4468
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0113	0.506	0.506
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0213	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0213	1	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.0788	0.0602
Leishmania major	calcium-translocating P-type ATPase	0.0017	0.0366	1
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0026	0.0788	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0213	1	1
Leishmania major	calcium-transporting ATPase, putative	0.0014	0.0198	0.4509
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0014	0.0198	0.0198
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0213	1	1
Plasmodium vivax	P-type ATPase4, putative	0.0017	0.0366	0.5
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0213	1	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0101	0.4468	0.4468
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0213	1	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0213	1	1
Schistosoma mansoni	nuclear receptor	0.0101	0.4468	0.4356
Schistosoma mansoni	ATPase	0.0017	0.0366	0.0171
Echinococcus granulosus	nervana 2	0.0026	0.0788	0.0602
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0017	0.0366	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0213	1	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1
Brugia malayi	conserved hypotetical protein	0.0101	0.4468	0.4468
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.0788	0.0602
Loa Loa (eye worm)	steroid hormone receptor	0.0213	1	1
Plasmodium vivax	calcium-transporting ATPase, putative	0.0017	0.0366	0.5
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0213	1	1
Brugia malayi	nuclear hormone receptor	0.0213	1	1
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0017	0.0366	0.0171
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0014	0.0198	0.4509
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0026	0.0788	0.0602
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0017	0.0366	1
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0014	0.0198	0.4509
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0017	0.0366	0.0171
Echinococcus multilocularis	nervana 2	0.0026	0.0788	0.0602
Leishmania major	P-type ATPase, putative	0.0014	0.0198	0.4509
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0012	0.0097	0.0097
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0213	1	1
Schistosoma mansoni	nuclear receptor	0.0101	0.4468	0.4356
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0017	0.0366	1
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0026	0.0788	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0017	0.0366	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0213	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0101	0.4468	0.4468
Echinococcus granulosus	nuclear receptor nhr 48	0.0101	0.4468	0.4356
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0366	0.0366
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0213	1	1
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0017	0.0366	1
Onchocerca volvulus		0.0026	0.0788	0.0439
Brugia malayi	hypothetical protein	0.0113	0.506	0.506
Brugia malayi	hypothetical protein	0.0101	0.4468	0.4468
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0101	0.4468	0.4356
Loa Loa (eye worm)	E1-E2 ATPase	0.0011	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1
Brugia malayi	Steroid receptor seven-up type 2	0.0213	1	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0101	0.4468	0.4356
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0213	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0101	0.4468	0.4258
Echinococcus granulosus	thyroid hormone receptor alpha	0.0101	0.4468	0.4356
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0017	0.0366	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0213	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0213	1	1
Onchocerca volvulus		0.0026	0.0788	0.0439
Schistosoma mansoni	nuclear hormone receptor	0.0101	0.4468	0.4356
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0017	0.0366	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0213	1	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0101	0.4468	0.4468
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0213	1	1
Brugia malayi	steroid hormone receptor	0.0213	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Echinococcus granulosus	nervana 2	0.0026	0.0788	0.0602
Onchocerca volvulus	Bile acid receptor homolog	0.0213	1	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.4468	0.4468
Echinococcus multilocularis	nuclear receptor nhr 48	0.0101	0.4468	0.4356
Brugia malayi	E1-E2 ATPase family protein	0.0011	0.0061	0.0061
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0017	0.0366	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.7 uM	In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles	ChEMBL.	8558532
IC50 (binding)	= 5.7 uM	In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesicles	ChEMBL.	8558532
Inhibition (functional)	= 48 %	Gastric antisecretory activity was tested in rats at 30 mg/kg, po expressed as the percentage of inhibition against the acid output of the control group	ChEMBL.	8558532
Inhibition (functional)	= 48 %	Gastric antisecretory activity was tested in rats at 30 mg/kg, po expressed as the percentage of inhibition against the acid output of the control group	ChEMBL.	8558532

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 10545194

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 268919