Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0289 | 0.0632 | 0.0599 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0289 | 0.0632 | 0.0599 |
Loa Loa (eye worm) | thymidylate synthase | 0.3824 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0289 | 0.0632 | 1 |
Onchocerca volvulus | 0.0064 | 0.0034 | 0.0034 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3824 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3824 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3824 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3824 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.3824 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1819 | 0.4687 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.3824 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3824 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1819 | 0.4687 | 0.4668 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3824 | 1 | 1 |
Onchocerca volvulus | 0.3824 | 1 | 1 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3824 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.3824 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3824 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3824 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MAC (functional) | = 100 ug ml-1 | In vitro antischistosomal activity, minimum active concentration to cause severe damage or death of worms at 96 h against Schistosoma mansoni | ChEMBL. | 7241518 |
MAC (functional) | = 100 ug ml-1 | In vitro antischistosomal activity, minimum active concentration to cause severe damage or death of worms at 96 h against Schistosoma mansoni | ChEMBL. | 7241518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.