Detailed information for compound 269152

Basic information

Technical information
  • TDR Targets ID: 269152
  • Name: 6-phenyl-3-propyl-[1,2,4]triazolo[3,4-f]pyrid azine
  • MW: 238.288 | Formula: C14H14N4
  • H donors: 0 H acceptors: 3 LogP: 2.59 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nnc2n1nc(cc2)c1ccccc1
  • InChi: 1S/C14H14N4/c1-2-6-13-15-16-14-10-9-12(17-18(13)14)11-7-4-3-5-8-11/h3-5,7-10H,2,6H2,1H3
  • InChiKey: JEFXLDJWDPFUSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0079 0.1558 0.2044
Echinococcus granulosus ecdysone induced protein 78C 0.0167 0.3462 0.3439
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0526 0.0557
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0079 0.1558 0.2044
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0698 0.0665
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0204 0.0169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0167 0.3462 0.3897
Loa Loa (eye worm) nuclear hormone receptor 0.0079 0.1558 0.2044
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0088 0.1762 0.1732
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1929 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0526 0.0557
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0076 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0167 0.3462 0.6497
Brugia malayi nuclear hormone receptor 0.0167 0.3462 0.4602
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0079 0.1558 0.1528
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0038 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1326 0.1733
Echinococcus multilocularis thyroid hormone receptor alpha 0.0167 0.3462 0.3439
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0088 0.1762 0.2318
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1929 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0167 0.3462 0.3439
Echinococcus granulosus thyroid hormone receptor alpha 0.0079 0.1558 0.1528
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0203 0.0168
Schistosoma mansoni inositol monophosphatase 0.0038 0.0667 0.0718
Echinococcus multilocularis solute carrier family 5 0.0039 0.0698 0.0665
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Loa Loa (eye worm) histone methyltransferase 0.001 0.0076 0.0054
Echinococcus multilocularis cpg binding protein 0.0031 0.0523 0.0489
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1929 0.2543
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1326 0.1733
Brugia malayi nuclear receptor RXR 0.0079 0.1558 0.2044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0204 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0167 0.3462 0.3439
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0583 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0605 0.0764
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0951 0.1229
Echinococcus multilocularis neuropeptide s receptor 0.0471 1 1
Onchocerca volvulus 0.0031 0.0526 0.0084
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0088 0.1762 0.1732
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0167 0.3462 0.4602
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1326 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0167 0.3462 0.4602
Schistosoma mansoni high-affinity choline transporter 0.0354 0.7481 0.8468
Echinococcus multilocularis nuclear receptor nhr 48 0.0079 0.1558 0.1528
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0167 0.3462 0.3439
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0667 0.5323
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0667 0.2687
Brugia malayi nuclear receptor NHR-88 0.0167 0.3462 0.4602
Echinococcus granulosus dnaJ subfamily B 0.0416 0.8829 0.8824
Echinococcus granulosus Nuclear hormone receptor HR96 0.0079 0.1558 0.1528
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1326 0.1733
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0167 0.3462 0.3897
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0951 0.1229
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.4436 0.591
Echinococcus granulosus tar DNA binding protein 0.0068 0.1326 0.1295
Echinococcus multilocularis GPCR, family 2 0.0016 0.0203 0.0168
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1929 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1929 1
Brugia malayi MH2 domain containing protein 0.0121 0.2476 0.3277
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Onchocerca volvulus 0.0079 0.1558 0.2338
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0488 0.0454
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0167 0.3462 0.3439
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0204 0.0191
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0167 0.3462 0.3897
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0167 0.3462 0.3439
Loa Loa (eye worm) hypothetical protein 0.0088 0.1762 0.2318
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0698 0.0665
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1929 0.3149
Schistosoma mansoni inositol monophosphatase 0.0038 0.0667 0.0718
Brugia malayi Nuclear hormone receptor-like 1 0.0167 0.3462 0.4602
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Loa Loa (eye worm) hypothetical protein 0.0088 0.1762 0.2318
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0204 0.0226
Loa Loa (eye worm) hypothetical protein 0.0088 0.1762 0.2318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0167 0.3462 0.4602
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0204 0.0169
Brugia malayi photoreceptor-specific nuclear receptor 0.0167 0.3462 0.4602
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0167 0.3462 0.4602
Brugia malayi orphan nuclear receptor NR2E1 0.0079 0.1558 0.2044
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0204 0.0226
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.1558 0.1528
Echinococcus granulosus Nuclear hormone receptor HR96 0.0079 0.1558 0.1528
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1326 0.1295
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0079 0.1558 0.1528
Schistosoma mansoni nuclear hormone receptor 0.0079 0.1558 0.1731
Echinococcus multilocularis neuropeptide receptor A26 0.0471 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0079 0.1558 0.1528
Brugia malayi conserved hypotetical protein 0.0079 0.1558 0.2044
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2476 0.3277
Giardia lamblia Kinase, PLK 0.0096 0.1929 0.5
Schistosoma mansoni cpg binding protein 0.0029 0.0487 0.0513
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0167 0.3462 0.3897
Brugia malayi ecdysteroid receptor 0.0167 0.3462 0.4602
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0526 0.0492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0167 0.3462 0.4602
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0698 0.5676
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.8829 0.8824
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0667 0.2687
Brugia malayi hypothetical protein 0.0125 0.2544 0.3369
Echinococcus granulosus GPCR family 2 0.0016 0.0203 0.0168
Echinococcus multilocularis ecdysone induced protein 78C 0.0167 0.3462 0.3439
Brugia malayi hypothetical protein 0.0088 0.1762 0.2318
Brugia malayi steroid hormone receptor 0.0167 0.3462 0.4602
Loa Loa (eye worm) hypothetical protein 0.0031 0.0526 0.0658
Brugia malayi Nuclear hormone receptor E75 0.0079 0.1558 0.2044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0167 0.3462 0.4602
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0079 0.1558 0.2044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0167 0.3462 0.4602
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0204 0.0169
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0526 0.0492
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0038 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1929 0.3808
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0167 0.3462 0.3897
Echinococcus granulosus solute carrier family 5 0.0039 0.0698 0.0665
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0526 0.0557
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1217 0.1344
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0526 0.0557
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0079 0.1558 0.2338
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0167 0.3462 0.3439
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1929 0.3808
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Echinococcus multilocularis high affinity choline transporter 1 0.0354 0.7481 0.7472
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0204 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0167 0.3462 0.4602
Schistosoma mansoni nuclear hormone receptor 0.0167 0.3462 0.3897
Loa Loa (eye worm) nuclear receptor NHR-67 0.0079 0.1558 0.2044
Loa Loa (eye worm) DR-78 0.0079 0.1558 0.2044
Schistosoma mansoni hypothetical protein 0.0016 0.0203 0.0191
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0883 0.1743
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Brugia malayi Pre-SET motif family protein 0.0212 0.4436 0.591
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1929 0.3808
Brugia malayi nuclear hormone receptor 0.0079 0.1558 0.2044
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0079 0.1558 0.2338
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0605 0.0764
Onchocerca volvulus Huntingtin homolog 0.0125 0.2544 0.4492
Schistosoma mansoni hypothetical protein 0.0016 0.0203 0.0191
Schistosoma mansoni nuclear receptor 0.0079 0.1558 0.1731
Onchocerca volvulus 0.0039 0.0698 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0167 0.3462 0.4602
Schistosoma mansoni hypothetical protein 0.0016 0.0203 0.0191
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Schistosoma mansoni cpg binding protein 0.0031 0.0523 0.0554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0167 0.3462 0.3439
Loa Loa (eye worm) hypothetical protein 0.0088 0.1762 0.2318
Schistosoma mansoni inositol transporter 0.0039 0.0698 0.0753
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0698 0.0665
Schistosoma mansoni steroid hormone receptor ad4bp 0.0167 0.3462 0.3897
Schistosoma mansoni nuclear receptor nhr-48 0.0079 0.1558 0.1731
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0167 0.3462 0.3439
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0526 0.0492
Brugia malayi hypothetical protein 0.0079 0.1558 0.2044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0167 0.3462 0.4602
Brugia malayi GH02984p 0.0354 0.7481 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0167 0.3462 0.6497
Schistosoma mansoni inositol transporter 0.0039 0.0698 0.0753
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1929 0.2543
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0667 0.1317
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0204 0.5
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Loa Loa (eye worm) hypothetical protein 0.0125 0.2544 0.3369
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0038 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1326 0.1467
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 0.1762 0.1963
Brugia malayi nuclear receptor NHR-67 0.0079 0.1558 0.2044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0667 0.1317
Schistosoma mansoni sodium/solute symporter 0.0039 0.0698 0.0753
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0167 0.3462 0.4602
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0079 0.1558 0.1528
Brugia malayi nuclear hormone receptor family member nhr-6 0.0079 0.1558 0.2044
Schistosoma mansoni hypothetical protein 0.0035 0.0605 0.0647
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0667 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0079 0.1558 0.1731
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Schistosoma mansoni thyroid hormone receptor 0.0167 0.3462 0.3897
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0203 0.0225
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1929 0.19
Schistosoma mansoni coup transcription factor 0.0167 0.3462 0.3897
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0667 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.1762 0.2318
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0667 0.0634
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0167 0.3462 0.3439
Brugia malayi nuclear receptor RXR 0.0088 0.1762 0.2318
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0667 0.0634
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1929 0.2153
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1326 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0167 0.3462 0.4602
Onchocerca volvulus 0.0167 0.3462 0.6497
Brugia malayi Pre-SET motif family protein 0.0031 0.0526 0.0658
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0698 0.0665
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0167 0.3462 0.4602
Brugia malayi ecdysone receptor 0.0079 0.1558 0.2044
Schistosoma mansoni nuclear hormone receptor 0.0079 0.1558 0.1731
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0203 0.0225
Brugia malayi CXXC zinc finger family protein 0.0029 0.0487 0.0606
Echinococcus granulosus cpg binding protein 0.0031 0.0523 0.0489
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0167 0.3462 0.3439
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1326 0.1467
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1326 0.1467
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0698 0.0665
Schistosoma mansoni hypothetical protein 0.0416 0.8829 1
Brugia malayi Steroid receptor seven-up type 2 0.0167 0.3462 0.4602
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0079 0.1558 0.1528
Trichomonas vaginalis set domain proteins, putative 0.0242 0.5067 1
Brugia malayi TAR-binding protein 0.0068 0.1326 0.1733
Schistosoma mansoni retinoic acid receptor RXR 0.0167 0.3462 0.3897
Schistosoma mansoni kinase 0.0049 0.091 0.0995
Brugia malayi hypothetical protein 0.0088 0.1762 0.2318
Onchocerca volvulus 0.0079 0.1558 0.2338
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0487 0.0606
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0203 0.0168
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0167 0.3462 0.3439
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0203 0.0225
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0079 0.1558 0.1731
Schistosoma mansoni RAR-like nuclear receptor 0.0167 0.3462 0.3897
Schistosoma mansoni zinc finger protein 0.0079 0.1558 0.1731
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0583 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0038 0.0002
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1929 0.3808
Loa Loa (eye worm) steroid hormone receptor 0.0167 0.3462 0.4602
Plasmodium vivax SET domain protein, putative 0.0031 0.0526 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0667 0.2687
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1929 0.3808
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0167 0.3462 0.4602
Onchocerca volvulus Bile acid receptor homolog 0.0167 0.3462 0.6497
Brugia malayi Inositol-1 0.0038 0.0667 0.0848
Schistosoma mansoni thyroid hormone receptor 0.0167 0.3462 0.3897
Loa Loa (eye worm) hypothetical protein 0.0354 0.7481 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0167 0.3462 0.3439
Brugia malayi isocitrate dehydrogenase 0.0016 0.0204 0.0226
Loa Loa (eye worm) hypothetical protein 0.0016 0.0203 0.0225
Loa Loa (eye worm) hypothetical protein 0.0051 0.0951 0.1229
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2476 0.3277
Echinococcus granulosus high affinity choline transporter 1 0.0354 0.7481 0.7472
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0079 0.1558 0.1528
Schistosoma mansoni nuclear receptor 0.0079 0.1558 0.1731
Brugia malayi nuclear hormone receptor family member odr-7 0.0079 0.1558 0.2044
Brugia malayi RNA binding protein 0.0068 0.1326 0.1733
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0204 0.0169
Brugia malayi tailless protein 0.0079 0.1558 0.2044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0076 0.0041
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1929 0.3808
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0698 0.0665
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.1762 0.2318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0698 0.089
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1929 0.3808
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0203 0.0168
Onchocerca volvulus Huntingtin homolog 0.0125 0.2544 0.4492
Trypanosoma brucei polo-like protein kinase 0.0096 0.1929 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0526 0.3697
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0088 0.1762 0.1963
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0167 0.3462 0.4602
Schistosoma mansoni hypothetical protein 0.0016 0.0203 0.0191
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0167 0.3462 0.3897
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Brugia malayi Nuclear hormone receptor E75 0.0079 0.1558 0.2044
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0883 0.1743
Loa Loa (eye worm) hypothetical protein 0.0125 0.2544 0.3369
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0698 0.089
Echinococcus granulosus neuropeptide receptor A26 0.0471 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0167 0.3462 0.4602
Loa Loa (eye worm) hypothetical protein 0.0167 0.3462 0.4602
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0167 0.3462 0.4602
Loa Loa (eye worm) RNA binding protein 0.0068 0.1326 0.1733
Brugia malayi nuclear receptor NHR-88 0.0079 0.1558 0.2044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0951 0.1229
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0167 0.3462 0.4602
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0667 0.1317
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0167 0.3462 0.3439
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0667 0.2687
Echinococcus granulosus FTZ F1 alpha 0.0167 0.3462 0.3439
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0698 0.0665
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.1558 0.1528
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0203 0.0168
Schistosoma mansoni cpg binding protein 0.0031 0.0523 0.0554
Loa Loa (eye worm) inositol-1 0.0038 0.0667 0.0848
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1075 1
Onchocerca volvulus 0.0242 0.5067 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1558 0.2044
Echinococcus multilocularis FTZ F1 alpha 0.0167 0.3462 0.3439
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0074 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.1762 0.2318
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1929 0.19
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0038 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0167 0.3462 0.4602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0167 0.3462 0.4602

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) 0 nM in vitro inhibition of [3H]-diazepam binding against rat Benzodiazepine receptor ChEMBL. 6113284
Inhibition (binding) = 38 % In vitro inhibition of [3H]-diazepam binding towards Benzodiazepine receptor at 1 microM ChEMBL. 6113284
Inhibition (binding) = 38 % In vitro inhibition of [3H]-diazepam binding towards Benzodiazepine receptor at 1 microM ChEMBL. 6113284
MABP (functional) = 110 Hypotensive activity in saline-loaded spontaneously hypertensive rats following 100 mg/kg p.o. administration. ChEMBL. 6113284
MABP (functional) = 145 Hypotensive activity evaluated as mean arterial blood pressure (MABP) in saline-loaded spontaneously hypertensive rats dosed (per oral) at 25 mg/kg ChEMBL. 6113284

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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