TDR Targets

Basic information

Technical information

TDR Targets ID: 269153
Name: 6-phenyl-3-(trifluoromethyl)-[1,2,4]triazolo[ 3,4-f]pyridazine
MW: 264.206 | Formula: C12H7F3N4
H donors: 0 H acceptors: 3 LogP: 2.32 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: FC(c1nnc2n1nc(cc2)c1ccccc1)(F)F
InChi: 1S/C12H7F3N4/c13-12(14,15)11-17-16-10-7-6-9(18-19(10)11)8-4-2-1-3-5-8/h1-7H
InChiKey: WCZVDXSSHBCXPA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0062	0.0854	0.1395
Loa Loa (eye worm)	DR-78	0.0029	0.0091	0.0148
Leishmania major	cytochrome p450-like protein	0.0044	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0132	0.2459	0.2458
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0062	0.0854	0.1394
Brugia malayi	nuclear hormone receptor	0.0029	0.0091	0.0148
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0062	0.0854	0.1395
Brugia malayi	steroid hormone receptor	0.0062	0.0854	0.1394
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0062	0.0854	0.1394
Echinococcus multilocularis	ecdysone induced protein 78C	0.0062	0.0854	0.1395
Schistosoma mansoni	hypothetical protein	0.0026	0	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0033	0.0173	0.0282
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0173	0.0282
Brugia malayi	nuclear receptor RXR	0.0033	0.0173	0.0282
Brugia malayi	hypothetical protein	0.0029	0.0091	0.0148
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0275	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0153	0.025
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Brugia malayi	Cytochrome P450 family protein	0.0044	0.0417	0.0681
Echinococcus granulosus	thymidylate synthase	0.0277	0.5819	0.9501
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0029	0.0091	0.0149
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0033	0.0173	0.0282
Brugia malayi	hypothetical protein	0.0029	0.0091	0.0148
Schistosoma mansoni	RAR-like nuclear receptor	0.0062	0.0854	0.1395
Brugia malayi	nuclear receptor NHR-67	0.0029	0.0091	0.0148
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0062	0.0854	0.1395
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0275	0.0449
Loa Loa (eye worm)	cytochrome P450 family protein	0.0044	0.0417	0.0681
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0062	0.0854	0.1395
Echinococcus multilocularis	thymidylate synthase	0.0277	0.5819	0.9501
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0458	1	0.5
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0275	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0275	0.0448
Trypanosoma cruzi	cytochrome P450, putative	0.0044	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0282
Brugia malayi	hypothetical protein	0.0033	0.0173	0.0282
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0275	0.0274
Trypanosoma brucei	cytochrome P450, putative	0.0044	0.0417	0.0417
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0062	0.0854	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0062	0.0854	0.1332
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0029	0.0076	0.0123
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0062	0.0854	0.1395
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0062	0.0854	0.1394
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0062	0.0854	0.1395
Brugia malayi	Dihydrofolate reductase	0.0291	0.6124	1
Brugia malayi	Nuclear hormone receptor E75	0.0029	0.0091	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0282
Brugia malayi	nuclear receptor RXR	0.0029	0.0091	0.0148
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0291	0.6124	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0029	0.0091	0.0149
Trichomonas vaginalis	conserved hypothetical protein	0.0132	0.2459	1
Brugia malayi	dihydrofolate reductase family protein	0.0291	0.6124	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0029	0.0091	0.0149
Loa Loa (eye worm)	CYP4Cod1	0.0044	0.0417	0.0681
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0029	0.0091	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Brugia malayi	hypothetical protein	0.0132	0.2459	0.4014
Echinococcus granulosus	thyroid hormone receptor alpha	0.0029	0.0091	0.0149
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0277	0.5819	0.9501
Brugia malayi	nuclear receptor NHR-88	0.0029	0.0091	0.0148
Echinococcus multilocularis	FTZ F1 alpha	0.0062	0.0854	0.1395
Brugia malayi	conserved hypotetical protein	0.0029	0.0091	0.0148
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0029	0.0091	0.0149
Echinococcus multilocularis	roundabout 2	0.0032	0.0153	0.025
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0029	0.0091	0.0149
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0062	0.0854	0.1394
Schistosoma mansoni	nuclear hormone receptor	0.0062	0.0854	0.1395
Loa Loa (eye worm)	cytochrome P450 family protein	0.0044	0.0417	0.0681
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0275	0.0449
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0275	0.0449
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0275	0.0449
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0173	0.0282
Brugia malayi	Cytochrome P450 family protein	0.0065	0.0908	0.1482
Brugia malayi	Steroid receptor seven-up type 2	0.0062	0.0854	0.1394
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0062	0.0854	0.1394
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0062	0.0854	0.1394
Loa Loa (eye worm)	steroid hormone receptor	0.0062	0.0854	0.1394
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0275	0.0449
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0062	0.0854	0.1394
Trypanosoma cruzi	cytochrome P450, putative	0.0044	0.0417	0.0417
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0027	0.0033	0.0054
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0062	0.0854	0.1395
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0458	1	1
Onchocerca volvulus		0.0277	0.5819	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0091	0.0149
Schistosoma mansoni	dihydrofolate reductase	0.0291	0.6124	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0062	0.0854	0.1395
Onchocerca volvulus		0.0062	0.0854	0.1332
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0275	0.0449
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0062	0.0854	0.1395
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0458	1	0.5
Schistosoma mansoni	nuclear receptor	0.0029	0.0091	0.0149
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0275	0.0274
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0029	0.0091	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0062	0.0854	0.1395
Brugia malayi	Nuclear hormone receptor E75	0.0029	0.0091	0.0148
Brugia malayi	photoreceptor-specific nuclear receptor	0.0062	0.0854	0.1394
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.0701	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Loa Loa (eye worm)	thymidylate synthase	0.0277	0.5819	0.9501
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.0091	0.0149
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0029	0.0091	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0062	0.0854	0.1395
Brugia malayi	ecdysone receptor	0.0029	0.0091	0.0148
Brugia malayi	Nuclear hormone receptor-like 1	0.0062	0.0854	0.1394
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0291	0.6124	1
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0458	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0062	0.0854	0.1395
Schistosoma mansoni	coup transcription factor	0.0062	0.0854	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0062	0.0854	0.1395
Onchocerca volvulus	Bile acid receptor homolog	0.0062	0.0854	0.1332
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0062	0.0854	0.1395
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0062	0.0854	0.1394
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0062	0.0854	0.1394
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0173	0.0282
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0029	0.0091	0.0148
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0029	0.0091	0.0148
Schistosoma mansoni	thyroid hormone receptor	0.0062	0.0854	0.1395
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0029	0.0091	0.0148
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0029	0.0076	0.0123
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0091	0.0149
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0275	0.0449
Loa Loa (eye worm)	cytochrome P450 family protein	0.0065	0.0908	0.1482
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0062	0.0854	0.1395
Echinococcus multilocularis	dihydrofolate reductase	0.0291	0.6124	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0062	0.0854	0.1394
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0029	0.0091	0.0149
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0062	0.0854	0.1394
Brugia malayi	Cytochrome P450 family protein	0.0044	0.0417	0.0681
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0029	0.0091	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0062	0.0854	0.1394
Brugia malayi	hypothetical protein	0.0033	0.0173	0.0282
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0033	0.0173	0.0282
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.0701	0.1145
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0275	0.0274
Brugia malayi	orphan nuclear receptor NR2E1	0.0029	0.0091	0.0148
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0062	0.0854	0.1394
Brugia malayi	tailless protein	0.0029	0.0091	0.0148
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0029	0.0091	0.0149
Echinococcus granulosus	ecdysone induced protein 78C	0.0062	0.0854	0.1395
Schistosoma mansoni	lipoxygenase	0.0056	0.0701	0.1145
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0062	0.0854	0.1394
Schistosoma mansoni	nuclear receptor	0.0029	0.0091	0.0149
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0062	0.0854	0.1395
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0062	0.0854	0.1394
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0062	0.0854	0.1394
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0062	0.0854	0.1395
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0033	0.0173	0.0282
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0275	0.0448
Brugia malayi	nuclear hormone receptor family member odr-7	0.0029	0.0091	0.0148
Schistosoma mansoni	cell adhesion molecule	0.0027	0.0033	0.0054
Onchocerca volvulus	Protein ultraspiracle homolog	0.0062	0.0854	0.1332
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0062	0.0854	0.1394
Echinococcus granulosus	roundabout 2	0.0032	0.0153	0.025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0033	0.0053
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0458	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0277	0.5819	0.9501
Chlamydia trachomatis	dihydrofolate reductase	0.0291	0.6124	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0062	0.0854	0.1395
Brugia malayi	ecdysteroid receptor	0.0062	0.0854	0.1394
Brugia malayi	nuclear hormone receptor	0.0062	0.0854	0.1394
Mycobacterium ulcerans	thymidylate synthase	0.0277	0.5819	0.9501
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.0091	0.0149
Schistosoma mansoni	cytochrome P450	0.0026	0	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0282
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0062	0.0854	0.1394
Loa Loa (eye worm)	nuclear hormone receptor	0.0029	0.0091	0.0148
Echinococcus granulosus	dihydrofolate reductase	0.0291	0.6124	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Schistosoma mansoni	retinoic acid receptor RXR	0.0062	0.0854	0.1395
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0062	0.0854	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0153	0.025
Echinococcus granulosus	cytochrome P450 2K1	0.0026	0	0.0001
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0275	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0062	0.0854	0.1395
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0029	0.0091	0.0149
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0062	0.0854	0.1395
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0277	0.5819	0.9501
Mycobacterium tuberculosis	Hypothetical protein	0.0132	0.2459	0.4014
Schistosoma mansoni	zinc finger protein	0.0029	0.0091	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0854	0.1394
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0291	0.6124	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0062	0.0854	0.1395
Echinococcus multilocularis		0.0026	0	0.0001
Echinococcus granulosus	FTZ F1 alpha	0.0062	0.0854	0.1395
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0062	0.0854	0.1394
Echinococcus multilocularis	nuclear receptor nhr 48	0.0029	0.0091	0.0149
Loa Loa (eye worm)	dihydrofolate reductase	0.0291	0.6124	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0091	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0282
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0044	0.0417	0.0681
Brugia malayi	thymidylate synthase	0.0277	0.5819	0.9501
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0275	0.0274
Brugia malayi	nuclear receptor NHR-88	0.0062	0.0854	0.1394

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Binding affinity to human recombinant biotinylated BRD9 by UV spectrophotometric analysis	ChEMBL.	No reference
Activity (binding)	= 212 uL	Binding affinity to human recombinant biotinylated BRD9 assessed as retention volume at 4 uM by FAC-MS analysis	ChEMBL.	No reference
Delta Tm (binding)	= -0.6 degrees C	Binding affinity to human recombinant biotinylated BRD9 assessed as change in melting temperature at 4 uM by thermal shift assay	ChEMBL.	No reference
ED50 (functional)	= 15 mg kg-1	Anxiolytic activity for protection against pentylenetetrazole-induced convulsions in experiment 1	ChEMBL.	6113284
ED50 (functional)	= 18 mg kg-1	Anxiolytic activity for protection against pentylenetetrazole-induced convulsions in experiment 2	ChEMBL.	6113284
IC50 (binding)	nM	in vitro inhibition of [3H]-diazepam binding against rat Benzodiazepine receptor	ChEMBL.	6113284
IC50 (binding)	0 nM	in vitro inhibition of [3H]-diazepam binding against rat Benzodiazepine receptor	ChEMBL.	6113284
Inhibition (binding)	%	In vitro inhibition of [3H]-diazepam binding towards Benzodiazepine receptor at 1 uM; Not tested.	ChEMBL.	6113284
Inhibition (binding)	0 %	In vitro inhibition of [3H]-diazepam binding towards Benzodiazepine receptor at 1 uM; Not tested.	ChEMBL.	6113284

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL156241
PubChem: 12726857

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 269153