Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0213 | 0.9504 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0101 | 0.3503 | 0.3686 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.1409 | 0.1483 |
Brugia malayi | nuclear receptor RXR | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4146 | 0.4362 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0213 | 0.9504 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0213 | 0.9504 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0213 | 0.9504 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | DR-78 | 0.0101 | 0.3503 | 0.3686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 0.1483 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0101 | 0.3503 | 0.3686 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0101 | 0.3503 | 0.3686 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0213 | 0.9504 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0502 | 0.0528 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0101 | 0.3503 | 0.3686 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0048 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0048 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0048 | 0.005 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0048 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0213 | 0.9504 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0113 | 0.4146 | 0.4362 |
Brugia malayi | steroid hormone receptor | 0.0213 | 0.9504 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0048 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0213 | 0.9504 | 1 |
Brugia malayi | hypothetical protein | 0.0113 | 0.4146 | 0.4362 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0048 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5843 | 0.6148 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4146 | 0.4362 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.5843 | 0.6148 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0213 | 0.9504 | 1 |
Brugia malayi | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0213 | 0.9504 | 1 |
Brugia malayi | tailless protein | 0.0101 | 0.3503 | 0.3686 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0213 | 0.9504 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0502 | 0.0528 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0101 | 0.3503 | 0.3686 |
Onchocerca volvulus | 0.0101 | 0.3503 | 0.3686 | |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0101 | 0.3503 | 0.3686 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4146 | 0.4362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 0.1483 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0101 | 0.3503 | 0.3686 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0101 | 0.3503 | 0.3686 |
Schistosoma mansoni | nuclear receptor | 0.0101 | 0.3503 | 0.3686 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0502 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0502 | 0.0528 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0213 | 0.9504 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0213 | 0.9504 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0048 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.1409 | 0.1483 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0048 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4146 | 0.4362 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0213 | 0.9504 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0502 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0213 | 0.9504 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0113 | 0.4146 | 0.4362 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.1409 | 0.1483 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0048 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0048 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.4146 | 0.4362 |
Brugia malayi | ecdysteroid receptor | 0.0213 | 0.9504 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0213 | 0.9504 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0113 | 0.4146 | 0.4362 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0502 | 0.0528 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5843 | 0.6148 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0101 | 0.3503 | 0.3686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 0.1483 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0101 | 0.3503 | 0.3686 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0502 | 0.0528 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0113 | 0.4146 | 0.4362 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.1409 | 0.1483 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0213 | 0.9504 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 0.1483 |
Brugia malayi | nuclear hormone receptor | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0213 | 0.9504 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0213 | 0.9504 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.1409 | 0.1483 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0113 | 0.4146 | 0.4362 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0113 | 0.4146 | 0.4362 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0213 | 0.9504 | 1 |
Onchocerca volvulus | 0.0213 | 0.9504 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0213 | 0.9504 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | ecdysone receptor | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | nuclear hormone receptor | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0213 | 0.9504 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.1409 | 0.1483 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0048 | 0.005 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0113 | 0.4146 | 0.4362 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | RNA binding protein | 0.0061 | 0.1409 | 0.1483 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0502 | 0.0528 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0213 | 0.9504 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0101 | 0.3503 | 0.3686 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0502 | 0.0528 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0213 | 0.9504 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0213 | 0.9504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.5843 | 0.6148 |
Schistosoma mansoni | nuclear hormone receptor | 0.0101 | 0.3503 | 0.3686 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0048 | 1 |
Brugia malayi | hypothetical protein | 0.0101 | 0.3503 | 0.3686 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0101 | 0.3503 | 0.3686 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0213 | 0.9504 | 1 |
Onchocerca volvulus | 0.0101 | 0.3503 | 0.3686 | |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.5843 | 0.6148 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.5843 | 0.6148 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0213 | 0.9504 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0213 | 0.9504 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0048 | 0.005 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.1409 | 0.1483 |
Brugia malayi | hypothetical protein | 0.0113 | 0.4146 | 0.4362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1409 | 0.1483 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0113 | 0.4146 | 0.4362 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0048 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 85 uM | In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | ChEMBL. | 10098677 |
IC50 (binding) | = 85 uM | In vitro inhibition of rat brain cytosol Geranylgeranyl transferase type I | ChEMBL. | 10098677 |
IC50 (binding) | = 120 uM | In vitro inhibition of rat brain cytosol farnesyl transferase | ChEMBL. | 10098677 |
IC50 (binding) | = 120 uM | In vitro inhibition of rat brain cytosol farnesyl transferase | ChEMBL. | 10098677 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.