Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0098 | 0.0225 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.0171 | 0.0429 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0039 | 0.0137 | 0.0314 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0051 | 0.0078 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0118 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0161 | 0.037 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.0137 | 0.0314 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.0171 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0252 | 0.1426 | 0.3572 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0734 | 0.4356 | 0.4356 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0674 | 0.3991 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.022 | 0.0552 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0039 | 0.0137 | 0.0568 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0039 | 0.0137 | 0.0314 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0051 | 0.0128 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0013 | 0.0029 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0152 | 0.082 | 0.2031 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0098 | 0.0246 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.0098 | 0.0215 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0051 | 0.0097 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.0171 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0098 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.021 | 0.0481 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0051 | 0.0097 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0001 | 0.0002 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.0171 | 0.0393 |
Brugia malayi | thymidylate synthase | 0.0674 | 0.3991 | 1 |
Onchocerca volvulus | 0.0053 | 0.0218 | 0.0422 | |
Leishmania major | pyruvate kinase | 0.0033 | 0.0098 | 0.0119 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0051 | 0.0113 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 0.0863 | 0.1981 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0051 | 0.0097 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.022 | 0.0552 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0674 | 0.3991 | 0.9162 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0051 | 0.0097 |
Echinococcus granulosus | expressed conserved protein | 0.0098 | 0.0496 | 0.1138 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0098 | 0.0225 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0161 | 0.037 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0161 | 0.037 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0252 | 0.1426 | 0.1426 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0039 | 0.0137 | 0.0218 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0056 | 0.0056 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0321 | 0.1845 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.0137 | 0.0314 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0098 | 0.0246 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.0001 | 0.0002 |
Echinococcus multilocularis | expressed conserved protein | 0.0098 | 0.0496 | 0.0496 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0098 | 1 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0137 | 0.01 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0039 | 0.0137 | 0.0763 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0105 | 0.0534 | 0.0534 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.021 | 0.021 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0674 | 0.3991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0232 | 0.0582 |
Onchocerca volvulus | 0.0051 | 0.021 | 0.0402 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0218 | 0.05 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.0137 | 0.0222 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.0171 | 0.0171 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0105 | 0.0534 | 0.1338 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.0278 | 0.0638 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0098 | 0.0225 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0098 | 0.0244 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0039 | 0.0137 | 0.0137 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0098 | 0.0119 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0051 | 0.0128 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0098 | 0.0098 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 0.0863 | 0.0863 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.0038 | 0.0094 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.022 | 0.0552 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0013 | 0.0016 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0098 | 0.0119 |
Brugia malayi | Muscleblind-like protein | 0.0159 | 0.0863 | 0.2163 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0051 | 0.0097 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0118 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0171 | 0.0429 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0311 | 0.1786 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.0278 | 0.0697 |
Loa Loa (eye worm) | thymidylate synthase | 0.0674 | 0.3991 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0051 | 0.0097 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0051 | 0.0097 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0252 | 0.1426 | 0.3273 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0674 | 0.3991 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0001 | 0.0002 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0063 | 0.0278 | 0.0638 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0031 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0039 | 0.0137 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0534 | 0.1338 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0674 | 0.3991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0863 | 0.2163 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0013 | 0.0029 |
Mycobacterium ulcerans | thymidylate synthase | 0.0674 | 0.3991 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0105 | 0.0534 | 0.2839 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0137 | 0.01 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0674 | 0.3991 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0031 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0001 | 0.0001 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0098 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0051 | 0.0128 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0311 | 0.1786 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0137 | 0.01 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.021 | 0.0525 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.0278 | 0.0697 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0039 | 0.0137 | 0.0137 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0063 | 0.0278 | 0.0278 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0051 | 0.0097 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0098 | 0.0545 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0063 | 0.0278 | 0.0278 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 0.0863 | 0.0863 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0098 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0296 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0137 | 0.0222 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0171 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0863 | 0.2163 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.015 | 0.0807 | 0.0807 |
Echinococcus multilocularis | thymidylate synthase | 0.0674 | 0.3991 | 0.3991 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0152 | 0.082 | 0.1952 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0098 | 0.0246 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0098 | 0.0119 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0063 | 0.0278 | 0.0638 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0152 | 0.082 | 0.2043 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0098 | 0.0246 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0674 | 0.3991 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.036 | 0.2081 | 0.4777 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0038 | 0.0094 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Brugia malayi | hypothetical protein | 0.0321 | 0.1845 | 0.4623 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0734 | 0.4356 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0051 | 0.0128 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0674 | 0.3991 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0051 | 0.0078 |
Brugia malayi | jmjC domain containing protein | 0.0063 | 0.0278 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0218 | 0.0545 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0051 | 0.0078 |
Onchocerca volvulus | 0.0674 | 0.3991 | 1 | |
Schistosoma mansoni | patched 1 | 0.0045 | 0.0171 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.022 | 0.0552 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0039 | 0.0137 | 0.0343 |
Echinococcus multilocularis | tumor protein p63 | 0.036 | 0.2081 | 0.2081 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.0171 | 0.0429 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0098 | 0.0119 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0161 | 0.037 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0098 | 0.0246 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0321 | 0.1845 | 0.4488 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0031 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.021 | 0.0481 |
Schistosoma mansoni | jumonji domain containing protein | 0.0063 | 0.0278 | 0.0638 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0051 | 0.0113 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0001 | 0.0002 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.015 | 0.0807 | 0.1853 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0098 | 0.0098 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0321 | 0.1845 | 0.4615 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0098 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1426 | 0.3572 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0051 | 0.0128 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0105 | 0.0534 | 0.1226 |
Echinococcus granulosus | thymidylate synthase | 0.0674 | 0.3991 | 0.9162 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0137 | 0.0343 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0001 | 0.0001 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0734 | 0.4356 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0098 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0051 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0013 | 0.0031 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0311 | 0.1786 | 0.9662 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0106 | 0.0544 | 0.1249 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0063 | 0.0278 | 0.0638 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0039 | 0.0137 | 0.0137 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0098 | 0.0231 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0039 | 0.0137 | 0.0314 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0001 | 0.0001 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0674 | 0.3991 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 21 % | Antiinflammatory activity measured as the percentage inhibition of edema in carrageenan induced rat paw after peroral administration of 200 mg/kg of compound | ChEMBL. | 6609233 |
LD50 (ADMET) | > 1000 mg kg-1 | Peroral dose showing lethal effects in 50% of the rats with carrageenan -induced paw edema | ChEMBL. | 6609233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.